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Association of obesity and menarche SNPs and interaction with environmental factors on precocious puberty
BackgroundObesity is an important cause for the precocious or early puberty. However, the association between obesity-related loci and the risk of...
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Epigenetics and environmental health
Epigenetic modifications including DNA methylation, histone modifications, chromatin remodeling, and RNA modifications complicate gene regulation and...
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Evidence of gene-nutrient interaction association with waist circumference, cross-sectional analysis
Background and aimsWaist circumference (WC) is a significant indicator of body adiposity and is associated with increased mortality and morbidity of...
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Case-only approach applied in environmental epidemiology: 2 examples of interaction effect using the US National Health and Nutrition Examination Survey (NHANES) datasets
IntroductionBy substituting the general ‘susceptibility factor’ concept for the conventional ‘gene’ concept in the case-only approach for...
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Identification of candidate genes and chemicals associated with osteoarthritis by transcriptome-wide association study and chemical-gene interaction analysis
BackgroundOsteoarthritis (OA) is a common degenerative joint disease and causes chronic pain and disability to the elderly. Several risk factors are...
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Dissecting schizophrenia phenotypic variation: the contribution of genetic variation, environmental exposures, and gene–environment interactions
Schizophrenia is among the leading causes of disability worldwide. Prior studies have conclusively demonstrated that the etiology of schizophrenia...
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Interaction of childhood trauma with BDNF and FKBP5 gene polymorphisms in predicting burnout in general occupational groups
Both the BDNF gene rs6265 and the FKBP5 gene rs1360780 polymorphisms are independently associated with adult psychotic-like experiences, when exposed...
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Interaction of base excision repair gene polymorphism and estrogen-DNA adducts in breast cancer risk among East Asian women
PurposeIn East Asia, the incidence of breast cancer has been increasing rapidly, particularly among premenopausal women. An elevated ratio of...
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Prenatal exposure to environmental air pollution and psychosocial stress jointly contribute to the epigenetic regulation of the serotonin transporter gene in newborns
Antenatal exposures to maternal stress and to particulate matter with an aerodynamic diameter of less than 2.5 μm (PM 2.5 ) have been independently...
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Disordered eating in early childhood: DRD4 and DAT1 gene polymorphisms and quality of mother–child interaction
PurposeEating disturbances are complex heritable conditions that can be influenced by both genetic and environmental factors but are poorly studied...
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Association between birth by caesarian section and anxiety, self-harm: a gene-environment interaction study using UK Biobank data
BackgroundLimited efforts have been paid to explore the underlying genetic mechanisms of birth by caesarian section (CS) affecting the risks of adult...
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Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn’s disease: a multi-omics Mendelian randomization study
BackgroundOxidative stress (OS) is a key pathophysiological mechanism in Crohn’s disease (CD). OS-related genes can be affected by environmental...
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The interaction between MC4R gene variant (rs17782313) and dominant dietary patterns on depression in obese and overweight women: a cross sectional study
BackgroundPrevious studies have shown that the minor allele (C allele) for melanocortin 4 receptor (MC4R) rs17782313 may be associated with depressed...
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Time moderates the interplay between 5-HTTLPR and stress on depression risk: gene x environment interaction as a dynamic process
The serotonin-transporter-linked promoter region (5-HTTLPR) has been widely investigated as contributing to depression vulnerability. Nevertheless,...
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Influences of Genetic and Environmental Factors on Chronic Migraine: A Narrative Review
Purpose of ReviewIn this narrative review, we aim to summarize recent insights into the complex interplay between environmental and genetic factors...
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Influence of blood pressure polygenic risk scores and environmental factors on coronary artery disease in the Korean Genome and Epidemiology Study
The present study aimed to investigate the association of blood pressure polygenic risk scores (BP PRSs) with coronary artery disease (CAD) in a...
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Healthy beverages may reduce the genetic risk of abdominal obesity and related metabolic comorbidities: a gene-diet interaction study in Iranian women
Background & aimsThe nutrition transition in develo** countries like Iran causes the increasing rise of obesity and abdominal obesity rates....
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Prevalence, associated factors, and gene polymorphisms of obesity in Tibetan adults in Qinghai, China
ObjectivesTo explore the prevalence and associated factors of obesity in Tibetan adults in Qinghai, China, and to determine the association between...
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Gene – maltreatment interplay in adult ADHD symptoms: main role of a gene–environment correlation effect in a Brazilian population longitudinal study
Childhood maltreatment correlates with attention-deficit/hyperactivity disorder (ADHD) in previous research. The interaction between ADHD genetic...
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Interaction between HTR2A rs3125 and negative life events in suicide attempts among patients with major depressive disorder: a cross-sectional study
BackgroundBoth genetic and environmental factors play crucial roles in the development of major depressive disorder (MDD) and suicide attempts (SA)....
