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Protective effect of HINT2 on mitochondrial function via repressing MCU complex activation attenuates cardiac microvascular ischemia–reperfusion injury
Current evidence indicates that coronary microcirculation is a key target for protecting against cardiac ischemia–reperfusion (I/R) injury....
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Genome-wide epistasis study highlights genetic interactions influencing severity of COVID-19
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may lead to life-threatening...
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Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine
Cancer is one of the major diseases threatening human life and health worldwide. Epigenetic modification refers to heritable changes in the genetic...
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Roles of METTL3 in cancer: mechanisms and therapeutic targeting
N 6 -methyladenosine (m 6 A) is the most abundant mRNA modification and is catalyzed by the methyltransferase complex, in which methyltransferase-like 3...
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m6A-binding proteins: the emerging crucial performers in epigenetics
N 6 -methyladenosine (m 6 A) is a well-known post-transcriptional modification that is the most common type of methylation in eukaryotic mRNAs. The...
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Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes
The splicing factor SF3B1 is the most frequently mutated gene in myelodysplastic syndromes (MDS), and is strongly associated with the presence of...
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Bottom-up proteomics suggests an association between differential expression of mitochondrial proteins and chronic fatigue syndrome
Chronic fatigue syndrome (CFS) is a debilitating and complex disorder characterized by unexplained fatigue not improved by rest. An area of...
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Increased abundance of translation machinery in stem cell–derived neural progenitor cells from four schizophrenia patients
The genetic and epigenetic factors contributing to risk for schizophrenia (SZ) remain unresolved. Here we demonstrate, for the first time, perturbed...
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Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells
The splicing factor SF3B1 is the most commonly mutated gene in the myelodysplastic syndrome (MDS), particularly in patients with refractory anemia...
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Differences in cumulus cells gene expression between modified natural and stimulated in vitro fertilization cycles
PurposeThe aim of our study was to determine whether there are any differences in the cumulus cell gene expression profile of mature oocytes derived...
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Physical activity and breast cancer survival: an epigenetic link through reduced methylation of a tumor suppressor gene L3MBTL1
The study was conducted to determine the effect of physical activity on DNA methylation and to predict the consequence of this effect concerning gene...
