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Development and application of Chinese medical ontology for diabetes mellitus
ObjectiveTo develop a Chinese Diabetes Mellitus Ontology (CDMO) and explore methods for constructing high-quality Chinese biomedical ontologies.
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Homeostasis imbalance process ontology: a study on COVID-19 infectious processes
BackgroundOne significant challenge in addressing the coronavirus disease 2019 (COVID-19) pandemic is to grasp a comprehensive picture of its...
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An ontology-based approach for modelling and querying Alzheimer’s disease data
BackgroundThe recent advances in biotechnology and computer science have led to an ever-increasing availability of public biomedical data distributed...
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Big knowledge visualization of the COVID-19 CIDO ontology evolution
BackgroundThe extensive international research for medications and vaccines for the devastating COVID-19 pandemic requires a standard reference...
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Gene ontology enrichment analysis of PPAR-γ modulators from Cassia glauca in diabetes mellitus
BackgroundPPAR-γ has an integrative role in the management of insulin resistance; ligands of this receptor have emerged as potent insulin sensitizers...
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Automatic diagnosis of COVID-19 infection based on ontology reasoning
Background2019-nCoV has been spreading around the world and becoming a global concern. To prevent further widespread of 2019-nCoV, confirmed and...
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Semantic clustering analysis of E3-ubiquitin ligases in gastrointestinal tract defines genes ontology clusters with tissue expression patterns
BackgroundUbiquitin ligases (Ub-ligases) are essential intracellular enzymes responsible for the regulation of proteome homeostasis, signaling...
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Novel biomarkers identified by weighted gene co-expression network analysis for atherosclerosis
BackgroundThis study aimed to screen out the potential diagnostic biomarkers for atherosclerosis (AS).
MethodsWe downloaded the gene expression...
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Disease-specific differences in gene expression, mitochondrial function and mitochondria-endoplasmic reticulum interactions in iPSC-derived cerebral organoids and cortical neurons in schizophrenia and bipolar disorder
We compared transcriptomic profiles of cerebral organoids differentiated from induced pluripotent stem cells of eight schizophrenia and eight bipolar...
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Hub gene of disulfidptosis-related immune checkpoints in breast cancer
Disulfidptosis and immune checkpoint genes play an important role in tumor treatment. But there has been less research on the relationship between...
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Expediting knowledge acquisition by a web framework for Knowledge Graph Exploration and Visualization (KGEV): case studies on COVID-19 and Human Phenotype Ontology
BackgroundKnowledges graphs (KGs) serve as a convenient framework for structuring knowledge. A number of computational methods have been developed to...
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The Gene Expression Profiles Associated with Maternal Nicotine Exposure in the Liver of Offspring Mice
This study aims to investigate the effect of maternal nicotine exposure on the gene expression profiles in the liver of offspring mice. Pregnant mice...
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Immunophenotypic and Gene Expression Analyses of the Inflammatory Microenvironment in High-Grade Oral Epithelial Dysplasia and Oral Lichen Planus
BackgroundOral lichen planus (OLP) and oral epithelial dysplasia (OED) present diagnostic challenges due to clinical and histologic overlap. This...
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Novel cuproptosis-related prognostic gene profiles in preeclampsia
BackgroundPreeclampsia (PE) is a pregnancy-specific disorder with complex pathogenesis. Cuproptosis is a novel identified form of programmed cell...
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A prognostic gene signature for gastric cancer and the immune infiltration-associated mechanism underlying the signature gene, PLG
BackgroundGlobally, gastric cancer (GC) is a common and lethal solid malignant tumor. Identifying the molecular signature and its functions can...
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Evaluation of the gene fusion landscape in early onset sporadic rectal cancer reveals association with chromatin architecture and genome stability
Gene fusions represent a distinct class of structural variants identified frequently in cancer genomes across cancer types. Several gene fusions...
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Erythritol alters gene transcriptome signatures, cell growth, and biofilm formation in Staphylococcus pseudintermedius
BackgroundErythritol was found to inhibit the growth of microorganisms. The present study aimed to demonstrate the growth inhibition of Staphylococcus...
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The identification of hub genes associated with pure ground glass nodules using weighted gene co-expression network analysis
BackgroundWhether there are invasive components in pure ground glass nodules(pGGNs) in the lungs is still a huge challenge to forecast. The objective...
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Comparing gene expression in deep infiltrating endometriosis with adenomyosis uteri: evidence for dysregulation of oncogene pathways
BackgroundThe pathogenesis of deep infiltrating endometriosis (DIE) is poorly understood. It is considered a benign disease but has histologic...
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Catecholamine treatment induces reversible heart injury and cardiomyocyte gene expression
BackgroundCatecholamines are commonly used as therapeutic drugs in intensive care medicine to maintain sufficient organ perfusion during shock....
