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The role of the BTLA–HVEM complex in the pathogenesis of breast cancer
Breast cancer (BC) is widely recognized as a prevalent contributor to cancer mortality and ranks as the second most prevalent form of cancer among...
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Expression of LIGHT/TNFSF14 and Its Receptors, HVEM and LTβR, Correlates with the Severity of Fibrosis in Lacrimal Sacs from Patients with Lacrimal Duct Obstruction
IntroductionFibrosis is one of the factors contributing to the development of primary acquired lacrimal duct obstruction (LDO). LIGHT (homologous to...
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HVEM/HIF-1α promoted proliferation and inhibited apoptosis of ovarian cancer cells under hypoxic microenvironment conditions
BackgroundOur previous studies showed the expression of herpes virus entry mediator (HVEM) is high in ovarian cancer samples and correlated to the...
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BTLA dysregulation correlates with poor outcome and diminished T cell-mediated antitumor responses in chronic lymphocytic leukemia
Patients with chronic lymphocytic leukemia (CLL) progressively develop marked immunosuppression, dampening innate and adaptive-driven antitumor...
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Normofractionated irradiation and not temozolomide modulates the immunogenic and oncogenic phenotype of human glioblastoma cell lines
PurposeGlioblastoma multiforme (GBM) is the most aggressive primary brain tumor, with an overall poor prognosis after diagnosis. Conventional...
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Associations between CD160 polymorphisms and autoimmune thyroid disease: a case-control study
BackgroundRecent researches suggest that the CD160/HVEM/LIGHT/BTLA signaling pathway may contribute to the pathogeneses of autoimmune diseases, but...
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The kinetics of inhibitory immune checkpoints during and post-COVID-19: the knowns and unknowns
The immune system is tightly regulated to prevent immune reactions to self-antigens and to avoid excessive immune responses during and after...
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Current Approaches of Immune Checkpoint Therapy in Chronic Lymphocytic Leukemia
Increasing understanding of the complex interaction between leukemic and immune cells, which is responsible for tumor progression and immune evasion,...
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Effects of immune cells in mediating the relationship between gut microbiota and myelodysplastic syndrome: a bidirectional two-sample, two-step Mendelian randomization study
BackgroundThe definitive establishment of a causal relationship between gut microbiota and myelodysplastic syndrome (MDS) has not been achieved....
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A novel disulfidptosis-related immune checkpoint genes signature: forecasting the prognosis of hepatocellular carcinoma
BackgroundHCC is an extremely malignant tumor with a very poor prognosis. In 2023, a brand-new kind of cell death known as disulfidptosis was...
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Significance of Herpesvirus Entry Mediator Expression in Human Colorectal Liver Metastasis
BackgroundHerpesvirus entry mediator (HVEM) has been suggested to play various roles in cancer biology. The authors report that HVEM expression in...
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Immune checkpoints in cardiac physiology and pathology: therapeutic targets for heart failure
Immune checkpoint molecules are physiological regulators of the adaptive immune response. Immune checkpoint inhibitors (ICIs), such as monoclonal...
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The soluble form of CD160 acts as a tumor mediator of immune escape in melanoma
Melanoma is responsible for 90% of skin cancer-related deaths. Major therapeutic advances have led to a considerable improvement in the prognosis of...
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Investigating the causal relationship between immune cell and Alzheimer’s disease: a mendelian randomization analysis
BackgroundComplex interactions between the immune system and the brain may affect neural development, survival, and function, with etiological and...
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Characterization of multiple soluble immune checkpoints in individuals with different Mycobacterium tuberculosis infection status and dynamic changes during anti-tuberculosis treatment
BackgroundImmune checkpoints are crucial for the maintenance of subtle balance between self-tolerance and effector immune responses, but the role of...
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Identification of allograft inflammatory factor-1 suppressing the progression and indicating good prognosis of osteosarcoma
BackgroundOsteosarcoma is one of the most common cancers worldwide. Intense efforts have been made to elucidate the pathogeny, but the mechanisms of...
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A case report of long-delayed diagnosis of pseudorabies virus encephalitis with endophthalmitis: lessons from metagenomic next generation sequencing
BackgroundPseudorabies virus (PRV) was thought to only infect animals. Recent studies have shown that it can also infect human.
Case presentation ...
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Serum immune checkpoint profiling identifies soluble CD40 as a biomarker for pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) responds poorly to systemic treatment, including new immunotherapeutic approaches. Biomarkers are urgently...
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A prognostic gene signature for gastric cancer and the immune infiltration-associated mechanism underlying the signature gene, PLG
BackgroundGlobally, gastric cancer (GC) is a common and lethal solid malignant tumor. Identifying the molecular signature and its functions can...
