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Histogenesis of intracranial germ cell tumors: primordial germ cell vs. embryonic stem cell
IntroductionIntracranial germ cell tumor (iGCT) is a rare disorder and often occurs during childhood and adolescence. iGCTs are frequently localized...
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Ovarian Germ Cell Tumors in North-Western India: A Comprehensive 3-Year Retrospective Study of 145 Cases at a Tertiary Cancer Hospital
Germ cell tumors encompass a broad spectrum of neoplasms arising from germ cell lineage, demonstrating varying histological profiles and clinical...
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Translation research on testicular germ cell tumors
Testicular germ cell tumors are the most common malignancy in men aged 14 to 44 years. Although exceptional cisplatin sensitivity results in cure...
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Simultaneous Bilateral Yolk Sac Tumors: A Rare Presentation of Mixed Germ Cell Tumors
BackgroundYolk sac tumors are rare ovarian malignancies accounting for less than 1% of malignant ovarian germ cell tumors. They are mostly seen in...
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Unusual imaging findings associated with abdominal pediatric germ cell tumors
Germ cell tumors of childhood are tumors arising from germline cells in gonadal or extragonadal locations. Extragonadal germ cell tumors are...
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Germ Cell Tumour in Male and Female Siblings: A Case Report and Literature Review
IntroductionGerm cell tumours account for about 2–3% of childhood malignancies. Germ cell tumour in siblings are rare, and particularly male and...
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Germ cell tumors with neuroglial differentiation do not show molecular features akin to their central nervous system counterpart: experience from extra-gynecological sites
Teratomas with secondary somatic malignancy showing neuroglial differentiation (central nervous system (CNS)-type tumors) arising from a glial or...
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Familial syndromes associated with testicular and paratesticular neoplasms: a comprehensive review
A syndromic association between a subset of testicular/paratesticular neoplasms is well established. Such examples include Carney complex and large...
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Spectrum of Germ Cell Tumor (GCT): 5 Years’ Experience in a Tertiary Care Center and Utility of OCT4 as a Diagnostic Adjunct
Germ cell tumors (GCT) are an intriguing group of neoplasm having myriad clinical and morphological presentation. More and more transcription factors...
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Molecular characterization of the CXCR4 / CXCR7 axis in germ cell tumors and its targetability using nanobody-drug-conjugates
Being stimulated by the chemokine CXCL12, the CXCR4 / CXCR7 cascade is involved in tumor proliferation, migration, and metastasis. The interaction...
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SEOM-GG clinical guidelines for the management of germ-cell testicular cancer (2023)
Testicular germ cell tumors are the most common tumors in adolescent and young men. They are curable malignancies that should be treated with...
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Non-invasive differential diagnosis of teratomas from other intracranial germ cell tumours using MRI-based fractal and radiomic analyses
ObjectivesThe histologic subtype of intracranial germ cell tumours (IGCTs) is an important factor in deciding the treatment strategy, especially for...
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Atypical cartilage in type II germ cell tumors of the mediastinum show significantly different patterns of IDH1/2 mutations from conventional chondrosarcoma
Neoplastic cartilage is a common component of teratomas in type II germ cell tumors. Although IDH1/2 mutations have been well-described in somatic...
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How to classify, diagnose, treat and follow-up extragonadal germ cell tumors? A systematic review of available evidence
PurposeTo present the current evidence and the development of studies in recent years on the management of extragonadal germ cell tumors (EGCT).
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Histopathology and prognosis of germ cell tumors metastatic to brain: cohort study
IntroductionGerm cell tumors (GCTs) are uncommon neoplasms predominantly arising in midline tissues. The prognostic significance of histopathology in...
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Proteomic profiling of cisplatin-resistant and cisplatin-sensitive germ cell tumour cell lines using quantitative mass spectrometry
PurposeAdvanced testicular germ cell tumours (GCT) generally have a good prognosis owing to their unique sensitivity towards cisplatin-based...
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Molecular correlates of male germ cell tumors with overgrowth of components resembling somatic malignancies
A small subset of male germ cell tumors (GCT) demonstrates overgrowth of histologic components that resemble somatic malignancies (e.g., sarcoma,...
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Impact of tumor markers on diagnosis, treatment and prognosis in CNS germ cell tumors: correlations with clinical practice and histopathology
Tumor markers in CNS germ cell tumors (GCTs) include human chorionic gonadotropin (HCG) and alpha fetoprotein (AFP), which have significant...
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A rare case of ovarian gonadoblastoma flourishing into malignant mixed germ cell tumour with review of literature
Gonadoblastoma is an extremely rare neoplasm of the ovary showing admixture of germ cells and sex cord cells. It may be associated with gonadal...
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Outcomes of intracranial non-germinomatous germ cell tumors: a retrospective Asian multinational study on treatment strategies and prognostic factors
PurposeNon-germinomatous germ cell tumors (NGGCTs) are rare pediatric conditions. This multicenter study using Asian multinational patient data...
