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Expression and significance of Fractalkine/CX3CL1 in MPO-AAV-associated glomerulonephritis rats
ObjectiveTo investigate the expression and significance of Fractalkine (CX3CL1, FKN) in serum and renal tissue of myeloperoxidase and anti-neutrophil...
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Anti-CX3CL1 (fractalkine) monoclonal antibody attenuates lung and skin fibrosis in sclerodermatous graft-versus-host disease mouse model
BackgroundSystemic sclerosis (SSc) is an autoimmune disease characterized by vascular injury and inflammation, followed by excessive fibrosis of the...
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Fractalkine deficiency attenuates LPS-induced acute kidney injury and podocyte apoptosis by targeting the PI3K/Akt signal pathway
BackgroundPodocyte injury is a major biomarker of primary glomerular disease, which leads to massive proteinuria and kidney failure. The increased...
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Implications of fractalkine on glial function, ablation and glial proteins/receptors/markers—understanding its therapeutic usefulness in neurological settings: a narrative review
BackgroundFractalkine (CX3CL1) is a chemokine predominantly released by neurons. As a signaling molecule, CX3CL1 facilitates talk between neurons and...
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The potential association between a new angiogenic marker fractalkine and a placental vascularization in preeclampsia
PurposeImpaired angiogenesis is one of the most common findings in preeclamptic placentas. A new angiogenetic role of fractalkine (CX3CL1) is...
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Altered expression of cytokines, chemokines, growth factors, and soluble receptors in patients with colorectal cancer, and correlation with treatment outcome
Insofar as they play an important role in the pathogenesis of colorectal cancer (CRC), this study analyzes the serum profile of cytokines,...
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Overexpression of fractalkine and its histopathological characteristics in primary pterygium
PurposeThis study aimed to evaluate the differences in the expressions of fractalkine in normal bulbar conjunctiva and primary pterygium tissues.
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Glucocorticoid use in acute respiratory failure from pulmonary causes and association with early changes in the systemic host immune response
BackgroundGlucocorticoids are commonly used in patients with or at-risk for acute respiratory distress syndrome (ARDS), but optimal use remains...
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Use of novel structural features to identify urinary biomarkers during acute kidney injury that predict progression to chronic kidney disease
BackgroundA significant barrier to biomarker development in the field of acute kidney injury (AKI) is the use of kidney function to identify...
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Photobiomodulation-induced analgesia in experimental temporomandibular disorder involves central inhibition of fractalkine
Temporomandibular disorder (TMD) is a collective term that encompasses a set of clinical problems that affect the masticatory muscles, the...
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Alterations of the expression levels of glucose, inflammation, and iron metabolism related miRNAs and their target genes in the hypothalamus of STZ-induced rat diabetes model
BackgroundThe hypothalamus of the central nervous system is implicated in the development of diabetes due to its glucose-sensing function....
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Fractalkine: an inflammatory chemokine elevated in subjects with polycystic ovary syndrome
PurposeFractalkine (FKN) is an inflammatory chemokine related to reproductive system and glucose metabolism. There is a link between FKN and...
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Serum biomarkers of neuroinflammation and blood-brain barrier leakage in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is an incurable and rapidly progressive neurological disorder. Biomarkers are critical to understanding disease...
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Occurrence of new or more severe headaches following COVID-19 is associated with markers of microglial activation and peripheral sensitization: results from a prospective cohort study
BackgroundNew onset or worsening of a headache disorder substantially contributes to the disease burden of post-COVID-19. Its management poses a...
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The role of microglia in the development of diabetic retinopathy
Diabetic retinopathy is a vision-threatening disease and remains the most feared complication for those living with diabetes. Historically, the...
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FKN/CX3CR1 axis facilitates migraine-Like behaviour by activating thalamic-cortical network microglia in status epilepticus model rats
BackgroundThe incidence of migraines is higher among individuals with epilepsy than in healthy individuals, and these two diseases are thought to...
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Evaluation of cytokines in the tumor microenvironment of lung cancer using bronchoalveolar lavage fluid analysis
IntroductionLung cancer is the leading cause of death by cancer. In recent years, immunotherapy with checkpoint inhibitors (ICI) emerged as a...
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Microglial contribution to the pathology of neurodevelopmental disorders in humans
Microglia are the brain’s resident macrophages, which guide various developmental processes crucial for brain maturation, activity, and plasticity....
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Plasma protein biomarkers reflective of the host response in patients develo** Intensive Care Unit-acquired pneumonia
BackgroundImmune suppression has been implicated in the occurrence of pneumonia in critically ill patients. We tested the hypothesis that Intensive...
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Altered serum level of metabolic and endothelial factors in patients with systemic sclerosis
Systemic sclerosis (SSc) is a chronic connective tissue disease characterized by progressive fibrosis, vascular impairment and immune abnormalities....
