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Beneficial effects of time and energy restriction diets on the development of experimental acute kidney injury in Rat: Bax/Bcl-2 and histopathological evaluation
People’s lifestyles and, especially, their eating habits affect their health and the functioning of the organs in their bodies, including the...
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Regulation of FGF23 production and phosphate metabolism by bone–kidney interactions
The bone-derived hormone fibroblast growth factor 23 (FGF23) functions in concert with parathyroid hormone (PTH) and the active vitamin D metabolite,...
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Effect of bovine milk fat-based infant formulae on microbiota, metabolites and stool parameters in healthy term infants in a randomized, crossover, placebo-controlled trial
BackgroundNatural enrichment of sn-2 palmitate content of infant formulae by using bovine milk fat is known to reduce formation of faecal fatty acid...
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Utilising Endogenous Biomarkers in Drug Development to Streamline the Assessment of Drug–Drug Interactions Mediated by Renal Transporters: A Pharmaceutical Industry Perspective
The renal secretion of many drugs is facilitated by membrane transporters, including organic cation transporter 2, multidrug and toxin extrusion...
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SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study
BackgroundSodium-glucose cotransporter 2 (SGLT2) and SGLT1 inhibitors may have additional beneficial metabolic effects on circulating metabolites...
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Blood pressure and kidney function in neonates and young infants with intrauterine growth restriction
BackgroundIntrauterine growth restriction (IUGR) has been associated with changes in kidney anatomy, nephrogenesis and the vascular system, resulting...
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Cardioprotection by selective SGLT-2 inhibitors in a non-diabetic mouse model of myocardial ischemia/reperfusion injury: a class or a drug effect?
Major clinical trials with sodium glucose co-transporter-2 inhibitors (SGLT-2i) exhibit protective effects against heart failure events, whereas...
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Ammonia Removal by Metabolic Scavengers for the Prevention and Treatment of Hepatic Encephalopathy in Cirrhosis
Effective lowering of circulating ammonia is the mainstay strategy in the prevention and treatment of hepatic encephalopathy in cirrhosis and there...
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Nonspecific protection of heat-inactivated Mycobacterium bovis against Salmonella Choleraesuis infection in pigs
Trained immunity is the capacity of innate immune cells to produce an improved response against a secondary infection after a previous unrelated...
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The role of fibroblast growth factor 23 in regulation of phosphate balance
Phosphate is essential for numerous biological processes, and serum levels are tightly regulated to accomplish these functions. The regulation of...
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Chemical composition and antifungal activity of Teucrium Leucocladum Boiss. essential oils growing in Egypt using two different techniques
BackgroundTeucrium Leucocladum Boiss. (TL) (family Lamiaceae), indigenous to Sinai, Egypt, and Mediterranean region, is considered a rich source of...
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Huangqi decoction ameliorates kidney injury in db/db mice by regulating the BMP/Smad signaling pathway
PurposeThis study aims to investigate the mechanism underlying the beneficial effects of Huangqi decoction (HQD) on Diabetic kidney disease (DKD) in...
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Changes in the gut bacteriome upon gluten-free diet intervention do not mediate beta cell preservation
Aims/hypothesisWe previously detected indications that beta cell function is protected by gluten-free diet (GFD) introduced shortly after the onset...
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Long-term health outcomes associated with hydration status
Body water balance is determined by fundamental homeostatic mechanisms that maintain stable volume, osmolality and the composition of extracellular...
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Exposures of Phenylacetic Acid and Phenylacetylglutamine Across Different Subpopulations and Correlation with Adverse Events
BackgroundElevated plasma ammonia is central to the pathogenesis of hepatic encephalopathy. Sodium phenylacetate or glycerol phenylbutyrate is...
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Gutted: constipation in children with chronic kidney disease and on dialysis
Functional constipation is a common problem in otherwise healthy children. Children with chronic kidney disease (CKD) and on dialysis have additional...
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Urinary markers of Mycobacterium tuberculosis and dysbiosis in paediatric tuberculous meningitis cases undergoing treatment
BackgroundThe pathogenesis of tuberculous meningitis (TBM) involves infection by Mycobacterium tuberculosis in the meninges and brain. However,...
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New insights and potential biomarkers for intraventricular hemorrhage in extremely premature infant, case-control study
BackgroundDespite advancements in neonatal care, germinal matrix-intraventricular hemorrhage impacts 20% of very preterm infants, exacerbating their...
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Population Pharmacokinetic Analysis to Assist Dose Selection of the l-Ornithine Salt of Phenylacetic Acid
Background and Objectivel -Ornithine phenylacetate is an intravenous formulation of the l -ornithine salt of phenylacetic acid under development for...
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Analysis of the relationship of refractory gout between potential biomarkers and diet structure and lifestyle based on 1H-NMR
ObjectiveWe investigated the different life styles among the diet structures and exercise patterns of 100 patients with refractory gout and 79...
