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A novel entity of HIPK2::YAP1 pulmonary fibromatosis
BackgroundPulmonary fibromatosis (PF) is a specific variant of fibromatosis, which is rarely reported occurring in the lung. PF with HIPK2-YAP1 ...
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Adipose-derived stem cell exosome NFIC improves diabetic foot ulcers by regulating miR-204-3p/HIPK2
BackgroundDiabetic foot ulcers (DFU) are a serious complication of diabetes that lead to significant morbidity and mortality. Recent studies reported...
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MiR-423-5p activated by E2F1 promotes neovascularization in diabetic retinopathy by targeting HIPK2
BackgroundDiabetic retinopathy (DR) is a diabetic complication and the primary cause of blindness in the world. However, the treatments of DR are...
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Circ_0025908 regulates cell vitality and proliferation via miR-137/HIPK2 axis of rheumatic arthritis
BackgroundRheumatic arthritis (RA) is an autoimmune disease with bad effects. Recent researches have shown that circular RNAs (circRNAs) could affect...
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CircASH2L facilitates tumor-like biologic behaviours and inflammation of fibroblast-like synoviocytes via miR-129-5p/HIPK2 axis in rheumatoid arthritis
BackgroundPrevious study showed that circular RNA Absent-Small-Homeotic-2--Like protein (circASH2L) was higher in rheumatoid arthritis (RA) patients....
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HMGB1-induced activation of ER stress contributes to pulmonary artery hypertension in vitro and in vivo
BackgroundHMGB1 and ER stress have been considered to participate in the progression of pulmonary artery hypertension (PAH). However, the molecular...
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Epigenetic silencing of LncRNA LINC00261 promotes c-myc-mediated aerobic glycolysis by regulating miR-222-3p/HIPK2/ERK axis and sequestering IGF2BP1
Long noncoding RNAs have been identified as key regulators in the progression of various cancers. LINC00261 has been reported as a tumor suppressor...
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HIPK2 suppresses tumor growth and progression of hepatocellular carcinoma through promoting the degradation of HIF-1α
Aberrant angiogenesis of hepatocellular carcinoma (HCC) leads to tumor growth and local or distant metastasis. Uncovering the underlying mechanisms...
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CircHIPK2 facilitates phenotypic switching of vascular smooth muscle cells in hypertension
Hypertension is a clinical syndrome characterized by increased systemic arterial blood pressure, affecting about 1.4 billion people currently...
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Oral vitamin D supplementation induces transcriptomic changes in rectal mucosa that are linked to anti-tumour effects
BackgroundThe risk for several common cancers is influenced by the transcriptomic landscape of the respective tissue-of-origin. Vitamin D influences...
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HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis
Cytokinesis, the final phase of cell division, is necessary to form two distinct daughter cells with correct distribution of genomic and cytoplasmic...
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The Role and Potential Mechanisms of Rehabilitation Exercise Improving Cardiac Remodeling
Rehabilitation exercise is a crucial non-pharmacological intervention for the secondary prevention and treatment of cardiovascular diseases,...
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The regulation roles of miRNAs in Helicobacter pylori infection
Helicobacter pylori is a kind of Gram-negative bacteria that parasitizes on human gastric mucosa. Helicobacter pylori infection is very common in...
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Functional characterization of two DYRK1B variants causative of AOMS3
BackgroundTwo new missense variants (K68Q and R252H) of the protein kinase DYRK1B were recently reported to cause a monogenetic form of metabolic...
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Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics
Exercise training has been widely recognized as a healthy lifestyle as well as an effective non-drug therapeutic strategy for cardiovascular diseases...
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A comprehensive survey into the role of microRNAs in ovarian cancer chemoresistance; an updated overview
Ovarian cancer (OC), a frequent malignant tumor that affects women, is one of the leading causes of cancer-related death in this group of...
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The mechanistic insights of the antioxidant Keap1-Nrf2 pathway in oncogenesis: a deadly scenario
The Nuclear factor erythroid 2-related factor 2 (Nrf2) protein has garnered significant interest due to its crucial function in safeguarding cells...
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Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses
Homeodomain interacting protein kinase-2 (HIPK2) is a member of the HIPK family of stress-responsive kinases that modulates cell growth, apoptosis,...
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Cell line models for drug discovery in PIK3CA-mutated colorectal cancers
Colorectal cancer remains a major cause of cancer-related morbidity and mortality. Metastatic disease is still incurable in most cases. New therapies...
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Sirtuins in kidney health and disease
Sirtuins (SIRTs) are putative regulators of lifespan in model organisms. Since the initial discovery that SIRTs could promote longevity in nematodes...
