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Rapid screening of riot control agents using DART-TD-HRMS
PurposeRiot Control Agents (RCAs) are chemicals used in law enforcement for non-lethal riot control and use in conflicts between states that violates...
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Rapid identification of chemical components in Xuelian granule by UHPLC-Q-orbitrap-HRMS based on enzyme activity in vitro
BackgroundXuelian granule (XL), a traditional Chinese medicine (TCM) formula, has been used for the treatment of diabetic nephropathy for a long time...
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Rapid quantification of phenobarbital and barbital in human whole blood by liquid–liquid extraction combined with DART-orbitrap-HRMS
PurposeThis study aims to develop and validate a rapid, simple, and efficient bioanalytical method for the simultaneous quantification of...
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Exploring the antimicrobial activity of Origanum majorana L. against the highly virulent multidrug-resistant Acinetobacter baumannii AB5075: UPLC-HRMS profiling with in vitro and in silico studies
BackgroundThe infamous multidrug-resistant (MDR) bacterium Acinetobacter baumannii is becoming a nightmare in intensive care units across the globe....
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Metabolic bioprofiling of different Glycyrrhiza glabra solvent fractions for the identification of anti-adenoviral compounds using LC-HRMS/MS and in-vitro cytopathic assay coupled with chemometry
Human adenovirus type-7 (HAdV-7) is a common pathogen that may cause significant morbidity as well as severe complications. Currently, there is no...
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Development of LC-HRMS untargeted analysis methods for nasal epithelial lining fluid exposomics
BackgroundThe nasal mucosa, as a primary site of entry for inhaled substances, contains both inhaled xenobiotic and endogenous biomarkers. Nasal...
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Detection of insulins in postmortem tissues: an optimized workflow based on immunopurification and LC–MS/HRMS detection
Diabetes is a worldwide disease in perpetual expansion. Type 1 and sometimes type 2 diabetic patients require daily human insulin (HI) or analog...
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An HPLC and UHPLC-HRMS approach to study PSMA-11 instability in aqueous solution
BackgroundThe stability of precursors and reagents is of utmost importance for develo** a robust radiolabelling method that provides high and...
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The combination of UHPLC-HRMS and molecular networking improving discovery efficiency of chemical components in Chinese Classical Formula
BackgroundIt is essential to identify the chemical components for the quality control methods establishment of Chinese Classical Formula (CCF)....
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Non-targeted analysis (NTA) and suspect screening analysis (SSA): a review of examining the chemical exposome
AbstractNon-targeted analysis (NTA) and suspect screening analysis (SSA) are powerful techniques that rely on high-resolution mass spectrometry...
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Measurement of hydroxychloroquine in blood from SLE patients using LC-HRMS—evaluation of whole blood, plasma, and serum as sample matrices
BackgroundHydroxychloroquine (HCQ) is the standard of care in the treatment of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and...
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Practical application guide for the discovery of novel PFAS in environmental samples using high resolution mass spectrometry
BackgroundThe intersection of the topics of high-resolution mass spectrometry (HRMS) and per- and polyfluoroalkyl substances (PFAS) bring together...
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Effects of Corsi-Rosenthal boxes on indoor air contaminants: non-targeted analysis using high resolution mass spectrometry
BackgroundIn response to COVID-19, attention was drawn to indoor air quality and interventions to mitigate airborne COVID-19 transmission. Of...
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Analytical characterization and differentiation between threo- and erythro-4-fluoroethylphenidate
PurposeMethylphenidate analogs appeared on the drug market during the last years. Its analogs contain two chiral centers and, thus, have potential...
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Combined ambient ionization mass spectrometric and chemometric approach for the differentiation of hemp and marijuana varieties of Cannabis sativa
BackgroundHemp and marijuana are the two major varieties of Cannabis sativa . While both contain Δ 9 -tetrahydrocannabinol (THC), the primary...
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Network module analysis and molecular docking-based study on the mechanism of astragali radix against non-small cell lung cancer
BackgroundMost lung cancer patients worldwide (stage IV non-small cell lung cancer, NSCLC) have a poor survival: 25%-30% patients die < 3 months....
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Integrating different tools and technologies to advance drinking water quality exposure assessments
Contaminants in drinking water are a major contributor to the human exposome and adverse health effects. Assessing drinking water exposure accurately...
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Identification of 1-(thiophene-2-carbonyl)-LSD from blotter paper falsely labeled “1D-LSD”
PurposeSince the mid-2010s, lysergic acid diethylamide (LSD) analogs made for substance abuse have periodically emerged. In this case, three pieces...
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Decoction regulating phytochemicals’ micromorphology changes and anti-inflammation activity enhancements originated from herb medicine supermolecules
BackgroundMahuang Fuzi decoction (MGF) is composed of three herb medicines that has been clinically used to treat inflammatory diseases for a long...
