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Renal pelvic plasmacytoid subtype urothelial carcinoma accompanied with solitary mammary metastasis
A 72-year-old female was referred to our institution for further evaluation of right renal tumor detected during work-up for macroscopic hematuria in...
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Analysis of serum peptidome profiles of non-metastatic and metastatic feline mammary carcinoma using liquid chromatography-tandem mass spectrometry
BackgroundFeline mammary carcinoma (FMC) is a common aggressive and highly metastatic cancer affecting female cats. Early detection is essential for...
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Upregulation of SLUG expression in canine mammary gland tumors and its prognostic significance
BackgroundSLUG (also known as snai2), which is a transcription factor in epithelial–mesenchymal transition (EMT), plays an important role in...
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FGFR2 Controls Growth, Adhesion and Migration of Nontumorigenic Human Mammary Epithelial Cells by Regulation of Integrin β1 Degradation
The role of fibroblast growth factor receptor 2 (FGFR2), an important mediator of stromal paracrine and autocrine signals, in mammary gland...
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Comparative analysis of the molecular subtype landscape in canine and human mammary gland tumors
Breast cancers in humans belong to one of several intrinsic molecular subtypes each with different tumor biology and different clinical impact....
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Hedgehog blockade remodels the gut microbiota and the intestinal effector CD8+ T cells in a mouse model of mammary carcinoma
Given the gut microbiome’s rise as a potential frontier in cancer pathogenesis and therapy, leveraging microbial analyses in the study of breast...
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Deciphering Stromal Changes between Metastatic and Non-metastatic Canine Mammary Carcinomas
Cancer-associated stroma (CAS) is widely recognized to influence development and progression of epithelial tumours including breast cancer. Canine...
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Spatial Engineering of Mammary Epithelial Cell Cultures with 3D Bioprinting Reveals Growth Control by Branch Point Proximity
The three-dimensional (3D) structure of the ductal epithelium and the surrounding extracellular matrix (ECM) are integral aspects of the breast...
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Treatment of HER2-positive cutaneous apocrine carcinoma of the axilla
Cutaneous apocrine carcinoma (CAC) is an extremely rare skin appendage malignant tumor that develops in the apocrine sweat glands, and no...
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Establishment and characterization of a HER2-enriched canine mammary cancerous myoepithelial cell line
BackgroundCanine mammary tumors (CMTs) have a poor prognosis, along with tumor recurrence and metastasis. Cell lines are vital in vitro models for...
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Usability of serum hedgehog signalling proteins as biomarkers in canine mammary carcinomas
BackgroundThe hedgehog signalling pathway has been implicated in tumourigenesis and progression of many tumour types. This pathway has recently...
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Establishment of canine mammary gland tumor cell lines harboring PI3K/Akt activation as a therapeutic target
Canine mammary gland tumors (MGT) have a poor prognosis in intact female canines, posing a clinical challenge. This study aimed to establish novel...
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Thirteenth Annual ENBDC Workshop: Methods in Mammary Gland Biology and Breast Cancer
The thirteenth annual workshop of the European Network for Breast Development and Cancer (ENBDC) Laboratories Annual Workshop took place on the 28–30...
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Toward Characterizing Lymphatic Vasculature in the Mammary Gland During Normal Development and Tumor-Associated Remodeling
Lymphatic vasculature has been shown to promote metastatic spread of breast cancer. Lymphatic vasculature, which is made up of larger collecting...
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Epidemiology of canine mammary tumours on the Canary Archipelago in Spain
BackgroundMammary gland tumours are the most frequently diagnosed tumours in the female dogs but just a few studies have analysed their epidemiology....
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Induced mammary cancer in rat models: pathogenesis, genetics, and relevance to female breast cancer
Mammary cancer, or breast cancer in women, is a polygenic disease with a complex etiopathogenesis. While much remains elusive regarding its origin,...
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SFRP1 Expression is Inversely Associated With Metastasis Formation in Canine Mammary Tumours
BackgroundCanine mammary tumours (CMTs) are the most frequent tumours in intact female dogs and show strong similarities with human breast cancer. In...
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ERBB Receptors and Their Ligands in the Develo** Mammary Glands of Different Species: Fifteen Characters in Search of an Author
The ERBB tyrosine kinase receptors and their ligands belong to a complex family that has diverse biological effects and expression profiles in the...
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Associations Between Dog Breed and Clinical Features of Mammary Epithelial Neoplasia in Bitches: an Epidemiological Study of Submissions to a Single Diagnostic Pathology Centre Between 2008–2021
Mammary cancer is one of the most common neoplasms of dogs, primarily bitches. While studies have been carried out identifying differing risk of...
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Characterization of neoplastic cells outlining the cystic space of invasive micropapillary carcinoma of the canine mammary gland
BackgroundInvasive micropapillary carcinoma (IMPC) is a rare malignant breast tumor and a variant form of invasive ductal carcinoma that is an...