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Growth hormone increase by luteinizing hormone-releasing hormone reflects gonadotroph-related characteristics in acromegaly
PurposeWe previously showed the clinical characteristics of acromegaly with a paradoxical growth hormone (GH) response to oral glucose or...
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The modulation of platelet function by growth hormone in growth hormone deficient Hypopituitary patients
BackgroundGrowth hormone deficiency (GHD) has been implicated in increased cardiovascular and cerebrovascular disease risk seen in hypopituitarism,...
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Growth hormone in pediatric chronic kidney disease: more than just height
Recombinant human growth hormone therapy, which was introduced in the 1980s, is now routine for children with advanced chronic kidney disease (CKD)...
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Pituitary Stalk Interruption Syndrome: Analysis of Response to Growth Hormone Therapy
ObjectiveTo analyse the clinical and radiological characteristics of pituitary stalk interruption syndrome (PSIS).
MethodsA retrospective analysis...
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Impact of different growth hormone levels on gut microbiota and metabolism in short stature
BackgroundGrowth hormone deficiency(GHD) and idiopathic short stature(ISS) are the primary causes of short stature in children. Animal experiments...
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Screening of GHSR, GHRHR, GH1 genes in isolated growth hormone deficiency disease in Egyptian patients
BackgroundIsolated growth hormone deficiency (IGHD) is a hereditary disorder that causes significant short stature. GHD has a reported incidence of...
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Clinico-radiological correlation of pituitary stalk interruption syndrome in children with growth hormone deficiency
PurposeTo analyze the clinical, hormonal, and radiological characteristics of Pituitary stalk interruption syndrome (PSIS) in children with growth...
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Epidemiology of growth hormone deficiency in children and adolescents: a systematic review
ObjectiveGrowth hormone deficiency (GHD) is the most common pituitary hormone deficiency and is one of the main causes of short stature in children...
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The Growth Hormone Deficiency (GHD) Reversal Trial: effect on final height of discontinuation versus continuation of growth hormone treatment in pubertal children with isolated GHD—a non-inferiority Randomised Controlled Trial (RCT)
BackgroundGrowth hormone deficiency (GHD) is the commonest endocrine cause of short stature and may occur in isolation (I-GHD) or combined with...
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Growth hormone therapy response in children with short stature
BackgroundShort stature is one of the main causes of children referral to pediatric endocrinologists. Common etiologies include idiopathic growth...
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Psychometric Validation of the Growth Hormone Deficiency–Child Treatment Burden Measure (GHD-CTB) and the Growth Hormone Deficiency–Parent Treatment Burden Measure (GHD-PTB)
PurposeThe aim was to evaluate the measurement properties of the Growth Hormone Deficiency–Child Treatment Burden Measure–Child (GHD-CTB–Child), a...
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Growth patterns and outcomes of growth hormone therapy in patients with acrodysostosis
IntroductionSevere short stature is a feature of acrodysostosis, but data on growth are sparse. Treatment with recombinant human growth hormone...
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New findings on brain actions of growth hormone and potential clinical implications
Growth hormone (GH) is secreted by somatotropic cells of the anterior pituitary gland. The classical effects of GH comprise the stimulation of cell...
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GLP-1 Receptor Agonists Induce Growth Hormone Secretion in Healthy Volunteers
IntroductionGrowth hormone (GH) is an essential regulator of growth, body composition and fuel metabolism and, consequently, GH secretion is under...
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Brain white matter alterations in young adult male patients with childhood-onset growth hormone deficiency: a diffusion tensor imaging study
PurposeThis study aimed to detect white matter changes and different effects of thyroid hormone on the white matter integrity in young adult male...
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Metabolic surgery-induced changes of the growth hormone system relate to improved adipose tissue function
AimsBody weight loss improves insulin resistance and growth hormone secretion in obesity, which may be regulated by leptin according to preclinical...
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Growth hormone and testosterone delay vertebral fractures in boys with muscular dystrophy on chronic glucocorticoids
SummaryGlucocorticoid use in Duchenne and Becker muscular dystrophy prolongs ambulation but cause significant skeletal toxicity. Our analysis has...
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Early psychomotor development and growth hormone therapy in children with Prader-Willi syndrome: a review
Prader-Willi syndrome (PWS) is a rare genetic disorder caused by the loss of imprinted gene expression on the paternal chromosome 15q11-q13. PWS is...
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The outcomes of growth hormone therapy in the obstructive sleep apnea parameters of Prader–Willi syndrome patients: a systematic review
PurposePrader–Willi syndrome is a serious genetic condition, capable of causing endocrinological imbalance, which has as one of its main treatments...
