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Risk of gout in Taiwan Biobank participants pertaining to their sex and family history of gout among first-degree relatives
BackgroundFamily history of gout and sex are independently associated with gout. However, there is a paucity of research regarding the joint role of...
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Clustering of gout-related comorbidities and their relationship with gout flares: a data-driven cluster analysis of eight comorbidities
ObjectivesTo study the aggregation of multiple comorbidities in people with gout and explore differences in prognosis of gout flares among different...
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Correlation between gout and dry eye disease
BackgroundGout is a common form of inflammatory arthritis that can cause a number of serious complications. Complications are common in patients with...
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Pipeline Therapies for Gout
Purpose of ReviewDespite effective available treatments, gout management is often unsuccessful in getting patients to target serum urate goal and in...
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Impact of gout on cardiovascular disease mortality: a meta-analysis
BackgroundSeveral epidemiological studies have suggested that gout patients have a higher risk of cardiovascular disease mortality than healthy...
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Elevated serum IL-2 and Th17/Treg imbalance are associated with gout
Gout is considered an auto-inflammatory disorder, and the immunological drivers have not been fully unraveled. This study compared the peripheral...
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Single-cell and genome-wide Mendelian randomization identifies causative genes for gout
BackgroundGout is a prevalent manifestation of metabolic osteoarthritis induced by elevated blood uric acid levels. The purpose of this study was to...
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Risk of gout flare after medication: prescription symmetry sequence analysis
ObjectivesThe research aimed to study the following questions: (1) five well-known gout-related medications were selected to test the validity of the...
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Mechanisms and rationale for uricase use in patients with gout
Xanthine oxidase inhibitors such as allopurinol and febuxostat have been the mainstay urate-lowering therapy (ULT) for treating hyperuricaemia in...
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Acute gout attacks during the perioperative period and risk factors of recurrence after orthopedic surgery among untreated gout patients
BackgroundThis study aimed to explore the clinical characteristics of perioperative acute gout attacks in patients with varying uric acid levels...
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The clinical benefits of sodium–glucose cotransporter type 2 inhibitors in people with gout
Gout is the most common form of inflammatory arthritis worldwide and is characterized by painful recurrent flares of inflammatory arthritis that are...
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Causal Association Between Tea Consumption and Gout: A Mendelian Randomization Study
ObjectiveEvidence from prospective studies on the consumption of tea and risk of gout is conflicting and limited. We aimed to investigate the...
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Fluctuation and change of serum urate levels and flares in gout: results from the NOR-Gout study
AbstractA gout attack may evolve after a purine-rich diet or alcohol and after starting urate-lowering therapy (ULT). The relationships between...
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Interleukin-37: associations of plasma levels and genetic variants in gout
ObjectivesIL-37 is an anti-inflammatory cytokine involved in inflammatory and autoimmune diseases. We aimed to investigate the association between...
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Benefits of uric acid-lowering medication after bariatric surgery in patients with gout
Background/PurposePatients with gout are at risk for increased serum uric acid (SUA) levels and gout attacks in the short term after undergoing...
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Association between gout and the risk of osteoporosis and fractures: a meta-analysis
ObjectiveThe relationship between gout and osteoporosis is poorly clarified, and the association between gout and fractures incidence remains...
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The Effects of Pharmacological Urate-Lowering Therapy on Cardiovascular Disease in Older Adults with Gout
Cardiovascular disease is an important cause of mortality in older patients. In addition to the traditional risk factors for cardiovascular disease,...
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Epidemiology and diagnosis of gout in sub-saharan Africa: a sco** review
BackgroundThe episodic nature of gout and diagnostic uncertainty in the absence of microcrystal evidence make it particularly difficult to estimate...
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Cohort study investigating gout flares and management in UK general practice
BackgroundGout is the most common inflammatory arthritis and is almost exclusively managed in primary care, however the course and severity of the...
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Alterations in lipidome profiles distinguish early-onset hyperuricemia, gout, and the effect of urate-lowering treatment
BackgroundCurrently, it is not possible to predict whether patients with hyperuricemia (HUA) will develop gout and how this progression may be...
