Search
Search Results
-
Identifying novel proteins for suicide attempt by integrating proteomes from brain and blood with genome-wide association data
Genome-wide association studies (GWASs) have identified risk loci for suicide attempt (SA), but deciphering how they confer risk for SA remains...
-
A genome-wide association study of survival in patients with sepsis
BackgroundSepsis is a severe systemic inflammatory response to infections that is accompanied by organ dysfunction and has a high mortality rate in...
-
A genetic correlation scan identifies blood proteins associated with bone mineral density
BackgroundOsteoporosis is a common metabolic bone disease that is characterized by low bone mass. However, limited efforts have been made to explore...
-
Comparison of the loci associated with HbA1c and blood glucose levels identified by a genome-wide association study in the Japanese population
AimsHemoglobin A1c (HbA1c) levels are widely employed to diagnose diabetes. However, estimates of the heritability of HbA1c and glucose levels are...
-
Prioritizing drug targets in systemic lupus erythematosus from a genetic perspective: a druggable genome-wide Mendelian randomization study
ObjectivesSystemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with an unsatisfactory state of treatment. We aim to explore novel...
-
A genome-wide scan for pleiotropy between bone mineral density and nonbone phenotypes
Osteoporosis is the most common metabolic bone disorder globally and is characterized by skeletal fragility and microarchitectural deterioration....
-
Identification of carrier status of Xp22.31 microdeletions associated with X-linked ichthyosis at the single-cell level using haplotype linkage analysis by karyomap**
PurposeCurrently, owing to the limitations of high-throughput sequencing depth and the allele dropout caused by the whole-genome amplification,...
-
IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis
BackgroundCombination antiretroviral treatment (cART) cannot eradicate HIV-1 from the body due to the establishment of persisting viral reservoirs...
-
Genome-wide map** of brain phenotypes in extended pedigrees with strong genetic loading for bipolar disorder
Bipolar disorder is a highly heritable illness, associated with alterations of brain structure. As such, identification of genes influencing...
-
Genome-wide association study of Alzheimer’s disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and the most common form of dementia in the elderly. Susceptibility to AD...
-
Genome-wide linkage scan for loci influencing plasma triglyceride levels
We conducted a genome-wide linkage scan to detect loci that influence the levels of fasting triglycerides in plasma. Fasting triglyceride levels were...
-
A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern
Background/ObjectivesIndividual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested...
-
Clinicopathological impacts of DNA methylation alterations on pancreatic ductal adenocarcinoma: prediction of early recurrence based on genome-wide DNA methylation profiling
PurposeThe present study was conducted to clarify the clinicopathological impacts of DNA methylation alterations on pancreatic ductal adenocarcinoma...
-
The genetics of Graves’ disease
Graves’ disease (GD) is the commonest cause of hyperthyroidism and has a strong female preponderance. Everyday clinical practice suggests strong...
-
A genome-wide association study on fish consumption in a Japanese population—the Japan Multi-Institutional Collaborative Cohort study
Background/objectiveAlthough benefits of fish consumption for health are well known, a significant percentage of individuals dislike eating fish....
-
A genome-wide association study on medulloblastoma
IntroductionMedulloblastoma is a malignant embryonal tumor of the cerebellum that occurs predominantly in children. To find germline genetic variants...
-
Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium
To provide insights into the biology of opioid dependence (OD) and opioid use (i.e., exposure, OE), we completed a genome-wide analysis comparing...
-
Relationship between autism and brain cortex surface area: genetic correlation and a two-sample Mendelian randomization study
BackgroundAlterations in surface area (SA) in specific regions of the cortex have been reported in many individuals with autism spectrum disorder...
-
Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
Developmental dyslexia (DD) is one of the most prevalent learning disorders, with high impact on school and psychosocial development and high...
-
The genetic landscape of substance use disorders
Substance use disorders represent a significant public health concern with considerable socioeconomic implications worldwide. Twin and family-based...
