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Gene expression networks regulated by human personality
Genome-wide association studies of human personality have been carried out, but transcription of the whole genome has not been studied in relation to...
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Bronchial epithelial gene expression and interstitial lung abnormalities
IntroductionInterstitial lung abnormalities (ILA) often represent early fibrotic changes that can portend a progressive fibrotic phenotype. In...
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Radiation-induced changes in gene expression in rectal cancer specimens
PurposeThe standard-of-care for locally advanced rectal cancer is radiotherapy-based neoadjuvant therapy followed by surgical resection. This article...
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Luteolin promotes KAT6A gene expression
De novo, rare, and genomic variants in the KAT6A gene have been associated with cases of intellectual disability with speech/language impairment. The...
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Temporal changes of gene expression in health, schizophrenia, bipolar disorder, and major depressive disorder
The molecular events underlying the development, manifestation, and course of schizophrenia, bipolar disorder, and major depressive disorder span...
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The Alzheimer’s disease risk gene BIN1 regulates activity-dependent gene expression in human-induced glutamatergic neurons
Bridging Integrator 1 ( BIN1 ) is the second most important Alzheimer’s disease (AD) risk gene, but its physiological roles in neurons and its...
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Association of protein distribution and gene expression revealed by positron emission tomography and postmortem gene expression in the dopaminergic system of the human brain
PurposeThe topological distribution of dopamine-related proteins is determined by gene transcription and subsequent regulations. Recent research...
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Gene expression of hemostasis biomarkers following HIIT and RIPC
To prevent and manage cardiovascular risk factors, two effective strategies are remote ischemic preconditioning and regular exercise training. The...
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Brain-based gene expression of putative risk genes for anorexia nervosa
The etiology of anorexia nervosa (AN) remains elusive. Recent genome-wide association studies identified the first genes liked to AN which reached...
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DYT-THAP1: exploring gene expression in fibroblasts for potential biomarker discovery
Dystonia due to pathogenic variants in the THAP1 gene (DYT-THAP1) shows variable expressivity and reduced penetrance of ~ 50%. Since THAP1 encodes a...
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Fetal programming and lactation: modulating gene expression in response to undernutrition during intrauterine life
BackgroundAdverse environmental conditions during intrauterine life, known as fetal programming, significantly contribute to the development of...
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Catecholamine treatment induces reversible heart injury and cardiomyocyte gene expression
BackgroundCatecholamines are commonly used as therapeutic drugs in intensive care medicine to maintain sufficient organ perfusion during shock....
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Gene expression profiles separate endometriosis lesion subtypes and indicate a sensitivity of endometrioma to estrogen suppressive treatments through elevated ESR2 expression
BackgroundEndometriosis is a common, gynaecological disease characterised by the presence of endometrial-like cells growing outside the uterus....
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Novel biomarkers identified by weighted gene co-expression network analysis for atherosclerosis
BackgroundThis study aimed to screen out the potential diagnostic biomarkers for atherosclerosis (AS).
MethodsWe downloaded the gene expression...
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Genetic and Gene Expression Resources for Osteoporosis and Bone Biology Research
Purpose of ReviewThe integration of data from multiple genomic assays from humans and non-human model organisms is an effective approach to identify...
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Bipolar patients display stoichiometric imbalance of gene expression in post-mortem brain samples
Bipolar disorder is a severe neuro-psychiatric condition where genome-wide association and sequencing studies have pointed to dysregulated gene...
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Psychosocial stressors and breast cancer gene expression in the Black Women’s Health Study
PurposePrior studies indicate that the physiologic response to stress can affect gene expression. We evaluated differential gene expression in breast...
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BrainGENIE: The Brain Gene Expression and Network Imputation Engine
In vivo experimental analysis of human brain tissue poses substantial challenges and ethical concerns. To address this problem, we developed a...
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Antipsychotic drug use complicates assessment of gene expression changes associated with schizophrenia
Recent postmortem transcriptomic studies of schizophrenia (SCZ) have shown hundreds of differentially expressed genes. However, the extent to which...
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Identification of a gene expression signature associated with brain metastasis in colorectal cancer
PurposeBrain metastasis (BM) in colorectal cancer (CRC) is a rare event with poor prognosis. Apart from (K)RAS status and lung and bone metastasis no...
