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Evaluation of glucocorticoid-induced TNF receptor (GITR) expression in breast cancer and across multiple tumor types
Glucocorticoid-induced TNF receptor (GITR) is an emerging immunotherapy target that is expressed at high levels on regulatory T cells. Agonistic...
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Expression patterns of novel immunotherapy targets in intermediate- and high-grade lung neuroendocrine neoplasms
BackgroundAdvancements in immunotherapeutic approaches only had a modest impact on the therapy of lung neuroendocrine neoplasms (LNENs). Our...
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Utility and impact of quantitative pharmacology on dose selection and clinical development of immuno-oncology therapy
Immuno-oncology (IO) therapies have changed the cancer treatment landscape. Immune checkpoint inhibitors (ICIs) have improved overall survival in...
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Peritumoral administration of DRibbles-pulsed antigen-presenting cells enhances the antitumor efficacy of anti-GITR and anti-PD-1 antibodies via an antigen presenting independent mechanism
BackgroundTNF receptor family agonists and checkpoint blockade combination therapies lead to minimal tumor clearance of poorly immunogenic tumors....
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Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes
Aims/hypothesisSlow progressors to type 1 diabetes are individuals positive for multiple pancreatic islet autoantibodies who have remained...
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Platelet-expressed immune checkpoint regulator GITRL in breast cancer
Owing to their key role in several diseases including cancer, activating and inhibitory immune checkpoint molecules are increasingly exploited as...
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Impact of immune checkpoint molecules on FoxP3+ Treg cells and related cytokines in patients with acute and chronic brucellosis
BackgroundThe immunoregulatory functions of regulatory T cells (Tregs) in the development and progression of some chronic infectious diseases are...
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Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways
The discovery and clinical implementation of immune-checkpoint inhibitors (ICIs) targeting CTLA4, PD-1 and PD-L1 has revolutionized the treatment of...
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Regulatory T cell-mediated immunosuppression orchestrated by cancer: towards an immuno-genomic paradigm for precision medicine
Accumulating evidence indicates that aberrant signalling stemming from genetic abnormalities in cancer cells has a fundamental role in their evasion...
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Selective targeting or reprogramming of intra-tumoral Tregs
Regulatory T cells (Tregs) are critical immunosuppressive cells that are frequently present in the tumor microenvironment of solid cancers and enable...
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Multiply restimulated human cord blood-derived Tregs maintain stabilized phenotype and suppressive function and predict their therapeutic effects on autoimmune diabetes
BackgroundRegulatory T cells (Tregs) are involved in the maintenance of immune homeostasis and immune regulation. Clinical trials on the adoptive...
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Intravenous injection of tumor extracellular vesicles suppresses tumor growth by reducing the regulatory T cell phenotype
BackgroundColorectal cancer is a disease of unmet medical need. Although extracellular vesicles (EVs) have been implicated in anti-tumor responses,...
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Evaluation of regulatory T-cells in cancer immunotherapy: therapeutic relevance of immune checkpoint inhibition
The evolution of the complex immune system is equipped to defend against perilous intruders and concurrently negatively regulate the deleterious...
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Evolution of predictive risk factor analysis for chemotherapy-related toxicity
The causes of variation in toxicity to the same treatment regimen among seemingly similar patients remain largely unknown. There was tremendous...
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Characterization of the tumor immune microenvironment in human papillomavirus-positive and -negative head and neck squamous cell carcinomas
Approximately 15% of advanced head and neck squamous cell carcinomas (HNSCC) respond to anti-PD-(L)1 monotherapies. Tumor PD-L1 expression and human...
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Immune checkpoint targeting antibodies hold promise for combinatorial cancer therapeutics
Through improving the immune system's ability to recognize and combat tumor cells as well as its receptivity to changes in the tumor...
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Comprehensive immunohistochemical analysis of immune checkpoint molecules in adult T cell leukemia/lymphoma
Acute or lymphomatous type adult T cell leukemia/lymphoma (ATLL) is an aggressive hematopoietic malignancy with poor prognosis. We previously...
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Tumorinfiltrierende T-Zellen und natürliche Killerzellen im Melanom
Melanoma is a highly immunogenic cancer with an increased infiltration of lymphocytes (TIL). TIL are a very heterogeneous population which consists...
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HERA-GITRL activates T cells and promotes anti-tumor efficacy independent of FcγR-binding functionality
BackgroundGlucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by...
