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Viral, genetic, and immune factors in the oncogenesis of adult T-cell leukemia/lymphoma
Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature CD4 + T cells induced by human T-cell leukemia virus type I (HTLV-1). HTLV-1 maintains...
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Human T-cell lymphotropic virus type 1 (HTLV-1) proposed vaccines: a systematic review of preclinical and clinical studies
BackgroundNumerous vaccination research experiments have been conducted on non-primate hosts to prevent or control HTLV-1 infection. Therefore,...
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Adult T-Cell Leukemia: a Comprehensive Overview on Current and Promising Treatment Modalities
Purpose of the ReviewAdult T-cell leukemia (ATL) is an aggressive chemo-resistant malignancy secondary to HTLV-1 retrovirus. Prognosis of ATL remains...
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3,3′,5-Triiodothyroacetic acid (TRIAC) induces embryonic ζ-globin expression via thyroid hormone receptor α
The human ζ-globin gene ( HBZ ) is transcribed in primitive erythroid cells only during the embryonic stages of development. Reactivation of this...
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Stability of HTLV-2 antisense protein is controlled by PML nuclear bodies in a SUMO-dependent manner
Since the identification of the antisense protein of HTLV-2 (APH-2) and the demonstration that APH-2 mRNA is expressed in vivo in most HTLV-2...
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Super-enhancers: critical roles and therapeutic targets in hematologic malignancies
Super-enhancers (SEs) in a broad range of human cell types are large clusters of enhancers with aberrant high levels of transcription factor binding,...
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HTLV-1 bZIP factor protein targets the Rb/E2F-1 pathway to promote proliferation and apoptosis of primary CD4+ T cells
Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus that induces a fatal T-cell malignancy, adult T-cell leukemia (ATL). Among...
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Metabolic reprogramming: a hallmark of viral oncogenesis
More than 1 in 10 cases of cancer in the world are due to chronic viral infections. Viruses induce oncogenesis by targeting the same pathways known...
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E2F8 promotes hepatic steatosis through FABP3 expression in diet-induced obesity in zebrafish
BackgroundDiet-induced hepatic steatosis is highly associated with nonalcoholic fatty liver disease, which is related to the development of metabolic...
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HTLV-1 bZIP factor dysregulates the Wnt pathways to support proliferation and migration of adult T-cell leukemia cells
Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia (ATL). HTLV-1 bZIP factor (HBZ), the viral gene...
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Molecular mechanisms of HTLV-1 infection and pathogenesis
Human T cell leukemia virus type 1 (HTLV-1) is an etiological pathogen of several human diseases, including adult T-cell leukemia (ATL),...
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Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy
The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The...
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TCL1A gene involvement in T-cell prolymphocytic leukemia in Japanese patients
T-cell prolymphocytic leukemia (T-PLL) is a rare type of peripheral T-cell leukemia. In this study, we examined the clinical and biological...
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Multiple facets of junD gene expression are atypical among AP-1 family members
JunD is a versatile AP-1 transcription factor that can activate or repress a diverse collection of target genes. Precise control of junD expression...
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Implication of the HTLV- I bZIP Factor Gene in the Leukemogenesis of Adult T-Cell Leukemia
Adult T-cell leukemia (ATL) is a leukemia derived from CD4 + mature T-cells and induced by human T-cell leukemia virus type I (HTLV-I) infection....
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HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein
Disruption of transcriptional control of cellular genes by human T-cell leukemia virus type-1 (HTLV-1) is thought to be associated, at least in part,...
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T-Cell Control by Human T-Cell Leukemia/Lymphoma Virus Type 1
Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) causes neoplastic transformation of human T-cells in a small number of infected individuals...