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D-mannose alleviates intervertebral disc degeneration through glutamine metabolism
BackgroundIntervertebral disc degeneration (IVDD) is a multifaceted condition characterized by heterogeneity, wherein the balance between catabolism...
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Targeting glutamine metabolism exhibits anti-tumor effects in thyroid cancer
BackgroundEffective treatment for patients with advanced thyroid cancer is lacking. Metabolism reprogramming is required for cancer to undergo...
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A Population Pharmacokinetic Analysis of l-Glutamine Exposure in Patients with Sickle Cell Disease: Evaluation of Dose and Food Effects
Background and Objectivel -Glutamine is a treatment for children and adults with sickle cell disease. A comprehensive evaluation of the...
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Glutamine is a substrate for glycosylation and CA19-9 biosynthesis through hexosamine biosynthetic pathway in pancreatic cancer
BackgroundCarbohydrate antigen 19–9 (CA19-9) is the most widely used biomarker for pancreatic cancer. Since CA19-9 closely correlates with patient...
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Targeting Glutamine Metabolism as an Attractive Therapeutic Strategy for Acute Myeloid Leukemia
Relapse after chemotherapy and hematopoietic stem cell transplantation leads to adverse prognosis for acute myeloid leukemia (AML) patients. As a...
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SLC38A5 promotes glutamine metabolism and inhibits cisplatin chemosensitivity in breast cancer
BackgroundSolute carrier family 38 member 5 (SLC38A5), as an amino acid transporter, play a vital role in cellular biological processes. In this...
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YAP governs cellular adaptation to perturbation of glutamine metabolism by regulating ATF4-mediated stress response
Proliferating cells have metabolic dependence on glutamine to fuel anabolic pathways and to refill the mitochondrial carbon pool. The Hippo pathway...
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Magnetic resonance spectroscopy in MELAS syndrome: correlation with CSF and plasma metabolite levels and change after glutamine supplementation
PurposeMELAS syndrome is a genetic disorder caused by mitochondrial DNA mutations. We previously described that MELAS patients had increased CSF...
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Glutamine stabilizes myc via alpha-ketoglutarate and regulates paclitaxel sensitivity
Metabolic reprogramming wherein the cancer cells exhibit altered energetics is a hallmark of cancer. Although recent discoveries have enhanced our...
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Glutamine addiction promotes glucose oxidation in triple-negative breast cancer
Glutamine is a conditionally essential nutrient for many cancer cells, but it remains unclear how consuming glutamine in excess of growth...
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Glutamine induces remodeling of tight junctions in Caco-2 colorectal cancer cell
Malignant cells often exhibit significant metabolic alterations, including the utilization of different nutrients to meet energetic and biosynthetic...
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RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis
Cellular senescence provides a protective barrier against tumorigenesis in precancerous or normal tissues upon distinct stressors. However, the...
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Cancer-associated fibroblast-specific lncRNA LINC01614 enhances glutamine uptake in lung adenocarcinoma
BackgroundBesides featured glucose consumption, recent studies reveal that cancer cells might prefer “addicting” specific energy substrates from the...
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Effects of glutamine on plasma protein and inflammation in postoperative patients with colorectal cancer: a meta-analysis of randomized controlled trials
ObjectiveTo evaluate the effects of glutamine on the plasma protein and inflammatory responses in colorectal cancer (CRC) patients following radical...
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L-glutamine for sickle cell disease: more than reducing redox
Oxidative stress is a major contributor to the pathophysiology of sickle cell disease (SCD) including hemolysis and vaso-occlusive crisis (VOC)....
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Antitumor activity of mianserin (a tetracyclic antidepressant) primarily driven by the inhibition of SLC1A5-mediated glutamine transport
Targeting tumor metabolic vulnerabilities such as “glutamine addiction” has become an attractive approach for the discovery of novel antitumor...
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Integrative analysis reveals that SLC38A1 promotes hepatocellular carcinoma development via PI3K/AKT/mTOR signaling via glutamine mediated energy metabolism
Although hepatocellular carcinoma (HCC) is rather frequent, little is known about the molecular pathways underlying its development, progression, and...
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Ammonia scavenger and glutamine synthetase inhibitors cocktail in targeting mTOR/β-catenin and MMP-14 for nitrogen homeostasis and liver cancer
The glutamine synthetase (GS) facilitates cancer cell growth by catalyzing de novo glutamine synthesis. This enzyme removes ammonia waste from the...
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Immunological effects of glutamine supplementation in polytrauma patients in intensive care unit
BackgroundIn polytrauma intensive care unit (ICU) patients, glutamine (GLN) becomes a “conditionally essential” amino acid; its role has been...
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Targeting glutamine metabolism network for the treatment of therapy-resistant prostate cancer
Advanced and aggressive prostate cancer (PCa) depends on glutamine for survival and proliferation. We have previously shown that inhibition of...
