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Are anti-glutamic acid decarboxylase 65-kDa isoform antibodies related to diabetes or brain tumor?
BackgroundAntibodies against the 65-kDa isoform of glutamic acid decarboxylase (GAD65) are biomarkers of autoimmune disorders and are more common in...
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Supplementation of High-Strength Oral Probiotics Improves Immune Regulation and Preserves Beta Cells among Children with New-Onset Type 1 Diabetes Mellitus: A Randomised, Double-Blind Placebo Control Trial
ObjectivesTo investigate the mechanism of glycemic control in children with type 1 diabetes (T1D) following high-strength probiotics supplementation...
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Cerebral glucose hypometabolism and hypoperfusion of cingulate gyrus: an imaging biomarker of autoimmune encephalitis with psychiatric symptoms
BackgroundAbout 60% of autoimmune encephalitis (AE) patients present psychiatric symptoms, but the underlying mechanism remains unknown. This study...
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Diagnosis of latent autoimmune diabetes after SARS–Cov2 vaccination in adult patients previously diagnosed with type 2 diabetes mellitus
ObjectiveAcute worsening of glycemic control in diabetic patients and new–onset type I diabetes were reported after severe acute respiratory syndrome...
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Prevalence of Positivity for Diabetes-Associated Autoantibodies in Individuals with Type 2 Diabetes and Their Further Characterisation: Cross-sectional Study from Slovakia
BackgroundIndividuals initially diagnosed with type 2 diabetes (T2D) might exhibit positivity for diabetes-associated autoantibodies (DAA +). We...
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Impairment of the GABAergic system in the anterior insular cortex of heroin-addicted males
Opioid addiction is a global problem, causing the greatest health burden among drug use disorders, with opioid overdose deaths top** the statistics...
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Immune checkpoint inhibitor induced anti-glutamic acid decarboxylase 65 (Anti-GAD 65) limbic encephalitis responsive to intravenous immunoglobulin and plasma exchange
Immune checkpoint inhibitors have made significant advances in available cancer treatment options towards progression-free and overall survival in...
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Inverse pattern of GABAergic system impairment in the external versus internal globus pallidus in male heroin addicts
Opioid addiction is a global problem that has been exacerbated in the USA and Europe by the COVID-19 pandemic. The globus pallidus (GP) plays a...
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Assessment of anti-GAD65-associated cerebellar ataxia with 18F-FDG cerebellar uptake: ROC analysis
ObjectiveAnti-glutamic acid decarboxylase 65 (anti-GAD65)-associated neurological disorders include two major phenotypes, namely Stiff person...
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Plasma metabolomic profile in orthostatic intolerance children with high levels of plasma homocysteine
BackgroundOrthostatic intolerance, which includes vasovagal syncope and postural orthostatic tachycardia syndrome, is common in children and...
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RETRACTED ARTICLE: Hydralazine Promotes Central Nervous System Recovery after Spinal Cord Injury by Suppressing Oxidative Stress and Inflammation through Macrophage Regulation
ObjectiveThis study aims to investigate the effects of hydralazine on inflammation induced by spinal cord injury (SCI) in the central nervous system...
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Amino acid metabolism in health and disease
Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth,...
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The Current Role of Valproic Acid in the Treatment of Epilepsy: A Glimpse into the Present of an Old Ally
Purpose of the reviewThe primary purpose of this review is to explore the specific clinical scenarios where valproic acid demonstrates superiority...
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Characterization of newly diagnosed type 1 diabetes in children and adolescents from 2017 to 2022 in China: a single-center analysis
ObjectiveThis study investigated the characteristics of newly diagnosed type 1 diabetes mellitus (T1DM) related to autoimmunity and the frequency of...
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Distinct changes to pancreatic volume rather than pancreatic autoantibody positivity: insights into immune checkpoint inhibitors induced diabetes mellitus
BackgroundImmune checkpoint inhibitors (ICI) are promising treatment options for various cancers. However, their use is associated with...
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The relationship between GAD65 autoantibody and the risk of T1DM onset
ObjectivesType 1 diabetes mellitus (T1DM) is a well-known autoimmune disease, characterized by β-cell destruction in pancreas islet cells, which...
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Acid resistance system CadBA is implicated in acid tolerance and biofilm formation and is identified as a new virulence factor of Edwardsiella tarda
Edwardsiella tarda is a facultative intracellular pathogen in humans and animals. The Gram-negative bacterium is widely considered a potentially...
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Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy
Amino acids are basic nutrients for immune cells during organ development, tissue homeostasis, and the immune response. Regarding metabolic...
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From lab bench to hope: a review of gene therapies in clinical trials for Parkinson’s disease and challenges
Parkinson's disease (PD) is a chronic neurological disorder that is identified by a characteristic combination of symptoms such as bradykinesia,...
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The association of islet autoantibodies with the neural retinal thickness and microcirculation in type 1 diabetes mellitus with no clinical evidence of diabetic retinopathy
ObjectiveTo examine the association between islet autoantibodies (IAbs) and the retinal neurovascular changes in type 1 diabetes mellitus (T1DM) with...
