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Effects of grape seed-derived proanthocyanidin B2 pretreatment on oxidative stress, endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells in renal ischemia–reperfusion injury model of mice
PurposeTo investigate the effect of grape seed-derived proanthocyanidin B2 (GSPB2) pretreatment on acute renal ischemia–reperfusion injury model of...
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Procyanidin B2 induces apoptosis and autophagy in gastric cancer cells by inhibiting Akt/mTOR signaling pathway
BackgroundProcyanidin B2 (PB2), a unique component of the grape seed and other medicinal plants. PB2 has shown wide anticancer activity in various...
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Safety of herbal dietary supplements used for weight loss: sales data and phytovigilance awareness
PurposeOverweight/obesity is a metabolic risk factor contributing to chronic diseases. People use herbal dietary supplements (HDS) to promote weight...
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Phenolic Compounds Promote Diversity of Gut Microbiota and Maintain Colonic Health
The role of non-energy-yielding nutrients on health has been meticulously studied, and the evidence shows that a compound can exert significant...
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Prophylactic effect of flavanol rich preparation metabolites in promoting resilience to a mouse model of social stress
Major depressive disorder (MDD) is a leading cause of disability, and there is an urgent need for new therapeutics. Stress-mediated induction of...
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Masquelier’s grape seed extract: from basic flavonoid research to a well-characterized food supplement with health benefits
Careful characterization and standardization of the composition of plant-derived food supplements is essential to establish a cause-effect...
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Identification of a botanical inhibitor of intestinal diacylglyceride acyltransferase 1 activity via in vitro screening and a parallel, randomized, blinded, placebo-controlled clinical trial
BackgroundDiacylglyceride acyltransferase 1 (DGAT1) is the enzyme that adds the final fatty acid on to a diacylglyceride during triglyceride (TG)...
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Grape seed extract and zinc containing nutritional food supplement prevents onset and progression of age-related cataract in Wistar rats
ObjectiveTo study possible inhibition of oxidative stress and cataract formation by single combined formulation of grape seed extract and Zincovit...
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Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms
Epidemiological, clinical and laboratory studies have implicated solar ultraviolet (UV) radiation in various skin diseases including, premature aging...