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Emerging roles of noncoding RNAs in human cancers
Studies have found that RNA encoding proteins only account for a small part of the total number, most RNA is non-coding RNA, and non-coding RNA may...
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Carcinogenic roles of MAFG-AS1 in human cancers
The MAF bZIP transcription factor G-antisense RNA 1 (MAFG-AS1) is located on chromosome 17. MAFG-AS1 was upregulated in 15 human cancers. MAFG-AS1...
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Pan-cancer analysis combined with experiments predicts NNMT as a therapeutic target for human cancers
The identification of effective therapeutic targets plays a pivotal role in advancing cancer treatment outcomes. We employed a comprehensive...
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Circular RNAs-mediated angiogenesis in human cancers
Circular RNAs (circRNAs) as small non-coding RNAs with cell, tissue, or organ-specific expression accomplish a broad array of functions in...
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New perspectives for targeting therapy in ALK-positive human cancers
Anaplastic lymphoma kinase (ALK) is a member of the insulin receptor protein-tyrosine kinase superfamily and was first discovered in anaplastic...
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Association of Human Papillomavirus Infection with Tonsillar Cancers: A Systematic Review
Vaccinations have shown a decrease in human papillomavirus (HPV) infection-related cervical cancer in women, but there has been a sharp rise in the...
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Human Papilloma Virus Related Cancers in People Living with HIV
Purpose of ReviewThe burden of HPV co-infection in people living with HIV is high leading to increase incidence of HPV-related malignancies....
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Human papillomavirus infection and non-oropharyngeal head and neck cancers: an umbrella review of meta-analysis
ObjectiveThe causative and prognostic roles of human papillomavirus (HPV) in non-oropharyngeal squamous cell carcinoma of the head and neck are...
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Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers
BackgroundDysregulation of enhancer transcription occurs in multiple cancers. Enhancer RNAs (eRNAs) are transcribed products from enhancers that play...
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Prognostic and clinicopathologic significance of circZFR in multiple human cancers
BackgroundAbnormally expressed in diverse cancers, circZFR has been correlated with clinical outcomes of cancer patients. Aim of this meta-analysis...
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A pan-cancer analysis for the oncogenic role of cyclin-dependent kinase inhibitor 1B in human cancers
BackgroundHuman health and life are threatened by cancer with high morbidity and mortality worldwide. In many experiments, CDKN1B level is associated...
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eccDNAdb: a database of extrachromosomal circular DNA profiles in human cancers
E xtra c hromosomal c ircular DNA ( eccDNA ) elements are circular DNA molecules that are derived from but are independent of chromosomal DNA. EccDNA is...
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CYFIP2 serves as a prognostic biomarker and correlates with tumor immune microenvironment in human cancers
BackgroundThe mechanisms whereby CYFIP2 acts in tumor development and drives immune infiltration have been poorly explored. Thus, this study aimed to...
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A combined analysis of multi-omics data reveals the prognostic values and immunotherapy response of LAG3 in human cancers
Lymphocyte-activation gene 3 (LAG3) is a highly anticipated immune checkpoint in the context of cancer, exerting regulatory control over immune cell...
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Epidemiology of HPV-associated cancers past, present and future: towards prevention and elimination
Cervical cancer is the first cancer deemed amenable to elimination through prevention, and thus lessons from the epidemiology and prevention of this...
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The role of RNA modification in urological cancers: mechanisms and clinical potential
RNA modification is a post-transcriptional level of regulation that is widely distributed in all types of RNAs, including mRNA, tRNA, rRNA, miRNA,...
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ARID1A in Gynecologic Precancers and Cancers
The highest frequency of genetic alterations in the tumor suppressor ARID1A occurs in malignancies of the female reproductive tract. The prevalence...
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Radiotherapy resistance: identifying universal biomarkers for various human cancers
Radiotherapy (RT) is considered as a standard in the treatment of most solid cancers, including glioblastoma, lung, breast, rectal, prostate,...
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Targeting DNA Damage Response Deficiency in Thoracic Cancers
Thoracic cancers comprise non-small cell lung cancers (NSCLCs), small cell lung cancers (SCLCs) and malignant pleural mesotheliomas (MPM)....
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Antibody-Drug Conjugates in Gynecologic Cancers
Antibody-drug conjugates (ADCs) are a novel class of targeted cancer therapies with the ability to selectively deliver a cytotoxic drug to a tumor...