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Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurological condition characterized by impaired cognitive function and behavioral alterations. While AD...
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GM2 gangliosidosis AB variant: first case of late onset and review of the literature
AB variant is the rarest form of GM2 gangliosidosis, neurodegenerative diseases caused by lysosomal accumulation of GM2 gangliosides. Less than...
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Co-occurrence of polyneuritis crainials and visual impairment: a case report and literature review
BackgroundPolyneuritis cranialis (PNC) with the disease characteristics of Guillain-Barré syndrome (GBS) in addition to both ocular and bulbar...
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Anti-sulfatide antibody associated GBS with headache and abdominal pain: a case report
BackgroundGuillain‒Barre syndrome (GBS) is an acute inflammatory peripheral neuropathy caused by autoimmunity. Gangliosides and sulfatides are...
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A case of spastic paraplegia type 11 mimicking a GM2-gangliosidosis
IntroductionSpastic paraplegia type 11 (SPG11) is the most frequent autosomal recessive HSP. Studies on SPG11 patients’ fibroblasts, post-mortem...
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FLOT1 knockdown inhibits growth of AML cells through triggering apoptosis and pyroptosis
Acute myeloid leukemia (AML) is a group of hematological malignancies characterized by clonal proliferation of immature myeloid cells. Lipid rafts...
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Milk fat globule membrane attenuates high fat diet-induced neuropathological changes in obese Ldlr−/−.Leiden mice
BackgroundMilk-fat globule membrane (MFGM) is a complex structure secreted by the mammary gland and present in mammalian milk. MFGM contains lipids...
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Inter-laboratory comparison of routine autoantibody detection methods for autoimmune neuropathies and myasthenia gravis
Serological tests are important to detect autoantibodies (autoAbs) in patients with autoimmune neuropathies (AN) and myasthenia gravis (MG) as they...
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The presence and clinical significance of autoantibodies in amyotrophic lateral sclerosis: a narrative review
Amyotrophic lateral sclerosis (ALS) is a debilitating and rapidly fatal neurodegenerative disease, which is characterized by the selective loss of...
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A case of variant of GBS with positive serum ganglioside GD3 IgG antibody
BackgroundAcute bulbar palsy-plus (ABPp) syndrome is an unusual variant of Guillain-Barré syndrome (GBS). Anti-GT1a and anti-GQ1b antibodies have...
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7,8-Dihydroxyflavone induces mitochondrial apoptosis and down-regulates the expression of ganglioside GD3 in malignant melanoma cells
Malignant melanoma is a skin cancer with poor prognosis and high resistance to conventional treatment. 7,8-dihydroxyflavone (7,8-DHF) has shown...
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The spectrum of anti-GQ1B antibody syndrome: beyond Miller Fisher syndrome and Bickerstaff brainstem encephalitis
IntroductionSince the initial identification of Miller Fisher syndrome (MFS) and Bickerstaff brainstem encephalitis (BBE),significant milestones have...
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Is there a causal nexus between COVID-19 infection, COVID-19 vaccination, and Guillain-Barré syndrome?
Guillain-Barré syndrome (GBS) is an immune-mediated inflammatory polyradiculoneuropathy, which commonly leads to a very high level of neurological...
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Frequency and clinical correlates of anti-nerve antibodies in a large population of CIDP patients included in the Italian database
ObjectiveTo investigate the frequency and clinical correlates of anti-nerve autoantibodies in an unselected series of Italian patients with chronic...
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Clinical, paraclinical and outcome features of 166 patients with acute anti-GQ1b antibody syndrome
Background & purposeIn this retrospective study, we aimed at defining the clinical, paraclinical and outcome features of acute neurological syndromes...
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More than meets the eye in Parkinson’s disease and other synucleinopathies: from proteinopathy to lipidopathy
The accumulation of proteinaceous inclusions in the brain is a common feature among neurodegenerative diseases such as Alzheimer’s disease,...
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Decreased GM3 correlates with proteinuria in minimal change nephrotic syndrome and focal segmental glomerulosclerosis
BackgroundGlycolipids on cell membrane rafts play various roles by interacting with glycoproteins. Recently, it was reported that the glycolipid GM3...
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Immune-mediated neurological syndromes in SARS-CoV-2-infected patients
BackgroundEvidence of immune-mediated neurological syndromes associated with the severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection...
