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FGF19 and FGFR4 promotes the progression of gallbladder carcinoma in an autocrine pathway dependent on GPBAR1-cAMP-EGR1 axis
Treatment options for gallbladder carcinoma (GBC) are limited and GBC prognosis remains poor. There is no well-accepted targeted therapy to date, so...
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Bile Acid Signaling in Inflammatory Bowel Diseases
Bile acids are a group of chemically different steroids generated at the host/microbial interface. Indeed, while primary bile acids are the...
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Dietary carbon loaded with nano-ZnO alters the gut microbiota community to mediate bile acid metabolism and potentiate intestinal immune function in fattening beef cattle
BackgroundTo our knowledge, carbon loaded with nano-ZnO (NZnOC) represents a new nutritional additive for the animal husbandry industry. However, the...
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The interaction of bile acids and gut inflammation influences the pathogenesis of inflammatory bowel disease
Bile acids (BA) are amphipathic molecules originating from cholesterol in the liver and from microbiota-driven biotransformation in the colon. In the...
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Circulating concentrations of bile acids and prevalent chronic kidney disease among newly diagnosed type 2 diabetes: a cross-sectional study
BackgroundThe relationship between circulating bile acids (BAs) and kidney function among patients with type 2 diabetes is unclear. We aimed to...
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Bile acids profile and redox status in healthy infants
BackgroundAt birth, human neonates are more likely to develop cholestasis and oxidative stress due to immaturity or other causes. We aimed to search...
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Gut microbiota in cancer: insights on microbial metabolites and therapeutic strategies
In recent years, the role of gut microbiota in cancer treatment has attracted substantial attention. It is now well established that gut microbiota...
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The Role of Gut Dysbiosis and Potential Approaches to Target the Gut Microbiota in Multiple Sclerosis
It has now been established that a perturbation in gut microbiome composition exists in multiple sclerosis (MS) and its interplay with the immune...
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Identification of key genes and immune infiltration in osteoarthritis through analysis of zinc metabolism-related genes
BackgroundOsteoarthritis (OA) represents a prominent etiology of considerable pain and disability, and conventional imaging methods lack sensitivity...
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Cholestatic Itch: Our Current Understanding of Pathophysiology and Treatments
Hepatic pruritus is common in liver conditions, including cholestasis and nonalcoholic fatty liver disease. The pruritus can be severe enough to...
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The intestine as an endocrine organ and the role of gut hormones in metabolic regulation
Gut hormones orchestrate pivotal physiological processes in multiple metabolically active tissues, including the pancreas, liver, adipose tissue, gut...
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Incorporating the Molecular Mimicry of Environmental Antigens into the Causality of Autoimmune Hepatitis
Molecular mimicry between foreign and self-antigens has been implicated as a cause of autoimmune hepatitis in experimental models and cross-reacting...
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Another renaissance for bile acid gastrointestinal microbiology
The field of bile acid microbiology in the gastrointestinal tract is going through a current rebirth after a peak of activity in the late 1970s and...
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Advances in the molecular understanding of G protein-coupled receptors and their future therapeutic opportunities
BackgroundUnderstanding the mechanisms, activated and inhibited pathways as well as other molecular targets involved in existing and emerging disease...
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Aquaporin 2 regulation: implications for water balance and polycystic kidney diseases
Targeting the collecting duct water channel aquaporin 2 (AQP2) to the plasma membrane is essential for the maintenance of mammalian water...
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Network pharmacological analysis to reveal the mechanism governing the effect of Qin ** Tong on osteoarthritis and rheumatoid arthritis
IntroductionQin ** Tong (QXT), produced by water extracts of Caulis Sinomenii , is clinically effective in the therapy of rheumatoid arthritis (RA)....
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Immunosuppressive effects of circulating bile acids in human endotoxemia and septic shock: patients with liver failure are at risk
BackgroundSepsis-induced immunosuppression is a frequent cause of opportunistic infections and death in critically ill patients. A better...
