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Diagnosing and treating anterior pituitary hormone deficiency in pediatric patients
Hypopituitarism, or the failure to secrete hormones produced by the anterior pituitary (adenohypophysis) and/or to release hormones from the...
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Epidemiology of growth hormone deficiency in children and adolescents: a systematic review
ObjectiveGrowth hormone deficiency (GHD) is the most common pituitary hormone deficiency and is one of the main causes of short stature in children...
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Clinico-radiological correlation of pituitary stalk interruption syndrome in children with growth hormone deficiency
PurposeTo analyze the clinical, hormonal, and radiological characteristics of Pituitary stalk interruption syndrome (PSIS) in children with growth...
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Screening of GHSR, GHRHR, GH1 genes in isolated growth hormone deficiency disease in Egyptian patients
BackgroundIsolated growth hormone deficiency (IGHD) is a hereditary disorder that causes significant short stature. GHD has a reported incidence of...
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Psychometric Validation of the Growth Hormone Deficiency–Child Treatment Burden Measure (GHD-CTB) and the Growth Hormone Deficiency–Parent Treatment Burden Measure (GHD-PTB)
PurposeThe aim was to evaluate the measurement properties of the Growth Hormone Deficiency–Child Treatment Burden Measure–Child (GHD-CTB–Child), a...
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Idiopathic isolated adrenocorticotropic hormone deficiency: a systematic review of a heterogeneous and underreported disease
Isolated adrenocorticotropic hormone deficiency (IAD) is considered to be a rare disease. Due to the nonspecific clinical presentation, precise data...
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SEC31A may be associated with pituitary hormone deficiency and gonadal dysgenesis
PurposeDisorders/differences of sex development (DSD) result from variants in many different human genes but, frequently, have no detectable...
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Brain white matter alterations in young adult male patients with childhood-onset growth hormone deficiency: a diffusion tensor imaging study
PurposeThis study aimed to detect white matter changes and different effects of thyroid hormone on the white matter integrity in young adult male...
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Corticotropin-releasing hormone deficiency results in impaired analgesic response during CFA-induced inflammation
PurposeCorticotropin-releasing hormone (CRH) plays an important role in relief of pain by releasing analgesia-associated molecules in several...
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Antidiuretic hormone deficiency secondary to inactive hydrocephalus: a case report
BackgroundDiabetes insipidus is a syndrome characterized by polyuria, which is almost always associated with polydipsia. The most frequent cause is...
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Efficacy, safety, and patient satisfaction of norditropin and sogroya in patients with growth hormone deficiency: a systematic review and meta-analysis of randomized controlled trials
IntroductionGrowth hormone deficiency occurs when the pituitary gland does not produce enough growth hormone. Norditropin®, a recombinant human...
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Combined pituitary hormone deficiency harboring CHD7 gene missense mutation without CHARGE syndrome: a case report
BackgroundHeterozygous loss-of-function mutations in the chromodomain helicase DNA-binding protein 7 ( CHD7 ) gene cause CHARGE syndrome characterized...
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Isolated adrenocorticotropic hormone deficiency following immune checkpoint inhibitors treatment often occurs in polyglandular endocrinopathies
BackgroundWith the increasing application of immune checkpoint inhibitors (ICI) in cancer therapy, the occurrence of isolated adrenocorticotropic...
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The economic burden of pediatric growth hormone deficiency in Italy: a cost of illness study
PurposeGrowth hormone deficiency (GHD) is a rare condition with a worldwide prevalence of 1 patient in 4000 to 10,000 live births, placing a...
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Bone mineral density in adults growth hormone deficiency with different ages of onset: a real-world retrospective study
PurposeBone mineral density (BMD) impairment is one of the critical factors for long-term quality of life in adults growth hormone deficiency (AGHD)....
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Acquired thyroid-stimulating hormone, luteinizing hormone, and follicle-stimulating hormone deficiencies with circulating anti-glycoprotein hormones alpha chain-positive cell antibodies
BackgroundA patient with systemic lupus erythematosus (SLE) suffered from acquired thyroid-stimulating hormone (TSH), luteinizing hormone (LH), and...
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The Growth Hormone Deficiency (GHD) Reversal Trial: effect on final height of discontinuation versus continuation of growth hormone treatment in pubertal children with isolated GHD—a non-inferiority Randomised Controlled Trial (RCT)
BackgroundGrowth hormone deficiency (GHD) is the commonest endocrine cause of short stature and may occur in isolation (I-GHD) or combined with...
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Aromatase inhibitors: a useful additional therapeutic option for slowing down advanced bone age in boys with growth hormone deficiency
IntroductionAromatase inhibitors (AIs) have been used to slow down estrogen-dependent skeletal maturation in pubertal boys with short stature. In the...
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Isolated adrenocorticotropic hormone deficiency and sialadenitis associated with nivolumab: a case report
BackgroundImmune checkpoint inhibition with anti-PD(L)1 and anti-CTLA4 antibodies has significantly changed cancer treatment during the last...
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Isolated adrenocorticotropic hormone deficiency associated with sintilimab therapy in a patient with advanced lung adenocarcinoma: a case report and literature review
BackgroundSeveral immune checkpoint inhibitors have been implemented for cancer treatment which have shown some degree of antitumor effcacy, while...
