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Human T-cell lymphotropic virus type 1 (HTLV-1) proposed vaccines: a systematic review of preclinical and clinical studies
BackgroundNumerous vaccination research experiments have been conducted on non-primate hosts to prevent or control HTLV-1 infection. Therefore,...
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Therapeutic approaches for HTLV-1-associated adult T-cell leukemia/lymphoma: a comprehensive review
Adult T-cell leukemia/lymphoma (ATLL), an infrequent malignancy resultant from human T-cell lymphotropic virus type I (HTLV-1), exhibits a spectrum...
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Multicenter, randomized, double-blind, placebo-controlled phase 3 study of mogamulizumab with open-label extension study in a minimum number of patients with human T-cell leukemia virus type-1-associated myelopathy
Human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic neurodegenerative disease. This...
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Evaluation of human T-cell leukemia virus in vitro diagnostics using plasma specimens collected in Japan
BackgroundIn vitro diagnostics (IVDs) for primary detection test/screening of human T-cell leukemia virus (HTLV) have recently been updated to...
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Outcome of Stem Cell Transplantation in HTLV-1-Associated North American Adult T-Cell Leukemia/Lymphoma
Adult T-cell leukemia/lymphoma (ATLL) remains challenging to treat and has dismal outcome. Allogeneic stem-cell transplantation (allo-SCT) has...
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Radiographic aspects in individuals infected by human T-lymphotropic virus type 1 (HTLV-1) with joint pain
BackgroundJoint pain in the absence or with little synovitis is observed in a large percentage of HTLV-1 infected subjects. As the virus infect...
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Decoding dysregulated angiogenesis in HTLV-1 asymptomatic carriers compared to healthy individuals
Human T-cell lymphotropic virus type 1 (HTLV-1) is the first identified human retrovirus responsible for two significant diseases: HTLV-1-associated...
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Heat shock factor 1 is a promising therapeutic target against adult T-cell leukemia
Patients with adult T-cell leukemia (ATL), which is caused by human T-cell leukemia virus type 1 (HTLV-1), show poor prognosis because of drug...
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Imbalanced IL10/TGF-β production by regulatory T-lymphocytes in patients with HTLV-1-associated myelopathy/ tropical spastic paraparesis
BackgroundHuman T-cell lymphotropic virus type 1 (HTLV-1), also denominated Human T-cell leukemia virus-1, induces immune activation and secretion of...
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Treatment of Adult T-Cell Leukemia/Lymphoma: Established Paradigms and Emerging Directions
Adult T-cell leukemia/lymphoma (ATL) is a rare, aggressive subtype of peripheral T-cell lymphoma develo** after many years of chronic, asymptomatic...
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Possible mechanisms underlying the association between human T-cell leukemia virus type 1 (HTLV-1) and hypertension in elderly Japanese population
BackgroundHuman T-cell leukemia virus type 1 (HTLV-1) activates inflammatory cascades by activating the NF-κB pathway. The minor allele of single...
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Viral, genetic, and immune factors in the oncogenesis of adult T-cell leukemia/lymphoma
Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature CD4 + T cells induced by human T-cell leukemia virus type I (HTLV-1). HTLV-1 maintains...
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A case of acute kidney injury due to native kidney BK polyomavirus-associated nephropathy in a human T-lymphotropic virus type 1 carrier
BackgroundBK polyomavirus-associated nephropathy (BKPyVAN) has become a major cause of kidney dysfunction and graft loss in kidney transplant...
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Prevalence of human T-cell lymphotropic virus-1/2 in Canada over 33 years: A unique contribution of blood donors to public health surveillance
ObjectivesEstimate HTLV-1/2 (human T-cell lymphotropic viruses) prevalence in Canadian blood donors and the association of demographic variables with...
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Impaired humoral immunity following COVID-19 vaccination in HTLV-1 carriers
BackgroundWhether human T-lymphotropic virus type 1 (HTLV-1) carriers can develop sufficient humoral immunity after coronavirus disease 2019...
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Adult T-cell Leukemia/Lymphoma (ATL) in the Nasal and Paranasal Cavity: Four Cases Report
Adult T-cell leukemia/lymphoma (ATL) is a form of leukemia caused by the human T-cell leukemia virus type I (HTLV-1). Otolaryngologists often...
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CD30 stimulation induces multinucleation and chromosomal instability in HTLV-1-infected cell lines
A recent report indicated involvement of CD30 in progression of human leukemia virus type 1 (HTLV-1) infection, but the exact roles of CD30 in this...
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Attack of the clones: a T-cell population resembling adult T-cell leukemia/lymphoma, and large granular lymphocytosis, in an HTLV-2-infected patient
The HTLV-1 and HTLV-2 viruses, though closely genetically related, have divergent clinical impact: HTLV-1 has been causally linked with adult T-cell...
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Exportin-1 is critical for cell proliferation and survival in adult T cell leukemia
Since treatment options for adult T cell leukemia (ATL) associated with human T cell leukemia virus type 1 (HTLV-1) fail to obtain long-term...
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Allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia/lymphoma with HTLV-1-associated myelopathy
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) can be curative for adult T-cell leukemia/lymphoma (ATL), but comorbidities increase...
