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Similarities and Differences Between Pragmatic Trials and Hybrid Effectiveness-Implementation Trials
Pragmatism in clinical trials is focused on increasing the generalizability of research findings for routine clinical care settings. Hybridism in...
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The unrecognized role of fidelity in effectiveness-implementation hybrid trials: simulation study and guidance for implementation researchers
BackgroundEffectiveness-implementation hybrid designs are a relatively new approach to evaluate efficacious interventions in real-world settings...
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Using simulation modeling to inform intervention and implementation selection in a rapid stakeholder-engaged hybrid effectiveness-implementation randomized trial
BackgroundImplementation research generally assumes established evidence-based practices and prior piloting of implementation strategies, which may...
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MyBack - effectiveness and implementation of a behavior change informed exercise programme to prevent low back pain recurrences: a hybrid effectiveness-implementation randomized controlled study protocol
BackgroundLow back pain (LBP) is a common health condition and the leading cause of years lived with disability worldwide. Most LBP episodes have a...
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Implementation of an internet-based stress management program in micro- and small-sized enterprises: a study protocol for a pre-post feasibility study of the effectiveness-implementation hybrid type 2 trial
BackgroundAlthough internet-based stress management programs are proven effective in improving mental health among workers, micro- and small-sized...
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Implementation intensification to disseminate a skills-based caregiver training program: protocol for a type III effectiveness-implementation hybrid trial
BackgroundFamily caregiver training decreases caregiver psychological burden and improves caregiver depressive symptoms and health-related quality of...
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Advancing sustainable implementation of an evidence-based mental health intervention in Sierra Leone’s schools: protocol for a hybrid type 3 implementation-effectiveness trial
BackgroundMental health disorders among youth contribute substantially to the global burden of disease, which is exacerbated in low- and...
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Accelerating Solutions for the Overdose Crisis: an Effectiveness-Implementation Hybrid Protocol for the HEAL Prevention Cooperative
Given increasing opioid overdose mortality rates in the USA over the past 20 years, accelerating the implementation of prevention interventions found...
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Implementation of coordinated spontaneous awakening and breathing trials using telehealth-enabled, real-time audit and feedback for clinician adherence (TEACH): a type II hybrid effectiveness-implementation cluster-randomized trial
BackgroundIntensive care unit (ICU) patients on mechanical ventilation often require sedation and analgesia to improve comfort and decrease pain....
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Evaluation of strategies to support implementation of a hospital walking program: protocol for a type III effectiveness-implementation hybrid trial
BackgroundSTRIDE is a supervised walking program designed to address the negative consequences of immobility during hospitalization for older adults....
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Alarm with care—a de-implementation strategy to reduce fall prevention alarm use in US hospitals: a study protocol for a hybrid 2 effectiveness-implementation trial
BackgroundFall prevention alarms are commonly used among US hospitals as a fall prevention strategy despite limited evidence of effectiveness....
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Effectiveness and feasibility of a motivational interviewing intake (MII) intervention for increasing client engagement in outpatient addiction treatment: an effectiveness-implementation hybrid design protocol
BackgroundClient discontinuation from outpatient addiction treatment programs is common, and the initial intake is the service delivery point with...
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An Integrated Care Pathway for depression in adolescents: protocol for a Type 1 Hybrid Effectiveness-implementation, Non-randomized, Cluster Controlled Trial
IntroductionOur group developed an Integrated Care Pathway to facilitate the delivery of evidence-based care for adolescents experiencing depression...
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Family cascade screening for equitable identification of familial hypercholesterolemia: study protocol for a hybrid effectiveness-implementation type III randomized controlled trial
BackgroundFamilial hypercholesterolemia (FH) is a heritable disorder affecting 1.3 million individuals in the USA. Eighty percent of people with FH...
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A health-social service partnership programme for improving the health self-management of community-dwelling older adults: a hybrid effectiveness-implementation pilot study protocol
BackgroundThe ageing population requires seamless, integrated health and social care services in the community to promote the health of older adults....
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Cardiovascular Rehabilitation for transient ischaemic Attack and Mild Stroke: the CRAMS effectiveness-implementation hybrid study protocol
BackgroundInternationally, stroke and cardiac rehabilitation clinicians agree that current cardiac rehabilitation models are a suitable secondary...
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Multiphasic exercise prehabilitation for patients undergoing surgery for head and neck cancer: a hybrid effectiveness-implementation study protocol
Head and neck cancer (HNC) treatment often consists of major surgery followed by adjuvant therapy, which can result in treatment-related side...
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Low-Intensity mental health Support via a Telehealth Enabled Network for adults with diabetes (LISTEN): protocol for a hybrid type 1 effectiveness implementation trial
BackgroundMental health problems are common among people with diabetes. However, evidence-based strategies for the prevention and early intervention...
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Personalising genetic counselling (POETIC) trial: Protocol for a hybrid type II effectiveness-implementation randomised clinical trial of a patient screening tool to improve patient empowerment after cancer genetic counselling
BackgroundGenetic counselling aims to identify, and address, patient needs while facilitating informed decision-making about genetic testing and...
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ENABLE-SG (Educate, Nurture, Advise, Before Life Ends for Singapore) as a proactive palliative care model: protocol for a hybrid type 1 effectiveness-implementation randomized wait-list controlled trial
BackgroundSpecialist palliative care is often provided late in the patient’s disease trajectory in response to uncontrolled symptoms. Shifting from...
