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Sirtuin-1 level and gene polymorphisms in multiple sclerosis
BackgroundSirtuin-1 (SIRT1) may affect multiple sclerosis (MS) disease. This study aimed to investigate the level of serum SIRT1, mRNA expression and...
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Vitamin D receptor gene polymorphisms and multiple myeloma: a meta-analysis
Vitamin D acts through the vitamin D receptor (VDR), and vitamin D level decreases in multiple myeloma (MM) patients. Single nucleotide polymorphisms...
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Neuroblastoma susceptibility and association of N7-methylguanosine modification gene polymorphisms: multi-center case-control study
BackgroundNeuroblastoma (NB) is a common extracranial solid malignancy in children. The N7-methylguanosine (m 7 G) modification gene METTL1 / WDR4 ...
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Relationship between BDNF gene polymorphisms and alcohol-related liver cirrhosis
Background and aimBrain-derived neurotrophic factor (BDNF) functions not only in the brain but also in peripheral tissues such as the liver. Genetic...
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Prevalence, associated factors, and gene polymorphisms of obesity in Tibetan adults in Qinghai, China
ObjectivesTo explore the prevalence and associated factors of obesity in Tibetan adults in Qinghai, China, and to determine the association between...
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Association of leptin–melanocortin gene polymorphisms with the risk of obesity in northwest Indian population
BackgroundObesity, a multifaceted endocrine issue, is adversely affecting all age groups and is posing a significant public health challenge. The...
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ACE I/D gene polymorphisms and polycystic ovary syndrome manifestations
ObjectivePolycystic ovary syndrome (PCOS) is a common multifactorial endocrine disorder affecting women of reproductive age. ACE enzyme is involved...
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ADIPOQ gene (T45G and G276T) single nucleotide polymorphisms and their association with gestational diabetes mellitus in a Filipino population
Several studies have associated the presence of ADIPOQ gene polymorphisms with insulin resistance, adiponectin levels, and metabolic diseases such as...
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DIAPH2 gene polymorphisms and laryngeal cancer risk in men
BackgroundThe DIAPH2 gene is one of the genes commonly associated with laryngeal squamous cell carcinoma (LSCC). In our study, we considered the...
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Association of maternal phthalates exposure and metabolic gene polymorphisms with congenital heart diseases: a multicenter case-control study
BackgroundThe majority of congenital heart diseases (CHDs) are thought to result from the interactions of genetics and the environment factors. This...
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Four microRNA gene polymorphisms are associated with Iraqi patients with colorectal cancer
BackgroundColorectal cancer (CRC) is a major cause to global cancer-related mortality. The development of colorectal cancer is linked to hereditary...
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Angiotensin-converting enzyme 1 gene polymorphisms in patients with systemic sclerosis-associated interstitial lung disease: a single centre retrospective observational study
Angiotensin-converting enzyme (ACE) 1 gene polymorphisms have been associated with vascular permeability, alveolar endothelial dysfunction and...
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Vitamin D receptor and vitamin D binding protein gene polymorphisms in patients with asthma: a pilot study
BackgroundThe effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D binding protein (VDBP). Polymorphisms...
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Association of BMAL1 clock gene polymorphisms with fasting glucose in children
BackgroundThe brain and muscle Arnt-like protein-1 ( BMAL1 ) gene is an important circadian clock gene and previous studies have found that certain...
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Gene polymorphisms and thyroid hormone signaling: implication for the treatment of hypothyroidism
IntroductionMutations and single nucleotide polymorphisms (SNPs) in the genes encoding the network of proteins involved in thyroid hormone signaling...
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Association of serotonin receptor gene polymorphisms with anorexia nervosa: a systematic review and meta-analysis
PurposeSeveral studies have investigated the association between anorexia nervosa and polymorphisms of genes regulating serotonin neurotransmission,...
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Correlation between vascular endothelial growth factor A gene polymorphisms and tendon and ligament injury risk: a systematic review and meta-analysis
BackgroundRelevant evidence suggests that angiogenic factors contribute significantly to fibril matrix reconstruction following physical injuries to...
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Factor VII R353Q (rs6046), FGA A6534G (rs6050), and FGG C10034T (rs2066865) Gene Polymorphisms and Risk of Recurrent Pregnancy Loss in Iranian Women
Recurrent pregnancy loss is a multi factorial and heterogeneous disorder defined as two or more consecutive pregnancy losses before 20 weeks’...
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Effect of apolipoprotein E (APOE) gene polymorphisms on the lipid profile of children being treated for acute lymphoblastic leukemia
BackgroundMedications used to treat acute lymphoblastic leukemia (ALL), such as l -asparaginase, can cause blood lipid disturbances. These can also...
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Novel polymorphisms in the prion protein gene (PRNP) and stability of the resultant prion protein in different horse breeds
Prion diseases are fatal neurodegenerative disorders in which the main pathogenic event is the conversion of the cellular prion protein (PrP C ) into...
