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Distributive randomization: a pragmatic fractional factorial design to screen or evaluate multiple simultaneous interventions in a clinical trial
BackgroundIn some medical indications, numerous interventions have a weak presumption of efficacy, but a good track record or presumption of safety....
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Protocol for an evaluation of adherence monitoring and support interventions among people initiating antiretroviral therapy in Cape Town, South Africa—a multiphase optimization strategy (MOST) approach using a fractional factorial design
BackgroundSouth Africa bears a large HIV burden with 7.8 million people with HIV (PWH). However, due to suboptimal antiretroviral therapy (ART)...
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A randomised fractional factorial screening experiment to predict effective features of audit and feedback
BackgroundAudit and feedback aims to improve patient care by comparing healthcare performance against explicit standards. It is used to monitor and...
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Using the multiphase optimization strategy to adapt cognitive processing therapy (CPT MOST): study protocol for a randomized controlled factorial experiment
BackgroundApproximately ten percent of US military veterans suffer from posttraumatic stress disorder (PTSD). Cognitive processing therapy (CPT) is a...
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Experimental design approach, screening and optimization of system variables, analytical method development of flurbiprofen in nanoparticles and stability-indicating methods for high-pressure liquid chromatography
BackgroundThe development of chromatographic method and the validation of a sensitive, simple, efficient, and reversed-phase high-performance liquid...
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Multiphase optimization of a multicomponent intervention for informal dementia caregivers: a study protocol
BackgroundFamily caregiver interventions are essential to support dementia caregiving. However, such interventions are typically complex and consist...
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Development of a multicomponent implementation strategy to reduce upper gastrointestinal bleeding risk in patients using warfarin and antiplatelet therapy, and protocol for a pragmatic multilevel randomized factorial pilot implementation trial
BackgroundThe concomitant use of anticoagulant and antiplatelet medications increases the risk of upper gastrointestinal (GI) bleeding. Two underused...
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Empirical Development of a Behavioral Intervention for African American/Black and Latino Persons with Unsuppressed HIV Viral Load Levels: An Application of the Multiphase Optimization Strategy (MOST) Using Cost-Effectiveness as an Optimization Objective
We used results from an optimization randomized controlled trial which tested five behavioral intervention components to support HIV antiretroviral...
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Review of Laser Treatments for Post-Inflammatory Hyperpigmentation in Skin of Color
Post-inflammatory hyperpigmentation is an extremely common disorder of pigmentation in skin of color. It most frequently and severely affects...
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The application of discrete choice experiments eliciting young peoples’ preferences for healthcare: a systematic literature review
ObjectivesUnderstanding young people’s preferences for healthcare is critical for reducing the negative effect of undesirable choices. This review...
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Supporting adjuvant endocrine therapy adherence in women with breast cancer: the development of a complex behavioural intervention using Intervention Map** guided by the Multiphase Optimisation Strategy
BackgroundAdjuvant endocrine therapy (AET) reduces the risk of breast cancer recurrence and mortality. However, up to three-quarters of women with...
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Stated patient preferences for overnight at-home diagnostic assessment of sleep disorders
PurposeThe diagnostic workup for assessment of sleep disorders commonly involves overnight testing to assess sleep patterns and pathological events....
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Preparation and characterization of polymyxin B- and histidine-coupled magnetic nanoparticles for purification of biologics from acquired endotoxin contamination
BackgroundEndotoxin is a major process-related impurity that can act as a strong immunostimulant leading to fever and hypotensive shock. Thus, the US...
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Factors influencing UK residents’ preferences in how psychologists present themselves online: a conjoint analysis during the early months of the COVID-19 pandemic
BackgroundThe COVID-19 pandemic has led to a surge in mental health issues in the UK and worldwide, yet many UK residents have not received the help...
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The elicitation of patient and physician preferences for calculating consumer-based composite measures on hospital report cards: results of two discrete choice experiments
PurposeThe calculation of aggregated composite measures is a widely used strategy to reduce the amount of data on hospital report cards. Therefore,...
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How can the utilisation of help for mental disorders be improved? A quasi-experimental online study on the changeability of stigmatising attitudes and intermediate variables in the process of utilisation
BackgroundEpidemiological studies show that even in highly developed countries many people with depression do not seek help for their mental health...
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The Opportunity – VAWA 2013 Reauthorization Provides a Natural Experiment for Bystander Efficacy Evaluation
This methods paper describes the fractional factorial design within the context of an evaluation of campus bystander programming. Prior evaluations...
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Discrete Choice Experiments in Health State Valuation: A Systematic Review of Progress and New Trends
BackgroundDiscrete choice experiments (DCEs) are increasingly used in health state valuation studies.
ObjectiveThis systematic review updates the...
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Multivariate optimization and evaluation of quaternary mixture in bulk and co-formulated dosage forms by central composite design
BackgroundThe current study describes the use of central composite design for multivariate optimization of resolution and retention time, taking into...
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Comparing Preferences for Disease Profiles: A Discrete Choice Experiment from a US Societal Perspective
ObjectivesThere is increasing interest in expanding the elements of value to be considered when making health policy decisions. To help inform value...
