Search
Search Results
-
Alginate-based 3D cell culture technique to evaluate the half-maximal inhibitory concentration: an in vitro model of anticancer drug study for anaplastic thyroid carcinoma
BackgroundThree-dimensional (3D) cell culture methods are identified for simulating the biological microenvironment and demonstrating more similarity...
-
Proliferation Inhibitory Activity of Quinones from Blaps rynchopetera Defense Secretion on Colorectal Tumor Cells
ObjectiveTo explore the proliferation inhibitory effect of quinones from Blaps rynchopetera defense secretion on colorectal tumor cell lines.
... -
Comparison of inhibitory activities of 50 Salvia species against α-Glucosidase
ObjectivesType 2 diabetes is a common metabolic disease affecting millions of people worldwide. α-Glucosidase inhibitors can be used as one of the...
-
New bakuchiol dimers from Psoraleae Fructus and their inhibitory activities on nitric oxide production
BackgroundDried fruits of Psoralea corylifolia L. ( Psoraleae Fructus ) is one of the most popular traditional Chinese medicine with treatment for...
-
An integrated microfluidics platform with high-throughput single-cell cloning array and concentration gradient generator for efficient cancer drug effect screening
BackgroundTumor cell heterogeneity mediated drug resistance has been recognized as the stumbling block of cancer treatment. Elucidating the...
-
N6-methyladenosine (m6A) writer KIAA1429 accelerates gastric cancer oxaliplatin chemoresistance by targeting FOXM1
PurposeChemical modification plays a critical role in regulating human cancer progression, especially N 6 -methyladenosine (m 6 A). However, m 6 A writer...
-
Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation
BackgroundMacrophage migration inhibitory factor (MIF) and GTPase dynamin-related protein 1 (Drp1)-dependent aberrant mitochondrial fission are...
-
m6A-modified circARHGAP12 promotes the aerobic glycolysis of doxorubicin-resistance osteosarcoma by targeting c-Myc
Chemotherapy resistance accompanied by energy metabolism abnormality functions as one of the main reasons for treatment failure and poor prognosis....
-
Investigation of the activity of baicalein towards Zika virus
BackgroundZika virus (ZIKV) is a mosquito transmitted virus spread primarily by Aedes species mosquitoes that can cause disease in humans,...
-
Dynamics of γ-aminobutyric acid concentration in the human brain in response to short visual stimulation
ObjectiveTo find a possible quantitative relation between activation-induced fast (< 10 s) changes in the γ-aminobutyric acid (GABA) level and the...
-
The influence of plant extracts on viability of ST3 and ST7 subtypes of Blastocystis sp.
Blastocystis sp. is one of the most frequently detected protozoa during stool specimen examination. In the last decade, the studies about the...
-
Combining lapatinib and palbociclib inhibits cell proliferation and invasion via AKT signaling pathway in endocrine-resistant breast cancer cells
Endocrine therapy plays a critical role in patients with hormone receptor-positive breast cancer. Endocrine-resistant breast cancer cells exhibit...
-
Tapinarof Cream 1% for Extensive Plaque Psoriasis: A Maximal Use Trial on Safety, Tolerability, and Pharmacokinetics
BackgroundTapinarof is a novel topical therapeutic aryl hydrocarbon receptor modulating agent in development for the treatment of psoriasis and...
-
Therapeutic Potential of Thunbergia laurifolia L. Extract in Gestational Diabetes Mellitus: Insights from a Rat Model
ObjectiveTo assess the effects of Thunbergia laurifolia L. extract (TLE) on gestational diabetes mellitus (GDM) in a rat model.
Methods ... -
The cytotoxicity of γδT cells in non-small cell lung cancer mediated via coordination of the BCL-2 and AKT pathways
The effectiveness and mechanisms of γδ T-cell immunotherapy in lung cancer remain unclear. In this study, we assessed the effects of continuous,...
-
Transporter modulation of molnupiravir and its metabolite β-D-N4-hydroxycytidine across the blood-brain barrier in a rat
BackgroundThe antiviral drug molnupiravir is an orally bioavailable prodrug of the nucleoside analog β-D-N4-hydroxycytidine (NHC), which is used to...
-
The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration
There is a pressing need to accelerate therapeutic strategies against the syndromes caused by frontotemporal lobar degeneration, including...
-
Mechanism of Gentisic Acid on Rheumatoid Arthritis Based on miR-19b-3p/RAF1 Axis
ObjectiveTo investigate the therapeutic effect of gentisic acid (GA) on rheumatoid arthritis (RA) based on the miR-19b-3p/RAF1 axis.
Methods ... -
3D Microfluidic System for Evaluating Inhibitory Effect of Chinese Herbal Medicine Oldenlandia diffusa on Human Malignant Glioma Invasion Combined with Network Pharmacology Analysis
ObjectiveTo investigate the anti-invasion efficacy of the ethanol extract of Oldenlandia diffusa Will. (EEOD) on a three-dimensional (3D) human...
-
Cytotoxic screening and in vitro effect of sodium chlorite against Leishmania major promastigotes
Cutaneous leishmaniasis (CL) is one of the most important parasitic diseases in the world. Despite the existence of many therapeutic strategies, the...
