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Distinct host-response signatures in circulatory shock: a narrative review
Circulatory shock is defined syndromically as hypotension associated with tissue hypoperfusion and often subcategorized according to hemodynamic...
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Targeting the host response in sepsis: current approaches and future evidence
Sepsis, a dysregulated host response to infection characterized by organ failure, is one of the leading causes of death worldwide. Disbalances of the...
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The individual response to antibiotics and diet — insights into gut microbial resilience and host metabolism
Antibiotic use disrupts microbial composition and activity in humans, but whether this disruption in turn affects host metabolic health is unclear....
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Differentiating infection, colonisation, and sterile inflammation in critical illness: the emerging role of host-response profiling
Infection results when a pathogen produces host tissue damage and elicits an immune response. Critically ill patients experience immune activation...
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Glucocorticoid use in acute respiratory failure from pulmonary causes and association with early changes in the systemic host immune response
BackgroundGlucocorticoids are commonly used in patients with or at-risk for acute respiratory distress syndrome (ARDS), but optimal use remains...
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Plasma protein biomarkers reflective of the host response in patients develo** Intensive Care Unit-acquired pneumonia
BackgroundImmune suppression has been implicated in the occurrence of pneumonia in critically ill patients. We tested the hypothesis that Intensive...
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Monocyte state 1 (MS1) cells in critically ill patients with sepsis or non-infectious conditions: association with disease course and host response
BackgroundSepsis is a life-threatening condition arising from an aberrant host response to infection. Recent single-cell RNA sequencing...
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Comparison of mechanical properties and host tissue response to OviTex™ and Strattice™ surgical meshes
PurposeThis study compared the in vitro/benchtop and in vivo mechanical properties and host biologic response to ovine rumen-derived/polymer mesh...
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Association between age and the host response in critically ill patients with sepsis
BackgroundThe association of ageing with increased sepsis mortality is well established. Nonetheless, current investigations on the influence of age...
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Metataxonomic analysis and host proteome response in dairy cows with high and low somatic cell count: a quarter level investigation
Host response to invasive microbes in the bovine udder has an important role on the animal health and is essential to the dairy industry to ensure...
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Serum metabolomic signatures of fatty acid oxidation defects differentiate host-response subphenotypes of acute respiratory distress syndrome
BackgroundFatty acid oxidation (FAO) defects have been implicated in experimental models of acute lung injury and associated with poor outcomes in...
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Mycoplasma gallisepticum escapes the host immune response via gga-miR-365-3p/SOCS5/STATs axis
A disruption in the expression of gga-miR-365-3p was confirmed in the Mycoplasma gallisepticum (MG)-infected Chicken primary alveolar type II...
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A 29-mRNA host-response classifier identifies bacterial infections following liver transplantation – a pilot study
PurposeInfections are common complications in patients following liver transplantation (LTX). The early diagnosis and prognosis of these infections...
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A novel approach to visualize clinical benefit of therapies for chronic graft versus host disease (cGvHD): the probability of being in response (PBR) applied to the REACH3 study
Overall response rate (ORR) is commonly used as key endpoint to assess treatment efficacy of chronic graft versus host disease (cGvHD), either as ORR...
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Detection of group A streptococcus in children with confirmed viral pharyngitis and antiviral host response
Our aim was to study the detection of group A streptococcus (GAS) with different diagnostic methods in paediatric pharyngitis patients with and...
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Correlation of host factor with virological response to direct-acting antiviral treatment in hepatitis C patients
BackgroundHepatitis C virus (HCV) infection is the global epidemic of this century, affecting almost 100 million people, and it is now the leading...
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Interrogating the sepsis host immune response using cytomics
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be...
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Host immune response to infection with porcine circoviruses
Porcine circovirus type 2 (PCV2), which serves as a major causative agent of PCV2-associated diseases and causes severe loss to the pig industry...
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Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections
BackgroundNecrotising soft tissue infections (NSTIs) are rapidly progressing bacterial infections usually caused by either several pathogens in...
