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Psychiatric adverse events associated with semaglutide, liraglutide and tirzepatide: a pharmacovigilance analysis of individual case safety reports submitted to the EudraVigilance database
BackgroundSemaglutide, liraglutide and tirzepatide are glucagon-like peptide-1 (GLP-1) receptor agonists that are effective for weight reduction....
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Adverse events of clenbuterol among athletes: a systematic review of case reports and case series
Clenbuterol is a potent beta-2 agonist widely misused by professional athletes and bodybuilders. Information on clenbuterol associated adverse events...
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Endoscopic full-thickness resection for upper gastrointestinal tract lesions: a systematic review and meta-analysis
IntroductionEndoscopic full-thickness resection (EFTR) is used to resect difficult superficial mucosal lesions and sub-epithelial lesions (SELs). We...
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Effectiveness and safety of mexiletine versus placebo in patients with myotonia: a systematic review and meta-analysis
BackgroundThe rare nature of dystrophic and non-dystrophic myotonia has limited the available evidence on the efficacy of mexiletine as a potential...
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Cancer immunotherapy–related adverse events: causes and challenges
Despite the success and ongoing promise of monoclonal antibody–targeted immune checkpoint inhibitor immunotherapy of advanced malignancies, in...
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Safety of Chronic Simvastatin Treatment in Patients with Decompensated Cirrhosis: Many Adverse Events but No Liver Injury
BackgroundThe high mortality rate of decompensated cirrhosis underlines the need for new treatments. Experimental models of cirrhosis and its...
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Evaluating the effectiveness and safety of various Tirzepatide dosages in the management of Type 2 diabetes mellitus: a network meta-analysis of randomized controlled trials
PurposeExcess body fat, insulin resistance, and abnormal lipid levels signal type 2 diabetes mellitus (DM2). Globally, 536.6 million people suffer...
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“Side effects--part of the package”: a mixed methods approach to study adverse events among patients being programmatically treated for DR-TB in Gujarat, India
BackgroundHigh rates of Adverse Events (AEs) during treatment is one of the leading causes of unsuccessful treatment outcomes among patients with...
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Dual latent tuberculosis screening with tuberculin skin tests and QuantiFERON-TB assays before TNF-α inhibitor initiation in children in Spain
Tumor-necrosis-factor-α inhibitors (anti-TNF-α) are associated with an increased risk of tuberculosis (TB) disease, primarily due to reactivation of...
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Evaluation of efficacy and safety profile of tadalafil 5 mg daily dose in the tablet form versus oral dispersible film in men with mild-to-moderate erectile dysfunction: a comparative placebo-controlled study
PurposeWe aimed to compare the efficacy, safety, and compliance of tadalafil 5 mg daily dose in the tablet form versus oral dispersible film (ODF) in...
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Association Between Adverse Childhood Experiences and Oral Health in Adulthood: A Systematic Sco** Review
PurposeA gap remains in the synthesis of studies focusing on the long-term effects of Adverse Childhood Experiences (ACEs) on the oral health of...
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Analysis of Surgical Mortalities Using the Fishbone Model for Quality Improvement in Surgical Disciplines
BackgroundThe healthcare industry is complex and prone to the occurrence of preventable patient safety incidents. Most serious patient safety events...
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The cytokeratin 17 expression in primary ovarian tumors has diagnostic but not prognostic significance
We assessed the value of cytokeratin 17 (CK17) expression for the differential diagnosis between primary ovarian mucinous tumors and metastases from...
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Efficacy and gastrointestinal tolerability of methotrexate in late-onset rheumatoid arthritis patients: a prospective cohort study
BackgroundThe proportion of the late-onset forms of disease is growing in rheumatoid arthritis (RA) population. Concerns about comorbidities and drug...
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Study the response of Qurevo (ombitasvir, paritaprevir, and ritonavir) in end-stage renal disease patients with hepatitis C virus
BackgroundOut of the 185 million people infected with hepatitis C virus (HCV) worldwide according to the World Health Organization (WHO), Egypt had...
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Efficacy and safety of intravenous immunoglobulin therapy in systemic sclerosis: a systematic review
Background and objectiveSystemic sclerosis (SSc) is a highly heterogeneous disease whose treatment is based mainly on immunosuppressants,...
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Omentopexy Effect on the Upper Gastrointestinal Symptoms and the Esophagogastroduodenoscopy Findings in Patients Undergoing Sleeve Gastrectomy
BackgroundLaparoscopic sleeve gastrectomy (LSG) has gained acceptance worldwide. However, SG has its own complications that need a specialized...
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Day of Surgery Admission (DOSA): Thirteen Years’ Experience in a Resource-Limited Hospital in East Sudan-Kassala
With the growing need for health services, proper bed capacity management is mandatory to avoid patient rejection or cancellation of a procedure....
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A Comparative View of Reported Adverse Effects of Statins in Social Media, Regulatory Data, Drug Information Databases and Systematic Reviews
IntroductionThere are few studies assessing how data on adverse drug events from consumers on social media compare with other sources.
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Efficacy and safety of gut microbiota-based therapies in autoimmune and rheumatic diseases: a systematic review and meta-analysis of 80 randomized controlled trials
BackgroundPrevious randomized controlled trials (RCTs) suggested that gut microbiota-based therapies may be effective in treating autoimmune...
