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Myeloperoxidase immunohistochemical staining can identify glomerular endothelial cell injury in dense deposit disease
BackgroundPrevious studies have demonstrated residual complement-mediated deposits in repeat kidney biopsies of C3 glomerulopathies (C3G) (dense...
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TRIM27 contributes to glomerular endothelial cell injury in lupus nephritis by mediating the FoxO1 signaling pathway
Tripartite motif-containing 27 (TRIM27) belongs to the triple motif (TRIM) protein family, which plays a role in a variety of biological activities....
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Endothelial-derived complement factor D contributes to endothelial dysfunction in malignant nephrosclerosis via local complement activation
Malignant nephrosclerosis is a thrombotic microangiopathy associated with abnormal local activation of the complement alternative pathway (AP)....
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Vascular endothelial cell development and diversity
Vascular endothelial cells form the inner layer of blood vessels where they have a key role in the development and maintenance of the functional...
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Glomerular injury after trauma, burn, and sepsis
Acute kidney injury development after trauma, burn, or sepsis occurs frequently but remains a scientific and clinical challenge. Whereas the...
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B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis
Hyperhomocysteinemia (HHcy) is a risk factor for chronic kidney diseases (CKDs) that affects about 85% CKD patients. HHcy stimulates B cells to...
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Total flavonoids of Astragalus protects glomerular filtration barrier in diabetic kidney disease
BackgroundDiabetic kidney disease (DKD) is a prevalent complication of diabetes and the leading cause of end-stage renal disease. Recent evidence...
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Prognostic role of glomerular electron microscopy lesions in IgA nephropathy: “the devil is in the details”
IntroductionTransmission electron microscopy enables examination of ultrastructural glomerular changes; while this tool has already been applied in...
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Role of abnormal glycosylated IgA1 and interstitial transformation of glomerular endothelial cells in the development and progression of IgA nephropathy
BackgroundIgA nephropathy (IgAN) is a common primary renal disease in childhood.
MethodsTwenty blood samples and renal tissue from patients with...
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Activation of mTOR mediates hyperglycemia-induced renal glomerular endothelial hyperpermeability via the RhoA/ROCK/pMLC signaling pathway
ObjectiveHyperglycemia is associated with albuminuria and renal glomerular endothelial dysfunction in patients with diabetic nephropathy. The mTOR...
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The Mesangial cell — the glomerular stromal cell
Mesangial cells are stromal cells that are important for kidney glomerular homeostasis and the glomerular response to injury. A growing body of...
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Glomerular expression and urinary excretion of fatty acid-binding protein 4 in IgA nephropathy
BackgroundFatty acid-binding protein 4 (FABP4) is secreted from adipocytes and macrophages in adipose tissue and acts as an adipokine. It has...
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Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes
BackgroundDiabetes mellitus is a chronic disease which is detrimental to cardiovascular health, often leading to secondary microvascular...
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Caveolin-1 in situ expression in glomerular and peritubular capillaries as a marker of ultrastructural progression and severity of renal thrombotic microangiopathy
BackgroundThrombotic microangiopathy is a severe and potentially life-threatening condition inducing severe endothelial injury in many organs,...
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Underlying Mechanisms and Treatment of Hypertension in Glomerular Diseases
Purpose of ReviewThis review aims to explore the underlying mechanisms that lead to hypertension in glomerular diseases and the advancements in...
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Renal microvascular endothelial cell responses in sepsis-induced acute kidney injury
Microvascular endothelial cells in the kidney have been a neglected cell type in sepsis-induced acute kidney injury (sepsis-AKI) research; yet, they...
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Nivolumab-associated glomerular endothelial injury in a patient with gastric cancer
A 68-year-old male with gastric cancer was treated with tegafur/gimeracil/oteracil and oxaliplatin for 6 months. Thereafter, he was treated with...
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Estimated glomerular filtration rate in Brazilian adults with sickle cell disease: results from the REDS-III multicenter cohort study
Chronic kidney disease (CKD) has a significant impact on sickle cell disease (SCD) morbidity and mortality. Early identification of individuals at...
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A case of proliferative glomerulonephritis with monoclonal IgG3κ deposits accompanied by glomerular capillary microaneurysms
Glomerular capillary aneurysms are distinctly rare and specific glomerular lesions characterized by aneurysmal dilatation of the glomerular...
