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RNA silencing of GM-CSF in CAR-T cells reduces the secretion of multiple inflammatory cytokines
Chimeric antigen receptor T (CAR-T) cell therapy has become a research hotspot in the field of hematological malignancies. However, CAR-T cell...
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Whole lung lavage and GM-CSF use for pulmonary alveolar proteinosis in an infant with lysinuric protein intolerance: a case report
BackgroundLysinuric protein intolerance (LPI) is a multi-organ metabolic disorder characterized by the imbalance in absorption and excretion of...
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Neutralizing GM-CSF autoantibodies in pulmonary alveolar proteinosis, cryptococcal meningitis and severe nocardiosis
BackgroundAnti GM-CSF autoantibodies (aAb) have been related to acquired pulmonary alveolar proteinosis (PAP) and described in cases of severe...
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GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity
Inhibitory myeloid cells and their cytokines play critical roles in limiting chimeric antigen receptor T (CART) cell therapy by contributing to the...
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IL-2/GM-CSF enhances CXCR3 expression in CAR-T cells via the PI3K/AKT and ERK1/2 pathways
ObjectiveTo investigate the effects of cytokines IL-2 and GM-CSF on CXCR3 expression and chemotaxis of CAR-T cells.
BackgroundHigh lymphocyte...
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Lokale Therapie von venösen Ulzera mit niedrig dosiertem rekombinantem, humanem „granulocyte-macrophage colony-stimulating factor“ (rhu GM-CSF), 10 Jahre Nachbeobachtung
BackgroundThe treatment of leg ulcers is an enormous problem worldwide. Chronic venous ulceration affects 1% of the population and often has...
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GM-CSF-mediated inducement of bone marrow MDSCs by TSA and effect on survival of graft in mice
ObjectiveThis study analyzed the effect of HDAC inhibitor, trichostatin A (TSA), in inducing granulocyte–macrophage colony-stimulating factor...
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Serum granulocyte-macrophage colony-stimulating factor (GM-CSF) is increased in patients with active radiographic axial spondyloarthritis and persists despite anti-TNF treatment
BackgroundAccumulating evidence supports the role of monocytes and neutrophils in radiographic axSpA (r-axSpA). Granulocyte-macrophage...
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HER2/neu-based vaccination with li-Key hybrid, GM-CSF immunoadjuvant and trastuzumab as a potent triple-negative breast cancer treatment
PurposeConstituting 15 to 20% of breast cancer cases, the triple-negative subtype lacks effective treatments as being less responsive to...
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Invariant NKT cell-augmented GM-CSF-secreting tumor vaccine is effective in advanced prostate cancer model
Invariant natural killer T cells (iNKT cells) express a semi-invariant T cell receptor that recognizes certain glycolipids (including...
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GM-CSF elicits antibodies to tumor-associated proteins when used as a prostate cancer vaccine adjuvant
Antibody responses to off-target cancer-associated proteins have been detected following immunotherapies for cancer, suggesting these may be the...
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CD73 induces GM-CSF/MDSC-mediated suppression of T cells to accelerate pancreatic cancer pathogenesis
Metabolic alterations regulate cancer aggressiveness and immune responses. Given the poor response of pancreatic ductal adenocarcinoma (PDAC) to...
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CMAHP promotes metastasis by reducing ubiquitination of Snail and inducing angiogenesis via GM-CSF overexpression in gastric cancer
Pseudogenes are generally considered “junk” DNA or “genomic fossils” generated during the evolution process that lack biological activity. However,...
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The feasibility of using an autologous GM-CSF-secreting breast cancer vaccine to induce immunity in patients with stage II–III and metastatic breast cancers
PurposeThe antigenic targets of immunity and the role of vaccination in breast cancer are unknown. We performed a phase I study of an autologous...
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The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML
FLT3-ITD is the most predominant mutation in AML being expressed in about one-third of AML patients and is associated with a poor prognosis. Efforts...
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B7-1 and GM-CSF enhance the anti-tumor immune effect of DC-tumor fusion vaccine in the treatment of prostate cancer
The treatment of castration-resistant prostate cancer (CRPC) is always a difficulty in the clinic. Most patients with localized tumor eventually...
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GM-CSF does not rescue poor-quality embryos: secondary analysis of a randomized controlled trial
PurposeTo evaluate implantation potential of cleavage-stage embryos cultured in medium containing 2 ng/ml granulocyte–macrophage colony-stimulating...
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High Levels of Anti-GM-CSF Antibodies in Deep Infiltrating Endometriosis
Endometriosis is a chronic hormono-dependent inflammatory gynecological disease. Endometriosis can be subdivided into three forms: superficial...
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Combined blockade of TGf-β1 and GM-CSF improves chemotherapeutic effects for pancreatic cancer by modulating tumor microenvironment
The interactions between tumor immune microenvironment (TIME) and pancreatic cancer cells can affect chemotherapeutic efficacy; however, the...
