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Adult Hirschsprung’s disease presenting as chronic constipation: a case report
BackgroundHirschsprung’s disease is a congenital disorder identified by the absence of ganglion cells at the Meissner’s plexus of the submucosa and...
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Laparoscopic-assisted versus complete transanal pull-through using Swenson technique in treatment of Hirschsprung’s disease
BackgroundThe aim of this study is to compare outcomes for neonates and infants with Hirschsprung’s disease undergoing a laparoscopically assisted...
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mRNA sequencing provides new insights into the pathogenesis of Hirschsprung’s disease in mice
PurposeThe aim of this study is to use RNA sequencing and RT-qPCR to identify the main susceptibility genes linked to the occurrence and development...
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Comprehensive characterization of the genetic landscape of familial Hirschsprung’s disease
BackgroundHirschsprung’s disease (HSCR) is one of the most common congenital digestive tract malformations and can cause stubborn constipation or...
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High incidence of EDNRB gene mutation in seven southern Chinese familial cases with Hirschsprung’s disease
PurposeHirschsprung’s disease (HSCR) is the leading cause of neonatal functional intestinal obstruction, which has been identified in many familial...
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A case of Hirschsprung’s disease with segmental dilatation of the colon
BackgroundSegmental dilatation of the colon (SDC) is a rare disease that is characterized by an abrupt segment of dilated colon between regions of...
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Hirschsprung’s disease: m6A methylase VIRMA suppresses cell migration and proliferation by regulating GSK3β
BackgroundN6-methyladenosine (m6A) is the most abundant mRNA modification in mammals, participating in various biological processes. VIRMA is a key...
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Systematic appraisal of the guidelines for the diagnosis and treatment of Hirschsprung’s disease
BackgroundSome guidelines for management of Hirschsprung’s disease (HSCR, HD) have been developed, but their quality is vague. This study will...
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Experiences of youth growing up with anorectal malformation or Hirschsprung’s disease: a multicenter qualitative in-depth interview study
PurposePatients with anorectal malformation (ARM) and Hirschsprung’s disease (HD) live with long-term impact of these diseases even into adulthood....
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Genetics of Hirschsprung’s disease
Hirschsprung’s disease (HSCR) is a classical model of enteric neuropathy, occurring in approximately 2–2.8 in 10,000 newborns. It is the commonest...
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Impact of Colorectal Nurse Specialist supervised parental administration of rectal washouts on Hirschsprung’s disease outcomes: a retrospective review
PurposeTo highlight the utility of Colorectal Nurse Specialist (CNS) supervised parental administration of rectal washouts in the management of...
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Histopathological dimensions differ between aganglionic and ganglionic bowel wall in children with Hirschsprung’s disease
BackgroundIn the validation of new imaging technology for children with Hirschsprung’s disease (HSCR), basic anatomical parameters of the bowel wall...
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Diet and bowel function in children with Hirschsprung’s disease: development and content validation of a patient-reported questionnaire
BackgroundAlthough dietary adjustments are recommended frequently for bowel symptoms, evidence of diet’s impact on bowel function is lacking. The aim...
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A rare case of pyosalpinx in adolescent girl with Hirschsprung’s disease who underwent transvaginal ultrasound-guided drainage
BackgroundHydrosalpinx and pyosalpinx are rare gynecologic problems during adolescence, especially in girls without a history of sexual activity....
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Comparation of robotic-assisted surgery and laparoscopic‑assisted surgery in children with Hirschsprung’s disease: a single-centered retrospective study
BackgroundThere are few studies comparing robotic-assisted surgery (RAS) and laparoscopic-assisted surgery (LAS) in Hirschsprung’s disease (HSCR)....
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Physical self-concept and ability to swim in patients born with anorectal malformation and Hirschsprung’s disease: a case control study
BackgroundChildren with anorectal malformation (ARM) and Hirschsprung’s Disease (HD) live with permanent urinary and bowel symptoms, possibly...
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Enhancing diagnosis of Hirschsprung’s disease using deep learning from histological sections of post pull-through specimens: preliminary results
PurposeAccurate histological diagnosis in Hirschsprung disease (HD) is challenging, due to its complexity and potential for errors. In this study, we...
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Transanal endorectal or transabdominal pull-through for Hirschsprung’s disease; which is better? A systematic review and meta-analysis
AimHesitations concerning the long-term results of transanal endorectal pull-through (TEPT) due to prolonged anal stretching and resultant stricture...
