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HLF regulates ferroptosis, development and chemoresistance of triple-negative breast cancer by activating tumor cell-macrophage crosstalk
Tumor-associated macrophages (TAMs) are major components of the tumor microenvironment (TME) which are closely associated with the tumor malignant...
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Expanding potential targets of herbal chemicals by node2vec based on herb–drug interactions
BackgroundThe identification of chemical–target interaction is key to pharmaceutical research and development, but the unclear materials basis and...
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Targeted sequencing of DNA/RNA combined with radiomics predicts lymph node metastasis of papillary thyroid carcinoma
ObjectiveThe aim of our study is to find a better way to identify a group of papillary thyroid carcinoma (PTC) with more aggressive behaviors and to...
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Multi-omics Analysis Reveals the Crucial Mediators of DJB in the Treatment of Type 2 Diabetes
PurposeDuodenal-jejunal bypass (DJB) has a definite hypoglycemic effect; however, the intrinsic mechanisms remain unclear. The purpose of this study...
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A mutation in the ZNF687 gene that is responsible for the severe form of Paget’s disease of bone causes severely altered bone remodeling and promotes hepatocellular carcinoma onset in a knock-in mouse model
Paget’s disease (PDB) is a late-onset bone remodeling disorder with a broad spectrum of symptoms and complications. One of the most aggressive forms...
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Body mass index and γ-glutamyl transferase expression in normal and cancerous breast tissue
BackgroundLocalized to cell membrane, γ-glutamyl transferase (GGT) is a reliable marker for the evaluation of cell distress occurring in several...
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GGT5: a potential immunotherapy response inhibitor in gastric cancer by modulating GSH metabolism and sustaining memory CD8+ T cell infiltration
PurposeThe variable responses to immunotherapy observed in gastric cancer (GC) patients can be attributed to the intricate nature of the tumor...
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Metabolic alterations in hereditary and sporadic renal cell carcinoma
Kidney cancer is the seventh leading cause of cancer in the world, and its incidence is on the rise. Renal cell carcinoma (RCC) is the most common...
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Involvement of Kindlin-1 in cutaneous squamous cell carcinoma
Kindler syndrome (KS) is a rare genodermatosis resulting from loss-of-function mutations in FERMT1 , the gene that encodes Kindlin-1. KS patients have...
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Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney
Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-dependent, lipid peroxidation-driven membrane destruction that can...
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Gamma-glutamyl transpeptidase and indirect bilirubin may participate in systemic inflammation of patients with psoriatic arthritis
BackgroundPrevious studies have suggested that systemic metabolic abnormalities are closely related to psoriatic arthritis (PsA). Gamma-glutamyl...
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Serum γ-glutamyltransferase level and incidence risk of metabolic syndrome in community dwelling adults: longitudinal findings over 12 years
PurposeAlthough a recent meta-analysis demonstrated a positive association between serum γ-glutamyltransferase (GGT) and metabolic syndrome (MetS),...
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Uncovering the Cellular Microenvironment in Chronic Rhinosinusitis via Single-Cell RNA Sequencing: Application and Future Directions
Chronic rhinosinusitis (CRS) is a heterogenic disease characterized by persistent mucosal inflammation of the upper airway. Researches of CRS have...
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Bioinformatics approach reveals the critical role of the NOD-like receptor signaling pathway in COVID-19-associated multiple sclerosis syndrome
Multiple sclerosis (MS) is a kind of central nervous system (CNS) autoimmune disease, which mainly damages nerves, the brain, and the spinal cord....
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ɤ-glutamyl hydroxymethyl rhodamine green fluorescence as a prognostic indicator for lung cancer
Objectiveɤ-glutamyltranspeptidase is an enzyme expressed in various malignancies including lung cancer. It rapidly activates non-fluorescent...
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RNA-seq research landscape in Africa: systematic review reveals disparities and opportunities
RNA sequencing has emerged as the standard method for transcriptome profiling of several human diseases. We performed a systematic review detailing...
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Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies
Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal accumulation of iron-dependent membrane-localized lipid...
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Evaluation of dynamic thiol/disulfide homeostasis in hereditary tyrosinemia type 1 patients
BackgroundDespite successful treatment with nitisinone, the pathophysiology of long-term complications, including hepatocellular carcinoma and mental...
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Salidroside protects RGC from pyroptosis in diabetes-induced retinopathy associated with NLRP3, NFEZL2 and NGKB1, revealed by network pharmacology analysis and experimental validation
ObjectiveTo investigate the effect of salidroside (SAL) in protecting retinal ganglion cell (RGC) from pyroptosis and explore associated molecular...
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Differentially expressed transcripts of Tetracapsuloides bryosalmonae (Cnidaria) between carrier and dead-end hosts involved in key biological processes: novel insights from a coupled approach of FACS and RNA sequencing
Tetracapsuloides bryosalmonae is a malacosporean endoparasite that infects a wide range of salmonids and causes proliferative kidney disease (PKD)....
