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IFN-α/β/IFN-γ/IL-15 pathways identify GBP1-expressing tumors with an immune-responsive phenotype
Immunotherapy is widely used in cancer treatment; however, only a subset of patients responds well to it. Significant efforts have been made to...
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TIGIT reverses IFN-α-promoted Th1-like Tregs via in-sequence effects dependent on STAT4
ObjectivesThe induction direction of interferon (IFN)-α in T-cell phenotype and function varies depending on the activation state of the cell and the...
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In vitro T cell responses to PD-1 blockade are reduced by IFN-α but do not predict therapy response in melanoma patients
PD-1 blockade therapy has revolutionized melanoma treatment, but still not all patients benefit and pre-treatment identification of those patients is...
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Role of IFN-α in Rheumatoid Arthritis
Purpose of ReviewType 1 interferons (IFN-I) are of increasing interest across a wide range of autoimmune rheumatic diseases. Historically, research...
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Circulating VEGF-A, TNF-α, CCL2, IL-6, and IFN-γ as biomarkers of cancer in cancer-associated anti-TIF1-γ antibody-positive dermatomyositis
ObjectivesThe objective of the current study was to detect plasma profiles of inflammatory cytokines for determining potential biomarkers indicating...
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Curcumin assists anti-EV71 activity of IFN-α by inhibiting IFNAR1 reduction in SH-SY5Y cells
Background and aimEnterovirus 71(EV71) can cause severe hand, foot, and mouth disease (HFMD) with brain tissue involvement. Few effective anti-EV71...
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Anti-Leishmania major activity of Calotropis procera extract by increasing ROS production and upregulating TNF-α, IFN-γ and iNOS mRNA expression under in vitro conditions
BackgroundLeishmaniasis, caused by protozoan parasites of the genus Leishmania , is a neglected tropical disease with 700,000 to 1,000,000 global new...
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Restoration of HBV-specific CD8+ T-cell responses by sequential low-dose IL-2 treatment in non-responder patients after IFN-α therapy
Patients with chronic hepatitis B (CHB) undergoing interferon (IFN)-α-based therapies often exhibit a poor HBeAg serological response. Thus, there is...
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Serum biomarker panel diagnostics in pancreatic ductal adenocarcinoma: the clinical utility of soluble interleukins, IFN-γ, TNF-α and PD-1/PD-L1 in comparison to established serum tumor markers
PurposeNovel biomarkers to better predict outcome and select the best therapeutic strategy for the individual patient are necessary for pancreatic...
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Combination of levetiracetam and IFN-α increased temozolomide efficacy in MGMT-positive glioma
PurposeGlioma, especially glioblastoma (GBM), is the most aggressive malignant brain tumor and its standard therapy is often ineffective because of...
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Lupus susceptibility region containing CTLA4 rs17268364 functionally reduces CTLA4 expression by binding EWSR1 and correlates IFN-α signature
BackgroundDysregulation of T cells mediated immune responses is a hallmark in the development of systemic lupus erythematosus (SLE). Recent genome...
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Predictive value of TNF-α, IFN-γ, and IL-10 for tuberculosis among recently exposed contacts in the United States and Canada
BackgroundWe examined cytokine immune response profiles among contacts to tuberculosis patients to identify immunologic and epidemiologic correlates...
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The reduction in CD8+PD-1+ T cells in liver histological tissue is related to Pegylated IFN-α therapy outcomes in chronic hepatitis B patients
BackgroundAntiviral therapy is recommended for patients with immune-active chronic hepatitis B (CHB) to decrease the risk of liver-related...
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PET imaging shows no changes in TSPO brain density after IFN-α immune challenge in healthy human volunteers
Depression is associated with peripheral inflammation, but its link with brain microglial activity remains unclear. In seven healthy males, we used...
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Interferons are key cytokines acting on pancreatic islets in type 1 diabetes
Aims/hypothesisThe proinflammatory cytokines IFN-α, IFN-γ, IL-1β and TNF-α may contribute to innate and adaptive immune responses during insulitis in...
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The expression of interleukin-1β in patients with chronic hepatitis B treated with pegylated-interferon-alpha combined with tenofovir disoproxil fumarate and monotherapy
BackgroundAnti-hepatitis B virus (HBV) treatment uses tenofovir disoproxil fumarate (TDF) along with Pegylated-interferon-alpha (Peg-IFN-α), which is...
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Revealing the changes in signaling pathways caused by tofacitinib in patients with rheumatoid arthritis through RNA sequencing and the correlation with clinical parameters
ObjectivesThe current study is to accelerate the understanding of how tofacitinib works in patients with rheumatoid arthritis (RA) due to the lack of...
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Interferon and interferon-induced cytokines as markers of impending clinical progression in ANA+ individuals without a systemic autoimmune rheumatic disease diagnosis
BackgroundElevated levels of interferons (IFNs) are a characteristic feature of systemic autoimmune rheumatic diseases (SARDs) and may be useful in...
