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Role of osteoprotegerin rs3102735 gene polymorphism in acute ischemic stroke patients
BackgroundIschemic stroke ranks third among leading causes of death and disability. Both endothelial and vascular smooth muscle cells generate...
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Syntaxin 1A gene polymorphism in multiple sclerosis: a case–control study
BackgroundSyntaxin 1A is a member of a membrane-integrated nervous system-specific protein superfamily involved in the neuromediator release from...
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Association of deletion polymorphism rs10573247 in the HMGA2 gene with the risk of breast cancer: bioinformatic and experimental analyses
BackgroundThe high mobility group A2 (HMGA2) gene is expressed extensively during early embryonic development but is inactivated in adulthood, and it...
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Association between the oxidative stress gene polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis
BackgroundThe association between the oxidative stress gene polymorphism and chronic obstructive pulmonary disease (COPD) risk has been extensively...
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Cytokine gene polymorphism with type 2 diabetes and diabetic nephropathy in population from West India
ObjectiveGenetic polymorphisms of the angiogenesis, inflammatory cascade, or apoptosis genes can influence chronic complications in diabetic...
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Potential role of glutathione S‑transferase M1 gene polymorphism in kidney calcium oxalate stone formation
BackgroundThe purpose of this study was to look into the effects of glutathione S-transferase M1 ( GSTM1 ) gene polymorphism on the formation of...
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Assessment of interleukin-18 gene polymorphism and serum levels in cutaneous lichen planus
BackgroundLichen planus (LP) is a chronic inflammatory disease with uncertain etiology. Interleukin-18 (IL-18) is an interferon gamma (INFγ) inducing...
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Correlation between gene polymorphism and adverse reactions of high-dose methotrexate in osteosarcoma patients: a systematic review and meta-analysis
ObjectiveWe aimed to provide a reference based on evidence for an individualized clinical medication of high-dose methotrexate (HD-MTX) in...
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Study of transcription factor 7-like 2 (TCF7L2) gene polymorphism in cirrhotic patients with diabetes
Patients with chronic liver disease (CLD) as chronic hepatitis C (CHC) are at high risk of diabetes type 2 (T2D). Genetic factors are suggested to...
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The role of vitamin D receptor gene polymorphism in the development of necrotizing enterocolitis
BackgroundVitamin D and its receptor (VDR) effects on the gastrointestinal system are among its most critical multisystemic effects.
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The association of growth differentiation factor 5 rs143383 gene polymorphism with osteoarthritis: a systematic review and meta-analysis
BackgroundOsteoarthritis (OA) is caused by a complex set of pathophysiological factors. The genetic factors involved in the occurrence and progress...
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MDM2 Gene rs2279744 Polymorphism and Breast Cancer Risk: Evidence from Meta-Analysis and Meta-Regression Analysis
BackgroundSeveral case–control studies have previously assessed the association of mouse double minute 2 homolog (MDM2) gene rs2279744 ...
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Adiponectin rs1501299 and chemerin rs17173608 gene polymorphism in children with type 1 diabetes mellitus: relation with macroangiopathy and peripheral artery disease
AimAlthough macrovascular complications represent the leading cause of mortality in type 1 diabetes mellitus (T1DM), the prevalence of subtle...
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Vitamin D deficiency and VDR gene polymorphism FokI (rs2228570) are associated with diabetes mellitus in adults: COVID-inconfidentes study
BackgroundDiabetes mellitus is a chronic and multifactorial condition, including environmental risk factors such as lifestyle habits and genetic...
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The influence of CDKAL1 (rs7754840) gene polymorphism on susceptibility to gestational diabetes mellitus in pregnant women: a systematic review and meta-analysis
ObjectiveGene polymorphisms CDKAL1 (rs7754840) have been related to type 2 diabetes mellitus, which may partially define the common genetic...
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Quantitative assessment of the associations between DNA repair gene XRCC3 Thr241Met polymorphism and pancreatic cancer
BackgroundPrior research exploring the correlation between the XRCC3 Thr241Met polymorphism and the susceptibility to pancreatic cancer has yielded...
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Role of rs9939506 polymorphism of FTO gene in resistance to eating in male adolescents
BackgroundSingle Nucleotide Polymorphisms (SNPs) of the Fat mass and obesity-associated ( FTO ) gene may be associated with obesity by regulating...
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Relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and neutrophil gelatinase-associated lipocalin in early renal injury in H-type hypertension
ObjectiveTo analyse the relationship between the polymorphisms of the H-type hypertensive methylenetetrahydrofolate reductase (MTHFR) C677T gene and...
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Association between interleukin-6-174G/C gene polymorphism and asthma severity: exploring the role of total serum IgE, blood eosinophils, and FeNO as markers of type 2 inflammation
BackgroundWhile a connection has been established between serum interleukin-6 ( IL-6 ) levels and the IL-6 gene (− 174G/C) polymorphism in allergic...
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Polymorphism rs5780218, rs12998 and rs10158616 in KISS1 gene among the Hubei province Chinese girls with the central precocious puberty
PurposeCentral precocious puberty (CPP) results from early activation of the hypothalamic-pituitary-gonadal (HPG) axis. To elucidate the molecular...
