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Fipronil disturbs the antigen-specific immune responses and GABAergic gene expression in the ovalbumin-immunized BALB/c mice
BackgroundFipronil (FPN) is a broad-spectrum pesticide and commonly known as low toxicity to vertebrates. However, increasing evidence suggests that...
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The role of anterior insula–brainstem projections and alpha-1 noradrenergic receptors for compulsion-like and alcohol-only drinking
Compulsion-like alcohol drinking (CLAD), where consumption continues despite negative consequences, is a major obstacle to treating alcohol use...
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Neuropsychiatric lupus erythematosus with neurogenic pulmonary edema and anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor limbic encephalitis: a case report
BackgroundSystemic lupus erythematosus (SLE) is a chronic multisystem autoimmune inflammatory disease predominantly found in women of child-bearing...
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Nck1 activity in lateral amygdala regulates long-term fear memory formation
Fear conditioning leads to long-term fear memory formation and is a model for studying fear-related psychopathological conditions such as phobias and...
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Repositioning synthetic glucocorticoids in psychiatric disease associated with neural autoantibodies: a narrative review
Synthetic glucocorticoids (sGCs) are a well-investigated and standard drug therapy for disorders associated with CNS inflammation. Less is known...
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Ketamine and Zinc: Treatment of Anorexia Nervosa Via Dual NMDA Receptor Modulation
Anorexia nervosa is a disorder associated with serious adverse health outcomes, for which there is currently considerable treatment ineffectiveness....
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Diagnostik und Therapie klinisch relevanter paraneoplastischer Syndrome
Paraneoplastic syndromes (PS) are rare disorders with often complex clinical manifestations that occur in association with a tumor without being...
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Retrospective analysis of COVID-19 patients with Guillain–Barre, Miller–Fisher, and opsoclonus–myoclonus–ataxia syndromes—a case series
BackgroundIn accordance with the rising number of SARS-CoV‑2 infections, reports of neurological complications have also increased. They include...
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Treatment Approaches in Pediatric Relapsing Autoimmune Encephalitis
Purpose of reviewAutoimmune encephalitis (AE) is increasingly recognized as a treatable cause of encephalitis in children. While prior observational...
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Prognostic and relapsing factors of primary autoimmune cerebellar ataxia: a prospective cohort study
ObjectiveThe objective of this study was to investigate the factors influencing relapse and prognosis in patients with primary autoimmune cerebellar...
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Caspr2 antibodies in herpes simplex encephalitis: an extension of the spectrum of virus induced autoimmunity? – A case report
BackgroundPost herpes simplex virus (HSV) autoimmune encephalitis has been reported mainly in association with NMDA receptor antibodies, however,...
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Mycophenolate mofetil reduces the risk of relapse in anti-leucine-rich glioma–inactivated protein 1 encephalitis: a prospective observational cohort study
BackgroundMycophenolate mofetil (MMF) is frequently used in the treatment of neurological autoimmune disorders. However, its effect on the relapse...
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Genetic exploration of Dravet syndrome: two case report
BackgroundDravet syndrome is an infantile-onset developmental and epileptic encephalopathy (DEE) characterized by drug resistance, intractable...
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Encephalitis-like episodes with cortical edema and enhancement in patients with neuronal intranuclear inclusion disease
ObjectivesNeuronal intranuclear inclusion disease (NIID) exhibited significant clinical heterogeneities. However, the clinical features, radiographic...
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Repeated methamphetamine administration produces cognitive deficits through augmentation of GABAergic synaptic transmission in the prefrontal cortex
Methamphetamine (METH) abuse is associated with the emergence of cognitive deficits and hypofrontality, a pathophysiological marker of many...
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Anti-Tr/DNER antibody–associated cerebellar ataxia: three rare cases report and literature review
BackgroundTo report three cases of autoimmune cerebellar ataxia related to anti-delta/notch-like epidermal growth factor-related receptor (Tr/DNER)...
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Toscana virus encephalitis in Southwest Germany: a retrospective study
BackgroundToscana virus (TOSV) is an arthropod-borne virus transmitted by phlebotomine sandflies ( Phlebotomus sp.) widespread throughout the...
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Autoimmune encephalitis: an observational study from South India
BackgroundEver since AE was acknowledged as a potentially treatable cause of encephalitis, it has been increasingly recognised worldwide. Data...
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Ketamine’s mechanism of action with an emphasis on neuroimmune regulation: can the complement system complement ketamine’s antidepressant effects?
Over 300 million people worldwide suffer from major depressive disorder (MDD). Unfortunately, only 30–40% of patients with MDD achieve complete...
