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Characteristics of peripheral blood mononuclear cells and potential related molecular mechanisms in patients with autoimmune hepatitis: a single-cell RNA sequencing analysis
Autoimmune hepatitis (AIH) is an immune disorder characterized by hypergammaglobulinemia, autoantibodies, and chronic active hepatitis on liver...
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A comprehensive review on immune checkpoint inhibitors induced cardiotoxicity characteristics and associated factors
Newly approved cancer drugs called ICIs have shown remarkable success in improving patient survival rates, but they also have the potential for...
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Hypopituitarism and pregnancy: clinical characteristics, management and pregnancy outcome
PurposeTo describe the clinical characteristics, management and pregnancy outcome of women with prepregnancy hypopituitarism (HYPO) that received...
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mTOR pathway gene expression in association with race and clinicopathological characteristics in Black and White breast cancer patients
BackgroundAberrant activation of the mammalian Target of Rapamycin (mTOR) pathway has been linked to obesity and endocrine therapy resistance,...
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IRF8 and its related molecules as potential diagnostic biomarkers or therapeutic candidates and immune cell infiltration characteristics in steroid-induced osteonecrosis of the femoral head
PurposeSteroid-induced osteonecrosis of the femoral head (SONFH) was a refractory orthopedic hip joint disease in the young and middle-aged people,...
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Clinicopathological characteristics and associated factors of idiopathic membranous nephropathy with hyperuricemia: a single-centered cross-sectional study
PurposeThis study was designed to investigate the clinicopathological features of idiopathic membranous nephropathy (IMN) with hyperuricemia (HUA),...
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Dry Eye Disease Associated with Meibomian Gland Dysfunction: Focus on Tear Film Characteristics and the Therapeutic Landscape
Meibomian gland dysfunction (MGD) is highly prevalent and is the leading cause of evaporative dry eye disease (DED). MGD is characterized by a...
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An Overview of Osteoporosis and Possible Treatment Approaches
Osteoporosis is most prevalent in postmenopausal women and is a widespread condition that impacts millions of individuals worldwide. A decrease in...
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Mild autonomous cortisol secretion: pathophysiology, comorbidities and management approaches
The majority of incidentally discovered adrenal tumours are benign adrenocortical adenomas and the prevalence of adrenocortical adenomas is around...
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The role of pro-opiomelanocortin in the ACTH–cortisol dissociation of sepsis
BackgroundSepsis is typically hallmarked by high plasma (free) cortisol and suppressed cortisol breakdown, while plasma adrenocorticotropic hormone...
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Orbital inflammatory pseudotumor: new advances in diagnosis, pathogenesis, and treatment
Orbital inflammatory pseudotumor (OIP) is a benign, non-specific inflammatory disorder that commonly occurs in middle-aged adults and is usually...
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The glucocorticoid receptor gene (NR3C1) is linked to and associated with polycystic ovarian syndrome in Italian families
ObjectivesComponents of the hypothalamic-pituitary axis (HPA) pathway are potential mediators of the genetic risk of polycystic ovarian syndrome...
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Characteristics of adrenal insufficiency in hemodialysis patients
BackgroundAdrenal insufficiency causes abnormal subjective symptoms such as general fatigue, signs such as hypotension, and abnormalities such as...
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Predictive value of C-X-C motif chemokine receptor 4-directed molecular imaging in patients with advanced adrenocortical carcinoma
BackgroundIn patients affected with adrenocortical carcinoma (ACC), C-X-C motif chemokine receptor 4 (CXCR4) is highly expressed in sites of disease...
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Low dose of dexamethasone combined with netupitant and palonosetron in preventing nausea and vomiting in breast cancer patients induced by anthracycline drugs
BackgroundTo study the effects of various courses of dexamethasone (DEX) combined with 5-HT3 receptor antagonists (RA) and NK-1 RA in suppressing...
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Osteoporotic vertebral compression fractures caused by Cushing’s syndrome in young women: case report and literature review
BackgroundCushing’s syndrome is known as an important cause of secondary osteoporosis, characterized by reduction of bone mineral density and...
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Mavorixafor: First Approval
Mavorixafor (XOLREMDI™) is an oral, selective C-X-C chemokine receptor 4 (CXCR4) antagonist developed by X4 Pharmaceuticals that blocks the binding...
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Podocyte-targeted therapies — progress and future directions
Podocytes are the key target cells for injury across the spectrum of primary and secondary proteinuric kidney disorders, which account for up to 90%...
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11-beta-hydroxysteroid dehydrogenase type 1 (HSD11B1) gene expression in muscle is linked to reduced skeletal muscle index in sarcopenic patients
BackgroundGlucocorticoids play a significant role in metabolic processes and pathways that impact muscle size, mass, and function. The expression of...
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Impact of baseline clinical asthma characteristics on the response to mepolizumab: a post hoc meta-analysis of two Phase III trials
BackgroundSevere asthma is associated with a broad range of phenotypes and clinical characteristics. This analysis assessed whether select baseline...
