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Association of an impaired GH-IGF-I axis with cardiac wasting in patients with advanced cancer
BackgroundGrowth hormone (GH) resistance is characterized by high GH levels but low levels of insulin-like growth factor-I (IGF-I) and growth hormone...
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A novel role of IGFBP5 in the migration, invasion and spheroids formation induced by IGF-I and insulin in MCF-7 breast cancer cells
PurposeThe insulin-like growth factor (IGF) system includes IGF-I, IGF-II insulin and their membrane receptors. IGF system also includes a family of...
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Mouse model of Graves’ orbitopathy induced by the immunization with TSHR A and IGF-1R α subunit gene
PurposeThe study aimed to establish a mouse model of Graves’ disease (GD) with Graves’ orbitopathy (GO; GD + GO) that can represent the clinical...
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Effect of dietary gamma-aminobutyric acid on growth performance, haemato-immunological responses, antioxidant enzymes activity, ghrelin and IGF-I expression of Labeo rohita (Hamilton, 1822) fingerlings
Gamma-aminobutyric acid (GABA) is a four-carbon neurotransmitter and plays a major role in an increasing feed intake and nutrient utilization in...
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Muscle hypertrophy training does not suppress the GH/IGF axis in young adult males
PurposeThis study aimed to analyze the expression of the IGF type-1 receptor gene (IGF-1r) and IGF-I, GH, testosterone, and IGFBP-3 concentrations in...
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IGF-1’s protective effect on OSAS rats’ learning and memory
PurposePatients with obstructive sleep apnea syndrome (OSAS) frequently experience cognitive dysfunction, which may be connected to chronic...
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Association of decreased sperm motility and increased seminal plasma IGF-I, IGF-II, IGFBP-2, and PSA levels in infertile men
PurposePrevious studies have suggested the involvement of serum insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) in the...
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The effect of 8 weeks of circuit resistance training on serum levels of decorin and IGF-I in sedentary young men
PurposeDecorin is a new Myokine that effects of different exercise training on its levels is unknown. The aim of this study was to identify the...
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Importance of IGF-I levels in IVF: potential relevance for growth hormone (GH) supplementation
PurposeGrowth hormone (GH) supplementation in association with in vitro fertilization (IVF) is worldwide again increasing, even though study outcomes...
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Influence of IGF-I serum concentration on muscular regeneration capacity in patients with sarcopenia
BackgroundPrevious research has described a neuroprotective effect of IGF-I, supporting neuronal survival, axon growth and proliferation of muscle...
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Expression of Salivary and Serum IGF-1 and IGFBP-3 in Individuals With Diabetes and Oral Cancer
AimTo evaluate the expression of salivary and serum Insulin-like growth factor-1 (IGF-1) and Insulin-like growth factor binding protein-3 (IGFBP-3)...
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Paradoxical effect of dopamine-agonists on IGF-1 in patients with prolactinoma: the role of weight
PurposeAn increase of IGF-1 has been reported during therapy with dopamine agonists (DA) for prolactinomas; in such cases a correct diagnosis is...
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Very low serum IGF-1 levels are associated with vertebral fractures in adult males with beta-thalassemia major
PurposePatients with beta-thalassemia major (BTM) often develop several endocrine disorders due to chronic iron overload. They are also prone to...
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The neurobiology of insulin-like growth factor I: From neuroprotection to modulation of brain states
After decades of research in the neurobiology of IGF-I, its role as a prototypical neurotrophic factor is undisputed. However, many of its actions in...
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Mediating Effect of Insulin-Like Growth Factor-I Underlying the Link Between Vitamin D and Gestational Diabetes Mellitus
Vitamin D was well-known to be associated with gestational diabetes mellitus (GDM). Insulin-like growth factor-I (IGF-I) has been linked to vitamin D...
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Inflammation induces stunting by lowering bone mass via GH/IGF-1 inhibition in very preterm infants
BackgroundSustained systemic inflammatory response (SIR) was associated with poor postnatal growth in very preterm infants (VPI). We hypothesize that...
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Activation of NFAT by HGF and IGF-1 via ARF6 and its effector ASAP1 promotes uveal melanoma metastasis
Preventing or effectively treating metastatic uveal melanoma (UM) is critical because it occurs in about half of patients and confers a very poor...
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The relationship between morning blood pressure surge and serum IGF-1 level in acromegaly patients with hypertension
ObjectiveHigh levels of insulin-like growth factor 1 (IGF-1) in patients with acromegaly cause structural and functional changes specific to the...
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Effects of exercise on inflammatory factors and IGF system in breast cancer survivors: a meta-analysis
BackgroundAt present, there are multiple hypotheses regarding the mechanisms underlying the effect of exercise on the postoperative inflammatory...
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Effects of lifestyle intervention on IGF-1, IGFBP-3, and insulin resistance in children with obesity with or without metabolic-associated fatty liver disease
Obesity is a strong predictor for metabolic associated fatty liver disease (MAFLD), which has been associated with decreased insulin like growth...