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Longitudinal Assessment of Blood-Based Inflammatory, Neuromuscular, and Neurovascular Biomarker Profiles in Intensive Care Unit–Acquired Weakness: A Prospective Single-Center Cohort Study
BackgroundThe diagnosis of intensive care unit (ICU)-acquired weakness (ICUAW) and critical illness neuromyopathy (CINM) is frequently hampered in...
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Intensive Care Unit-Acquired Weakness – diagnostischer Stellenwert des neuromuskulären Ultraschalls
Intensive care unit-acquired weakness (ICUAW) is one of the most common neuromuscular complications in intensive care medicine. The clinical...
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Recovery and long term functional outcome in people with critical illness polyneuropathy and myopathy: a sco** review
BackgroundIntensive care unit acquired weakness (ICUAW), embraces an array of disorders labeled “critical illness polyneuropathy” (CIP), “critical...
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Insulin signaling in skeletal muscle during inflammation and/or immobilisation
BackgroundThe decline in the downstream signal transduction pathway of anabolic hormone, insulin, could play a key role in the muscle atrophy and...
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Quantitative muscle MRI displays clinically relevant myostructural abnormalities in long-term ICU-survivors: a case–control study
BackgroundLong-term data on ICU-survivors reveal persisting sequalae and a reduced quality-of-life even after years. Major complaints are...
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Muscular myostatin gene expression and plasma concentrations are decreased in critically ill patients
BackgroundThe objective was to investigate the role of gene expression and plasma levels of the muscular protein myostatin in intensive care...
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Ultrasound assessment of muscle mass and correlation with clinical outcomes in critically ill patients: a prospective observational study
PurposeMuscular atrophy implies structural and functional alterations related to muscular force production and movement. This condition has been...
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Neurointensivmedizin und COVID-19
This review article summarizes important findings on the interfaces between the coronavirus disease 2019 (COVID-19) pandemic and neurology with an...
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Bedside voluntary and evoked forces evaluation in intensive care unit patients: a narrative review
Around one third of intensive care unit (ICU) patients will develop severe neuromuscular alterations, known as intensive care unit-acquired weakness...
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Handgrip strength to predict extubation outcome: a prospective multicenter trial
BackgroundICU-acquired weakness (ICUAW) has been shown to be associated with prolonged duration of mechanical ventilation and extubation failure. It...
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Systematic early versus late mobilization or standard early mobilization in mechanically ventilated adult ICU patients: systematic review and meta-analysis
BackgroundThis systematic review and meta-analysis aimed to determine the effectiveness of systematic early mobilization in improving muscle strength...
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Neuromuscular Blocking Agents in the Intensive Care Unit
Purpose of ReviewThe purpose of this review is to recognize common complications associated with the use of neuromuscular blocking agents in...
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The use of muscle ultrasound to detect critical illness myopathy in patients with sepsis: an observational cohort study
BackgroundCritical illness myopathy (CIM) has negative impact on patient outcomes. We aimed to explore the diagnostic value of bedside...
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Intensive Care Unit—Acquired Weakness in Children: A Prospective Observational Study Using Simplified Serial Electrophysiological Testing (PEDCIMP Study)
BackgroundTo study the incidence and time of onset of intensive care unit—acquired weakness in a prospective cohort of children (2–12 years) by...
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The Loss of Temporal Muscle Volume is Associated with Poor Outcome in Patients with Subarachnoid Hemorrhage: An Observational Cohort Study
BackgroundIntensive care unit (ICU) acquired weakness is a major contributor to poor functional outcome of ICU patients. Quantification of temporal...
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Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study
BackgroundEarly mobilisation (EM) is an intervention that may improve the outcome of critically ill patients. There is limited data on EM in COVID-19...
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Effects of robotic-assisted early mobilization versus conventional mobilization in intensive care unit patients: prospective interventional cohort study with retrospective control group analysis
BackgroundApproximately one in three survivors of critical illness suffers from intensive-care-unit-acquired weakness, which increases mortality and...