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1. Therapeutic Role of Chinese Medicine Targeting Nrf2/HO-1 Signaling Pathway in Myocardial Ischemia/Reperfusion Injury

   Acute myocardial infarction (AMI), characterized by high incidence and mortality rates, poses a significant public health threat. Reperfusion...

   Chang-xing Liu, **n-yi Guo, ... He Wang in Chinese Journal of Integrative Medicine

   Article 08 February 2024

2. Novel methyltransferase G9a inhibitor induces ferroptosis in multiple myeloma through Nrf2/HO-1 pathway

   Multiple myeloma (MM) is a common malignant hematologic neoplasm, and the involvement of epigenetic modifications in its development and drug...

   Yu Zhang, **aoshun Wang, ... Lijuan Wang in Annals of Hematology

   Article 27 March 2024
   

3. Neuroprotective effect of acetoxypachydiol against oxidative stress through activation of the Keap1-Nrf2/HO-1 pathway

   Background

   Excessive oxidative stress in the brain is an important pathological factor in neurological diseases. Acetoxypachydiol (APHD) is a...

   Yu Qi, Ge Liu, ... Pengcheng Yan in BMC Complementary Medicine and Therapies

   Article Open access 25 April 2024
   

4. Cyclophosphamide induces ovarian granulosa cell ferroptosis via a mechanism associated with HO-1 and ROS-mediated mitochondrial dysfunction

   Abnormal granulosa cell (GC) death contributes to cyclophosphamide (CTX) induced primary ovarian insufficiency (POI). To investigate the contribution...

   Hui Chen, ** Nie, ... ** Li in Journal of Ovarian Research

   Article Open access 18 May 2024
   

5. Maresin-1 inhibits high glucose induced ferroptosis in ARPE-19 cells by activating the Nrf2/HO-1/GPX4 pathway

   Background

   Maresin-1 plays an important role in diabetic illnesses and ferroptosis is associated with pathogenic processes of diabetic retinopathy...

   Yufei Li, Jieyu Liu, ... Xue Bai in BMC Ophthalmology

   Article Open access 06 September 2023
   

6. Metformin induces ferroptosis through the Nrf2/HO-1 signaling in lung cancer

   Background

   Metformin is the most frequently prescribed medication for the treatment of type II diabetes mellitus and has played an anti-tumor...

   Chengmin Deng, Lin **ong, ... Jie Wu in BMC Pulmonary Medicine

   Article Open access 25 September 2023
   

7. The deubiquitinase USP7 regulates oxidative stress through stabilization of HO-1

   Heme oxygenase-1 (HO-1) is an inducible heme degradation enzyme that plays a cytoprotective role against various oxidative and inflammatory stresses....

   Ming Gao, Zijuan Qi, ... **xiang Han in Oncogene

   Article 11 July 2022
   

8. Nrf2/HO-1 signaling activation alleviates cigarette smoke-induced inflammation in chronic obstructive pulmonary disease by suppressing NLRP3-mediated pyroptosis

   Background

   This study examined the effect of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway on chronic...

   Yanan Zhang, **xia Wang, ... Kai Lei in Journal of Cardiothoracic Surgery

   Article Open access 05 February 2024
   

9. Allicin protects against LPS-induced cardiomyocyte injury by activating Nrf2-HO-1 and inhibiting NLRP3 pathways

   Background

   Allicin is a bioactive compound with potent antioxidative activity and plays a protective effect in myocardial damage and fibrosis. The...

   Fangyuan Sun, Kailiang Xu, ... Ming Lei in BMC Cardiovascular Disorders

   Article Open access 18 August 2023
   

10. Huangqin Decoction Delays Progress of Colitis-Associated Carcinogenesis by Regulating Nrf2/HO-1 Antioxidant Signal Pathway in Mice

    Objective

    To investigate the effect of Huangqin Decoction (HQD) on nuclear factor erythroid 2 related-factor 2 (Nrf2)/heme oxygenase (HO-1) signaling...

    Li-mei Gu, He-zhong Li, ... Yao-zhou Tian in Chinese Journal of Integrative Medicine

    Article 12 July 2023

11. ETS1 Ameliorates Hyperoxia-Induced Bronchopulmonary Dysplasia in Mice by Activating Nrf2/HO-1 Mediated Ferroptosis

    Purpose

    Bronchopulmonary dysplasia (BPD) is associated with hyperoxia-induced oxidative stress-associated ferroptosis. This study examined the effect...

    Min Yang, Yan** Chen, ... Yanni Meng in Lung

    Article Open access 25 July 2023
    

12. Tetramethylpyrazine ameliorates endotoxin-induced acute lung injury by relieving Golgi stress via the Nrf2/HO-1 signaling pathway

    Purpose

    Endotoxin-induced acute lung injury (ALI) is a severe disease caused by an imbalanced host response to infection. It is necessary to explore...

    Shaona Li, Yexiang Xu, ... Jianbo Yu in BMC Pulmonary Medicine

    Article Open access 07 August 2023
    

13. Unveiling the potent effect of vitamin D: harnessing Nrf2/HO-1 signaling pathways as molecular targets to alleviate urban particulate matter-induced asthma inflammation

    Background

    Asthma is the most common allergic disease characterized by an inflammatory response in the airways. Mechanismly, urban particulate matter...

    Dandan Ge, Qihong Chen, ... Yungang Yang in BMC Pulmonary Medicine

    Article Open access 25 January 2024
    

14. Paeoniflorin alleviates hypoxia/reoxygenation injury in HK-2 cells by inhibiting apoptosis and repressing oxidative damage via Keap1/Nrf2/HO-1 pathway

    Acute kidney injury (AKI) is a serious disorder associated with significant morbidity and mortality. AKI and ischemia/reperfusion...

    Di **ng, Yihua Ma, ... Hongli Zhou in BMC Nephrology

    Article Open access 26 October 2023
    

15. Aerobic exercise improves BK_Ca channel-mediated vasodilation in diabetic vascular smooth muscle via AMPK/Nrf2/HO-1 pathway

    Aims

    This study aims to investigate the effect of aerobic exercise training on BK _Ca channel in diabetic vascular smooth muscle and explore the...

    Yujia Liu, Yue Cheng, ... **ngqi Wang in Acta Diabetologica

    Article 02 December 2023
    

16. Platycodon D protects human nasal epithelial cells from pyroptosis through the Nrf2/HO-1/ROS signaling cascade in chronic rhinosinusitis

    Background

    Pyroptosis has been demonstrated being closely associated with the inflammatory progression in chronic rhinosinusitis (CRS). However,...

    Ruizhi Wang, Yongchun Wang, ... Min Zhou in Chinese Medicine

    Article Open access 04 March 2024
    

17. Glycyrrhizin Ameliorates Cardiac Injury in Rats with Severe Acute Pancreatitis by Inhibiting Ferroptosis via the Keap1/Nrf2/HO-1 Pathway

    Background

    Severe acute pancreatitis (SAP) is a potential fatal gastrointestinal disease that is usually complicated by myocardial injury and...

    Qingrui Cui, Wei Wang, ... Yuke **ang in Digestive Diseases and Sciences

    Article 16 May 2024
    

18. The dual role and mutual dependence of heme/HO-1/Bach1 axis in the carcinogenic and anti-carcinogenic intersection

    Introduction

    In physiological concentrations, heme is nontoxic to the cell and is essential for cell survival and proliferation. Increasing...

    ****g Xu, Kuiyang Zhu, ... **g Chen in Journal of Cancer Research and Clinical Oncology

    Article 31 October 2022
    

19. The effect of extracorporeal shock wave on joint capsule fibrosis based on A₂AR-Nrf2/HO-1 pathway in a rat extending knee immobilization model

    Joint capsule fibrosis, a common complication of joint immobilization, is mainly characterized by abnormal collagen deposition. The present study...

    Hai Yuan, Kui Wang, ... Yun Zhou in Journal of Orthopaedic Surgery and Research

    Article Open access 06 December 2023
    

20. Protective effects of the Terminalia bellirica tannin-induced Nrf2/HO-1 signaling pathway in rats with high-altitude pulmonary hypertension

    Background

    Oxidative stress and endothelial cell dysfunction induced by high-altitude hypoxia have important roles in the pathological process of...

    Salamaiti Aimaier, Yang Tao, ... Dilinuer Maimaitiyiming in BMC Complementary Medicine and Therapies

    Article Open access 06 May 2023