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Efficacy of tocilizumab for refractory Takayasu arteritis: a retrospective study and literature review
To evaluate the efficacy and safety of tocilizumab (TCZ) in the treatment of refractory Takayasu arteritis (TAK). Eleven refractory TAK patients...
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A phase 1 study to assess the absolute bioavailability, mass balance, pharmacokinetics, metabolism, and excretion of [14C]-mobocertinib, an oral inhibitor of EGFR exon 20 insertion mutations, in healthy participants
Mobocertinib (TAK-788) is a first-in-class oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that received accelerated approval...
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Assessing the acceptability and feasibility of reactive drug administration for malaria elimination in a Plasmodium vivax predominant setting: a qualitative study in two provinces in Thailand
BackgroundReactive case detection (RACD) or testing and treatment of close contacts of recent malaria cases, is commonly practiced in settings...
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Tocilizumab treatment effectively improves coronary artery involvement in patients with Takayasu arteritis
ObjectiveCoronary artery involvement in Takayasu arteritis (TAK) leads to poor prognosis and high mortality. Tocilizumab (TCZ) has been used to...
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Near-Infrared Spectroscopy measurements are reliable for studying patellar bone hemodynamics and affected by venous occlusion, but not by skin compression
PurposeAccording to the homeostasis model, patellofemoral pain (PFP) results from disturbed homeostasis due to vascular insufficiency in the anterior...
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Unstable hemoglobin Montreal II uncovered in an adult with unexplained hemolysis exacerbated by a presumed viral infection: a case report
BackgroundUnstable hemoglobinopathies are rare inherited disorders of hemoglobin causing a reduction of hemoglobin molecule solubility. This results...
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Delayed diagnosis of congenital thrombotic thrombocytopenic purpura in a patient with recurrent strokes
Congenital thrombotic thrombocytopenic purpura (cTTP) is caused by ADAMTS13 mutations and associated with high risk of microvascular thrombosis. A...
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Diagnosis of Compound Heterozygous Hb Tak/β-Thalassemia and HbD-Punjab/β-Thalassemia by HbA2 Levels on Capillary Electrophoresis
A misdiagnosis of β-thalassemia carrier in samples with Hb Tak and HbD-Punjab, the β-variants, can be a cause of inappropriate genetic counseling...
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Prevalence of malarial recurrence and hematological alteration following the initial drug regimen: a retrospective study in Western Thailand
BackgroundThe hematological changes following the initial drug regimen has been poorly understood in Thailand. This study was designed to determine...
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Long-term outcomes with rituximab as add-on therapy in severe childhood-onset lupus nephritis
BackgroundLong-term data pertaining to rituximab as add-on therapy in childhood-onset lupus nephritis (cLN) is scarce.
MethodsA retrospective cohort...
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Predictors of tumor necrosis factor inhibitors primary failure in rheumatoid arthritis patients
BackgroundTumor necrosis factor inhibitors (TNFi) have emerged as an efficient therapeutic modality for rheumatoid arthritis (RA). A ratio of...
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Monogenic lupus with homozygous C4A deficiency presenting as bronchiectasis and immune-mediated thrombocytopenia
Monogenic lupus is a subset of lupus caused by single-gene disorders, integrating the paradoxical combination of autoimmunity and immunodeficiency....
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Adverse Cardiovascular Complications following prescription of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors: a propensity-score matched Cohort Study with competing risk analysis
BackgroundProgrammed death-1 (PD-1) and programmed death- ligand 1 (PD-L1) inhibitors, such as pembrolizumab, nivolumab and atezolizumab, are major...
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Size Distribution of Fragments by High-power Holmium Laser Lithotripsy in MiniPCNL with Suction
Purpose of ReviewData are lacking on distribution of size of fragments created with the laser lithotripsy, stone density, and composition. Dust...
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Clinical profile of bloodstream infections in COVID-19 patients: a retrospective cohort study
BackgroundBloodstream infections (BSIs) are an emerging cause of significant morbidity and mortality in severe Coronavirus disease 2019 (COVID-19)....
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Exergames for balance dysfunction in neurological disability: a meta-analysis with meta-regression
ObjectiveTo evaluate systematically the efficacy of exergames for balance dysfunction in neurological conditions and to identify factors of...
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Polysaccharide of Alocasia cucullata Exerts Antitumor Effect by Regulating Bcl-2, Caspase-3 and ERK1/2 Expressions during Long-Time Administration
ObjectiveTo study the in vitro and in vivo antitumor effects of the polysaccharide of Alocasia cucullata (PAC) and the underlying mechanism.
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Monoclonal antibody applications in travel medicine
For decades, immunoglobulin preparations have been used to prevent or treat infectious diseases. Since only a few years, monoclonal antibody...
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Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium in inflammation caused by SARS-CoV-2
The COVID-19 pandemic has caused numerous deaths around the world. A growing body of evidence points to the important role of overwhelming...