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GPR30 receptor promotes preoperative anxiety-induced postoperative hyperalgesia by up-regulating GABAA-α4β1δ subunits in periaqueductal gray in female rats
BackgroundG-protein coupled estrogen receptor 30 (GPR30) was proved the specific estrogen receptor relating to mechanical hyperalgesia. Studies have...
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Targeting estrogen receptor signaling for treating heart failure
Heart failure (HF) is a significant public health problem worldwide. It has long been noted that premenopausal women, compared to postmenopausal...
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The G protein-coupled oestrogen receptor GPER in health and disease: an update
Oestrogens and their receptors contribute broadly to physiology and diseases. In premenopausal women, endogenous oestrogens protect against...
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Neuroactive steroids in the neuroendocrine control of food intake, metabolism, and reproduction
Neuroactive steroids are a type of steroid hormones produced within the nervous system or in peripheral glands and then transported to the brain to...
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Hypermethylated GPR135 gene expression is a favorable independent prognostic factor in nasopharyngeal carcinoma
PurposeTo investigate the methylation status and expression level of G protein-coupled receptor 135 (GPR135) in nasopharyngeal carcinoma (NPC) and...
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Mitochondrial Genetics and Function as Determinants of Bone Phenotype and Aging
Purpose of ReviewThe purpose of this review is to summarize the recently published scientific literature regarding the effects of mitochondrial...
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Bisphenol A and bisphenol S both disrupt ovine granulosa cell steroidogenesis but through different molecular pathways
BackgroundOvarian granulosa cells (GC) are essential for the development and maturation of a proper oocyte. GC are sensitive to endocrine disruptors,...
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The Role of Abnormal Uterine Junction Zone in the Occurrence and Development of Adenomyosis
Adenomyosis is a benign disease with a malignant behavior, bothering a lot of women at reproductive age who suffer from increased menstruation,...
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Unraveling the molecular mechanisms driving enhanced invasion capability of extravillous trophoblast cells: a comprehensive review
Precise extravillous trophoblast (EVT) invasion is crucial for successful placentation and pregnancy. This review focuses on elucidating the...
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The Roles of Orphan G Protein-Coupled Receptors in Autoimmune Diseases
G protein-coupled receptors (GPCRs) constitute the largest family of plasma membrane receptors in nature and mediate the effects of a variety of...
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Endocrine disruptor chemicals, adipokines and reproductive functions
The prevalence of adult obesity has risen markedly in recent decades. The endocrine system precisely regulates energy balance, fat abundance and fat...
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Sexual dimorphism in reactive oxygen species production and a role for integrin α1β1 in estrogen receptor α and β expression in articular cartilage
BackgroundOsteoarthritis (OA) is a debilitating disease involving cartilage degradation. A need remains for the discovery of new molecular targets in...
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Phytometabolites as modulators of breast cancer: a comprehensive review of mechanistic insights
Breast cancer (BC) is a highly debilitating malignancy affecting females globally and imposing a substantial burden on healthcare systems in both...
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Interdisziplinäre Diagnostik und Therapie der Migräne bei Frauen
Women of reproductive age are affected by migraine much more frequently than men of the same age. Studies have shown that estrogens can indirectly...
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Low back pain and osteoarthritis pain: a perspective of estrogen
Low back pain (LBP) is the world’s leading cause of disability and is increasing in prevalence more rapidly than any other pain condition....
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ErbB2-upregulated HK1 and HK2 promote breast cancer cell proliferation, migration and invasion
ErbB2 is overexpressed in 15-20% of breast cancer, which is associated with malignancy and poor prognosis. We previously reported that ErbB2 supports...
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Mind the Gap: Unraveling the Intricate Dance Between Alzheimer’s Disease and Related Dementias and Bone Health
Purpose of ReviewThis review examines the linked pathophysiology of Alzheimer’s disease/related dementia (AD/ADRD) and bone disorders like...
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Neuroendocrinology of sexual behavior
One of the consequences of sexual behavior is reproduction. Thus, this behavior is essential for the survival of the species. However, the individual...
