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Cardiac contractility modulation in patients with heart failure — A review of the literature
Experimental in vivo and in vitro studies showed that electric currents applied during the absolute refractory period can modulate cardiac...
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Cardiac contractility modulation: an effective treatment strategy for heart failure beyond reduced left ventricular ejection fraction?
Heart failure (HF) with preserved ejection fraction (HFpEF) causes a progressive limitation of functional capacity, poor quality of life (QoL) and...
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Effect of empagliflozin on left ventricular contractility and peak oxygen uptake in subjects with type 2 diabetes without heart disease: results of the EMPA-HEART trial
BackgroundThe mechanism through which sodium-glucose cotransporter 2 inhibitors (SGLT2i) prevent the incidence of heart failure and/or affect cardiac...
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Myocardial contractility characteristics of hypertrophic cardiomyopathy patients with and without sarcomere mutation
Hypertrophic cardiomyopathy (HCM) patients with sarcomere mutations have an increased risk of heart failure and left ventricular...
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Physical exercise is essential for increasing ventricular contractility in hypertensive rats treated with losartan
The treatment of hypertensive patients with losartan is very common. Despite the reduction in blood pressure, its effects on cardiac contractility...
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Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility
The ketone body 3-hydroxybutyrate (3-OHB) increases cardiac output and myocardial perfusion without affecting blood pressure in humans, but the...
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HF Etiology and cardiac contractility modulation therapy
ObjectivesOur study aimed to assess the safety and efficacy of cardiac contractility modulation (CCM) therapy in patients with heart failure with...
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Mechanisms maintaining right ventricular contractility-to-pulmonary arterial elastance ratio in VA ECMO: a retrospective animal data analysis of RV–PA coupling
BackgroundTo optimize right ventricular–pulmonary coupling during veno-arterial (VA) ECMO weaning, inotropes, vasopressors and/or vasodilators are...
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Right ventricular contractility affects the clinical efficacy of add-on tolvaptan following hospitalization for heart failure in patients with significant tricuspid regurgitation
Tricuspid regurgitation (TR) is a common condition that is independently associated with high mortality rates in patients with heart failure (HF)....
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Device therapy for patients with atrial fibrillation and heart failure with preserved ejection fraction
Device therapy is a nonpharmacological approach that presents a crucial advancement for managing patients with atrial fibrillation (AF) and heart...
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Evidence for a lack of inotropic and chronotropic effects of glucagon and glucagon receptors in the human heart
BackgroundGlucagon is thought to increase heart rate and contractility by stimulating glucagon receptors and increasing 3′,5′-cyclic adenosine...
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Regeneration of the heart: from molecular mechanisms to clinical therapeutics
Heart injury such as myocardial infarction leads to cardiomyocyte loss, fibrotic tissue deposition, and scar formation. These changes reduce cardiac...
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Essential right heart physiology for the perioperative practitioner POQI IX: current perspectives on the right heart in the perioperative period
As patients continue to live longer from diseases that predispose them to right ventricular (RV) dysfunction or failure, many more patients will...
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The Right Heart in Congenital Heart Disease
Purpose of ReviewTo analyze the pathophysiologic importance of the right heart in different types of congenital heart disease (CHD), summarize...
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Pepducin ICL1-9-Mediated β2-Adrenergic Receptor-Dependent Cardiomyocyte Contractility Occurs in a Gi Protein/ROCK/PKD-Sensitive Manner
Purposeβ-Adrenergic receptors (βAR) are essential targets for the treatment of heart failure (HF); however, chronic use of βAR agonists as positive...
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Profiling the Biomechanical Responses to Workload on the Human Myocyte to Explore the Concept of Myocardial Fatigue and Reversibility: Rationale and Design of the POWER Heart Failure Study
It remains unclear why some patients develop heart failure without evidence of structural damage. One theory relates to impaired myocardial...
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Cardiac Contractility Modulation in Heart Failure: Mechanisms and Clinical Evidence
Purpose of reviewDevice-based therapy utilizing cardiac contractility modulation (CCM™) was approved by the FDA in March 2019 for patients with...
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Computational Modeling Studies of the Roles of Left Ventricular Geometry, Afterload, and Muscle Contractility on Myocardial Strains in Heart Failure with Preserved Ejection Fraction
Global longitudinal strain and circumferential strain are found to be reduced in HFpEF, which some have interpreted that the global left ventricular...
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Influence of heart rate on right ventricular function assessed by right heart catheterization and echocardiography in healthy anesthetized dogs
BackgroundRight ventricular (RV) functional assessment has received considerable attention in veterinary medicine since various diseases, such as...
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Milrinone for the treatment of heart failure caused by severe Pneumonia in children with congenital heart disease: a meta-analysis
BackgroundChildren with congenital heart disease (CHD) are easily complicated by severe pneumonia and heart failure. We aimed to conduct a...
