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Effect of goal-directed haemodynamic therapy guided by non-invasive monitoring on perioperative complications in elderly hip fracture patients within an enhanced recovery pathway
BackgroundGoal-directed haemodynamic therapy (GDHT) has been shown to reduce morbidity and mortality in high-risk surgical patients. However, there...
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OCOSO2: study protocol for a single-blinded, multicentre, randomised controlled trial assessing a central venous oxygen saturation-based goal-directed therapy to reduce postoperative complications in high-risk patients after elective major surgery
BackgroundFluid loading-based goal-directed therapy is a cornerstone of anaesthesia management in major surgery. Its widespread application has...
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Hypotension Prediction Index guided Goal Directed therapy and the amount of Hypotension during Major Gynaecologic Oncologic Surgery: a Randomized Controlled clinical Trial
Intraoperative hypotension (IOH) is associated with increased morbidity and mortality. Hypotension Prediction Index (HPI) is a machine learning...
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Haemodynamic monitoring during noncardiac surgery: past, present, and future
During surgery, various haemodynamic variables are monitored and optimised to maintain organ perfusion pressure and oxygen delivery – and to...
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Goal-directed haemodynamic therapy (GDHT) in surgical patients: systematic review and meta-analysis of the impact of GDHT on post-operative pulmonary complications
BackgroundPerioperative goal-directed haemodynamic therapy (GDHT), defined as the administration of fluids with or without inotropes or vasoactive...
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Patient phenotype profiling using echocardiography and natriuretic peptides to personalise heart failure therapy
Heart failure (HF) is a progressive condition with a clinical picture resulting from reduced cardiac output (CO) and/or elevated left ventricular...
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Perioperative advanced haemodynamic monitoring of patients undergoing multivisceral debulking surgery: an observational pilot study
BackgroundPatients undergoing high-risk surgery show haemodynamic instability and an increased risk of morbidity. However, most of the available data...
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Early Goal-Directed Therapy With and Without Intermittent Superior Vena Cava Oxygen Saturation Monitoring in Pediatric Septic Shock: A Randomized Controlled Trial
ObjectiveTo compare early goal-directed therapy (EGDT) ‘with’ and ‘without’ intermittent superior vena cava oxygen saturation (ScvO 2 ) monitoring in...
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Intraoperative pleth variability index-based fluid management therapy and gastrointestinal surgical outcomes in elderly patients: a randomised controlled trial
BackgroundIntraoperative goal-directed fluid therapy (GDFT) has been reported to reduce postoperative complications of patients undergoing major...
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Fluid challenge in critically ill patients receiving haemodynamic monitoring: a systematic review and comparison of two decades
IntroductionFluid challenges are widely adopted in critically ill patients to reverse haemodynamic instability. We reviewed the literature to...
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A comparison of intraoperative goal-directed intravenous administration of crystalloid versus colloid solutions on the postoperative maximum N-terminal pro brain natriuretic peptide in patients undergoing moderate- to high-risk noncardiac surgery
BackgroundN-terminal pro brain natriuretic peptide (NT-proBNP) and troponin T are released during myocardial wall stress and/or ischemia and are...
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Perioperative changes in fluid distribution and haemodynamics in acute high-risk abdominal surgery
BackgroundUnderstanding the pathophysiology of fluid distribution in acute high-risk abdominal (AHA) surgery is essential in optimizing fluid...
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Standardised Critical Care Strategies Improve Outcomes Following Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy in an Indian Peritoneal Malignancy Centre
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is a major undertaking with profound peri-operative metabolic and...
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Twenty percent human albumin solution fluid bolus administration therapy in patients after cardiac surgery-II: a multicentre randomised controlled trial
PurposeAfter cardiac surgery, fluid bolus therapy (FBT) with 20% human albumin may facilitate less fluid and vasopressor administration than FBT with...
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Observational study on fluid therapy management in surgical adult patients
BackgroundPerioperative fluid therapy management is changing due to the incorporation of different fluids, surgical techniques, and minimally...
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Interplay of hypoxia-inducible factors and oxygen therapy in cardiovascular medicine
Mammals have evolved to adapt to differences in oxygen availability. Although systemic oxygen homeostasis relies on respiratory and circulatory...
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Diagnosis, pathophysiology and preventive strategies for cardiac surgery-associated acute kidney injury: a narrative review
Acute kidney injury (AKI) is a common and serious complication of cardiac surgery and is associated with increased mortality and morbidity,...
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Pharmacokinetic Alterations Associated with Critical Illness
Haemodynamic, metabolic, and biochemical derangements in critically ill patients affect drug pharmacokinetics and pharmacodynamics making dose...
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Active cycle of breathing technique versus oscillating PEP therapy versus walking with huffing during an acute exacerbation of bronchiectasis: a randomised, controlled trial protocol
BackgroundAirway clearance techniques (ACTs) for individuals with bronchiectasis are routinely prescribed in clinical practice and recommended by...
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Comparison of anaesthesia strategies on postoperative nausea and vomiting in laparoscopic sleeve gastrectomy: a randomised controlled trial
BackgroundIntra-operative anaesthesia management should be optimised to reduce the occurrence of postoperative nausea and vomiting in high-risk...
