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Standard vs. carbone dioxide adapted kidney replacement therapy in hypercapnic ARDS patients: a randomized controlled pilot trial (BigBIC)
BackgroundCurrent continuous kidney replacement therapy (CKRT) protocols ignore physiological renal compensation for hypercapnia. This study aimed to...
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Long-term outcomes in patients with COPD treated with non-invasive ventilation for acute hypercapnic respiratory failure
PurposeChronic Obstructive Lung Disease (COPD) remains a major cause of morbidity and mortality across the world. We evaluated survival over 9 years...
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High-flow nasal cannula versus non-invasive ventilation for acute hypercapnic respiratory failure in adults: a systematic review and meta-analysis of randomized trials
BackgroundNon-invasive ventilation (NIV) with bi-level positive pressure ventilation is a first-line intervention for selected patients with acute...
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Is disposable continuous positive airway pressure system effective for the management of acute hypercapnic respiratory failure?
AimThis study aimed to investigate the effectiveness of disposable continuous positive airway pressure (DCPAP) system in decreasing the partial...
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Nasal high-flow compared to non-invasive ventilation in treatment of acute acidotic hypercapnic exacerbation of chronic obstructive pulmonary disease—protocol for a randomized controlled noninferiority trial (ELVIS)
BackgroundAcute exacerbations of chronic obstructive pulmonary disease (AECOPD) have a major negative impact on health status, rates of...
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Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response
After a fortuitous observation of two cases of chemosensitivity recovery in women with congenital central hypoventilation syndrome (CCHS) who took...
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A randomised controlled trial of non-invasive ventilation compared with extracorporeal carbon dioxide removal for acute hypercapnic exacerbations of chronic obstructive pulmonary disease
BackgroundPatients presenting with acute hypercapnic respiratory failure due to exacerbations of chronic obstructive pulmonary disease (AECOPD) are...
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Prehospital reversal of profound respiratory acidosis and hypercapnic coma by non-invasive ventilation: a report of two cases
BackgroundIn chronic obstructive pulmonary disease (COPD) patients with acute respiratory failure (ARF), non-invasive ventilation (NIV) is generally...
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Salbutamol-induced lactic acidosis in status asthmaticus survivor
BackgroundSalbutamol-induced lactic acidosis is a rare presentation that could manifest in specific clinical context as acute asthmatic attack...
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Extracorporeal carbon dioxide removal for acute respiratory failure: a review of potential indications, clinical practice and open research questions
Extracorporeal carbon dioxide removal (ECCO 2 R) is a form of extracorporeal life support (ECLS) largely aimed at removing carbon dioxide in patients...
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Evaluation of the safety and efficacy of extracorporeal carbon dioxide removal in the critically ill using the PrismaLung+ device
BackgroundSeveral extracorporeal carbon dioxide removal (ECCO 2 R) devices are currently in use with variable efficacy and safety profiles....
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A retrospective study of the role of hypercapnia in patients with acromegaly
BackgroundAcromegaly is a multisystemic disease characterized by an excessive release of growth hormone (GH) and insulin-like growth factor-1....
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Extracorporeal carbon dioxide removal for treatment of exacerbated chronic obstructive pulmonary disease (ORION): study protocol for a randomised controlled trial
BackgroundHypercapnic exacerbations are severe complications of chronic obstructive pulmonary disease (COPD), characterized by negative impact on...
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A comparison of two weaning strategies for non-invasive ventilation in chronic obstructive pulmonary disease patients with acute respiratory failure
IntroductionNon-Invasive Ventilation (NIV) is a crucial therapy for managing acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD) with...
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Current Evidence Surrounding the Use of Sodium Bicarbonate in the Critically Ill Patient
Purpose of ReviewPatients requiring admission to the intensive care unit frequently develop severe metabolic acidosis. Severe and prolonged acidosis...
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The use of extracorporeal CO2 removal in acute respiratory failure
BackgroundChronic obstructive pulmonary disease (COPD) exacerbation and protective mechanical ventilation of acute respiratory distress syndrome...
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Successful management of temporary veno-venous extracorporeal membrane oxygenation for a pediatric lung transplant recipient with bronchiolitis obliterans syndrome awaiting lung re-transplantation: a case report
BackgroundThe use of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation is an uncommon strategy in Japan owing to the...
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Dyspnea in young subjects with congenital central hypoventilation syndrome
BackgroundIt has been stated that patients with congenital central hypoventilation syndrome (CCHS) do not perceive dyspnea, which could be related to...
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Effects of extracorporeal CO2 removal on gas exchange and ventilator settings: a systematic review and meta-analysis
PurposeA systematic review and meta-analysis to evaluate the impact of extracorporeal carbon dioxide removal (ECCO 2 R) on gas exchange and...
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Complications of metabolic acidosis and alkalinizing therapy in chronic kidney disease patients: a clinician-directed organ-specific primer
Chronic kidney disease is prevalent, affecting more than one in ten adults. In this population, metabolic acidosis is considered a key underlying...
