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NF-κB in biology and targeted therapy: new insights and translational implications
NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory...
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Pyoderma Gangrenosum: An Updated Literature Review on Established and Emerging Pharmacological Treatments
Pyoderma gangrenosum is a rare inflammatory skin disease classified within the group of neutrophilic dermatoses and clinically characterized by...
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Pathogenesis of allergic diseases and implications for therapeutic interventions
Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD), food allergy (FA), and eczema are systemic diseases...
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Advancing Biologic Therapy for Refractory Autoimmune Hepatitis
Biologic agents may satisfy an unmet clinical need for treatment of refractory autoimmune hepatitis. The goals of this review are to present the...
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Activation of immune signals during organ transplantation
The activation of host’s innate and adaptive immune systems can lead to acute and chronic graft rejection, which seriously impacts graft survival....
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New insights gained from cellular landscape changes in myocarditis and inflammatory cardiomyopathy
Advances in the etiological classification of myocarditis and inflammatory cardiomyopathy (ICM) have reached a consensus. However, the mechanism of...
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Clinical Management of Primary Biliary Cholangitis—Strategies and Evolving Trends
PBC is a chronic progressive autoimmune disorder involving the destruction of intrahepatic small bile ducts, cholestasis, fibrosis, and ultimately...
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Pharmacotherapy for Neuromyelitis Optica Spectrum Disorders: Current Management and Future Options
Neuromyelitis optica (NMO) is an inflammatory and demyelinating disease of the central nervous system. Although the prevalence of NMO is low, the...
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Virotherapy as Potential Adjunct Therapy for Graft-Vs-Host Disease
Purpose of ReviewThis review discusses the pathophysiology, risk factors, and the advances in the prevention or treatment of graft-vs-host disease...
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Clinical Pharmacokinetic and Pharmacodynamic Considerations in the Treatment of Inflammatory Bowel Disease
According to recent clinical consensus, pharmacotherapy of inflammatory bowel disease (IBD) is, or should be, personalized medicine. IBD treatment is...