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Community engagement group model in basic and biomedical research: lessons learned from the BEAT-HIV Delaney Collaboratory towards an HIV-1 cure
IntroductionAchieving effective community engagement has been an objective of U.S. National Institutes of Health-funded HIV research efforts,...
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The Importance of Social Engagement in the Development of an HIV Cure: A Systematic Review of Stakeholder Perspectives
As research into the development of an HIV cure gains prominence, assessing the perspectives of stakeholders becomes imperative. It empowers...
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Learning from Persistent Viremia: Mechanisms and Implications for Clinical Care and HIV-1 Cure
Purpose of ReviewIn this review, we discuss what persistent viremia has taught us about the biology of the HIV-1 reservoir during antiretroviral...
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More than the Infinite Monkey Theorem: NHP Models in the Development of a Pediatric HIV Cure
Purpose of ReviewAn HIV cure that eliminates the viral reservoir or provides viral control without antiretroviral therapy (ART) is an urgent need in...
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The estimation of long and short term survival time and associated factors of HIV patients using mixture cure rate models
BackgroundHIV is one of the deadliest epidemics and one of the most critical global public health issues. Some are susceptible to die among people...
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HIV-1 Reservoir Persistence and Decay: Implications for Cure Strategies
Purpose of ReviewDespite suppressive antiretroviral therapy (ART), a viral reservoir persists in individuals living with HIV that can reignite...
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Awareness of HIV functional cure and willingness in participating in related clinical trials: comparison between antiretroviral naïve and experienced men who have sex with men living with HIV
BackgroundHuman immunodeficiency virus (HIV) functional cure is a novel biomedical strategy characterized by sustained viral suppression without the...
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HCV cure: an appropriate moment to reduce cannabis use in people living with HIV? (ANRS CO13 HEPAVIH data)
BackgroundThanks to direct-acting antivirals, hepatitis C virus (HCV) infection can be cured, with similar rates in HCV-infected and HIV–HCV...
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Considerations for designing and implementing combination HIV cure trials: findings from a qualitative in-depth interview study in the United States
BackgroundAn increasing number of HIV cure trials involve combining multiple potentially curative interventions. Until now, considerations for...
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Advances in HIV Research Using Mass Cytometry
Purpose of ReviewThis review describes how advances in CyTOF and high-dimensional analysis methods have furthered our understanding of HIV...
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HIV Compartmentalization in the CNS and Its Impact in Treatment Outcomes and Cure Strategies
Purpose of ReviewThis review focuses on the cerebrospinal fluid (CSF) findings in connection to the central nervous system (CNS) reservoir in...
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Acceptability, motivation and the prospect of cure for people living with HIV and their healthcare providers in HIV cure-focused treatment interruption studies
BackgroundAnalytical treatment interruptions (ATI) are commonly used clinical endpoints to assess interventions aimed at curing HIV or achieving...
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HIV-1 Myeloid Reservoirs — Contributors to Viral Persistence and Pathogenesis
Purpose of ReviewHIV reservoirs are the main barrier to cure. CD4+ T cells have been extensively studied as the primary HIV-1 reservoir. However,...
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HIV infection
The AIDS epidemic has been a global public health issue for more than 40 years and has resulted in ~40 million deaths. AIDS is caused by the...
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Breakthroughs in hepatitis C research: from discovery to cure
In the 1970s, an unknown virus was suspected for documented cases of transfusion-associated hepatitis, a phenomenon called non-A, non-B hepatitis. In...
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HIV Reservoir: How to Measure It?
Purposeof ReviewIn the current quest for a complete cure for HIV/AIDS, the persistence of a long-lived reservoir of cells carrying...
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Specific quantification of inducible HIV-1 reservoir by RT-LAMP
BackgroundStrategies toward HIV-1 cure aim to clear, inactivate, reduce, or immunologically control the virus from a pool of latently infected cells...
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Early elevated IFNα is a key mediator of HIV pathogenesis
BackgroundA complete understanding of the different steps of HIV replication and an effective drug combination have led to modern antiretroviral...
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Lessons for Understanding Central Nervous System HIV Reservoirs from the Last Gift Program
Purpose of ReviewDeep tissue HIV reservoirs, especially within the central nervous system (CNS), are understudied due to the challenges of sampling...
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High cure rates of Mycoplasma genitalium following empiric treatment with azithromycin alongside frequent detection of macrolide resistance in Austria
BackgroundMycoplasma genitalium (MG) is an emerging sexually transmitted infection, often harboring resistance-associated mutations to azithromycin...
