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Cannabigerol (CBG) signal enhancement in its analysis by gas chromatography coupled with tandem mass spectrometry
PurposeAccording to recent reports, cannabigerol (CBG) concentration level in blood and body fluids may have forensic utility as a highly specific...
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Assessment of pheniramine in alternative biological matrices by liquid chromatography tandem mass spectrometry
Pheniramine is an over-the-counter antihistamine drug. Its accessibility and low cost made it more popular among drug abusers in Pakistan. In this...
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Comprehensive chemical profiling of volatile constituents of Angong Niuhuang Pill in vitro and in vivo based on gas chromatography coupled with mass spectrometry
BackgroundAngong Niuhuang Pill (ANP), a renowned precious traditional Chinese medicine prescription, is extensively utilized for the clinical...
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Simultaneous determination of water-soluble herbicides using hydrophilic interaction liquid chromatography–mass spectrometry
PurposeThe analysis of water-soluble herbicides, including glyphosate (Glyp), glufosinate (Gluf), paraquat (PQ), and diquat (DQ), is time-consuming...
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Urinary metabolomics using gas chromatography-mass spectrometry: potential biomarkers for autism spectrum disorder
BackgroundDiagnosis of autism spectrum disorder (ASD) is generally made phenotypically and the hunt for ASD-biomarkers continues. The purpose of this...
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Quantification of MDMB-4en-PINACA and ADB-BUTINACA in human hair by gas chromatography–tandem mass spectrometry
PurposeTo test synthetic cannabinoid (SCs) in parent forms from living human, the hairs seems to be one of the best samples, because of the...
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Semi-quantitative analysis of cannabinoids in hemp (Cannabis sativa L.) using gas chromatography coupled to mass spectrometry
BackgroundHemp ( Cannabis sativa L.) is a producer of cannabinoids. These organic compounds are of increasing interest due to their potential...
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Quantitation of sibutramine in human hair using gas chromatography–isotope dilution tandem mass spectrometry
PurposeAn analytical method for quantitation of sibutramine in human hair using gas chromatography (GC)–isotope dilution tandem mass spectrometry...
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Characterization of ginsenosides from Panax japonicus var. major (Zhu-Zi-Shen) based on ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry and desorption electrospray ionization-mass spectrometry imaging
BackgroundPanax japonicus var. major (PJM) belongs to the well-known ginseng species used in west China for hundreds of years, which has the effects...
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Identification of changes in bile composition in pancreaticobiliary reflux based on liquid chromatography/mass spectrometry metabolomics
IntroductionPancreaticobiliary reflux (PBR) can induce gallstone formation; however, its pathogenic mechanism remains unclear. In this study, we...
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Study on the mechanism of moxibustion for rheumatoid arthritis based on liquid chromatography-mass spectrometry
ObjectiveTo explore the mechanism of moxibustion for rheumatoid arthritis (RA) by observing the metabolite changes in urine using liquid...
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Liquid chromatography-mass spectrometry-based metabolomic profiling reveals sex differences of lipid metabolism among the elderly from Southwest China
BackgroundThe sexual dimorphism represents one of the triggers of the metabolic disparities while the identification of sex-specific metabolites in...
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Exploring the aging process of cognitively healthy adults by analyzing cerebrospinal fluid metabolomics using liquid chromatography-tandem mass spectrometry
BackgroundDuring biological aging, significant metabolic dysregulation in the central nervous system may lead to cognitive decline and...
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Analysis of degradation products of Novichok agents in human urine by hydrophilic interaction liquid chromatography–tandem mass spectrometry
PurposeThe detection of hydrolysis products of Novichok agents in biological samples from victims is important for confirming exposure to these...
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Green analytical toxicology method for determination of synthetic cathinones in oral fluid samples by microextraction by packed sorbent and liquid chromatography–tandem mass spectrometry
PurposeWe developed and validated a method for quantitative analysis of ten synthetic cathinones in oral fluid (OF) samples, using microextraction by...
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Urine metabolomics for assessing fertility-sparing treatment efficacy in endometrial cancer: a non-invasive approach using ultra-performance liquid chromatography mass spectrometry
ObjectiveThis study aimed to reveal the urine metabolic change of endometrial cancer (EC) patients during fertility-sparing treatment and establish...
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Chiral analysis of dextromethorphan and levomethorphan in human hair by liquid chromatography–tandem mass spectrometry
PurposeMethorphan exists in two enantiomeric forms including dextromethorphan and levomethorphan. Dextromethorphan is an over-the-counter antitussive...
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Pharmacokinetic study of the main components of Tanreqing capsules and Tanreqing injections in beagles by liquid chromatography–tandem mass spectrometry
BackgroundTanreqing capsules (TRQCs) and Tanreqing injections (TRQIs) are widely used in the treatment of respiratory diseases. In this study, a...
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First liquid chromatography–high resolution mass spectrometry method for the determination of cocaine on banknote dust
PurposePrevalence measures of sociological interest concerning cocaine presence on banknotes are fraught with (i) the extreme variability of its...
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Analysis of degradation products of nerve agents in biological fluids by ion chromatography–tandem mass spectrometry
PurposeThe detection of hydrolysis products of nerve agents (alkyl methylphosphonic acids; RMPAs) in biological samples from victims is important to...