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A Brief Review of Gepants
Purpose of ReviewGepants are small molecules that antagonize calcitonin gene-related peptide (CGRP) receptors. Due to their favorable side effect...
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Update of Gepants in the Treatment of Chronic Migraine
Purpose of ReviewDespite the unmet therapeutic needs of patients with chronic migraine (CM) and/or medication overuse, available treatment options...
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Safety and Tolerability of Combining CGRP Monoclonal Antibodies with Gepants in Patients with Migraine: A Retrospective Study
IntroductionThe introduction of clacitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) has revolutionized the treatment of migraines. In...
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Gepants — a long way to cure: a narrative review
Calcitonin gene-related peptide (CGRP) is probably the most potent vasodilator in cerebral circulation. Forty years after its discovery, the new...
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What to do with non-responders to CGRP(r) monoclonal antibodies: switch to another or move to gepants?
In this editorial we aim to provide potential therapeutic options in patients who do not benefit from treatment with CGRP(r) monoclonal antibodies....
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The comparative effectiveness of migraine preventive drugs: a systematic review and network meta-analysis
ObjectiveWhile there are several trials that support the efficacy of various drugs for migraine prophylaxis against placebo, there is limited...
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Mode and site of action of therapies targeting CGRP signaling
Targeting CGRP has proved to be efficacious, tolerable, and safe to treat migraine; however, many patients with migraine do not benefit from drugs...
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The Role of Step Therapy in the Treatment of Migraine
Purpose of ReviewThis review examines recent evidence and applies bioethical principles to evaluate the benefits and risks of using step therapy in...
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Is the right way to go in between?
In the study by Johnston et al., gepants were meant to be taken to treat emergent migraine. It is tempting to speculate what the effect would be if...
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Cardiovascular Disease and Migraine: Are the New Treatments Safe?
Purpose of ReviewThe authors present data on cardiovascular safety for the new acute and preventive migraine treatments including ditans, gepants,...
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CGRP-targeted medication in chronic migraine - systematic review
BackgroundChronic migraine is a highly debilitating condition that is often difficult to manage, particularly in the presence of medication overuse...
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Migraine: from pathophysiology to treatment
Migraine is an extremely disabling, common neurological disorder characterized by a complex neurobiology, involving a series of central and...
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Unmet Needs in the Acute Treatment of Migraine
Migraine represents the most common neurologic disorder, ranking second among the world’s causes of disability [expressed as years lived with...
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Acute Treatment of Migraine: Expert Consensus Statements from the United Arab Emirates (UAE)
IntroductionMigraine, characterized by recurrent headaches and often accompanied by other symptoms like nausea, vomiting, and sensitivity to light...
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Outpatient Approach to Resistant and Refractory Migraine in Children and Adolescents: a Narrative Review
Purpose of ReviewMigraine is one of the top reasons for consulting a pediatric neurologist. Although the majority of children and adolescents who...
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Drug Safety in Episodic Migraine Management in Adults Part 1: Acute Treatments
Purpose of ReviewThe aim of this review is to aid in choosing safe options when assessing potential risks of acute migraine treatments based on known...
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A Review of Calcitonin Gene-Related Peptide and Its Implications for Vestibular Disorders
Purpose of reviewCalcitonin gene-related peptide (CGRP) is an inflammatory neuropeptide widely present throughout the body and involved in many...
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Ten open questions in migraine prophylaxis with monoclonal antibodies blocking the calcitonin-gene related peptide pathway: a narrative review
The monoclonal antibodies (mAbs) blocking the calcitonin-gene related peptide (CGRP) pathway, collectively called here “anti-CGRP/rec mAbs”, have...
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Drug Safety in Episodic Migraine Management in Adults. Part 2: Preventive Treatments
Purpose of ReviewThe aim of this review is to aid in decision-making when choosing safe and effective options for preventive migraine medications.
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Migraine
Migraine is a common, chronic, disorder that is typically characterized by recurrent disabling attacks of headache and accompanying symptoms,...
